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Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl

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Abstract

The petroleum ether extract of Viola websteri Hemsl. (Violaceae) was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. The main antiplasmodial principles, 6-(8′Z-pentadecenyl)-salicylic acid (1) and 6-(8′Z, 11′Z, 14′Z-heptadecatrienyl)-salicylic acid (2), have been isolated from V. websteri for the first time. This is the first report on the antiplasmodial activity of the compounds from V. websteri.

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Acknowledgment

This work was supported by the MRC program of MOST/KOSEF (grant #: R13-2005-013-01000-0), Korea.

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Authors and Affiliations

  1. Department of Integrative Medicine, College of Medicine, Korea University, Anam-dong 5ga, Seongbuk-gu, Seoul, 136-705, South Korea

    Sung Jae Lee

  2. Department of Diagnostics, Cardiovascular Medical Research Center, College of Korean Medicine, Dongguk University, Gyeongju, 780-714, South Korea

    Won-Hwan Park

  3. Cardiovascular Medical Research Center, Dongguk University, Gyeongju, 780-714, South Korea

    Hyung-In Moon

  4. Inam Neuro Science Research Center, Department of Neurology, Wonkwang University Sanbon Medical Center, Sanbon-dong, Gunpo, Kyunggido, 435-040, South Korea

    Hyung-In Moon

Authors
  1. Sung Jae Lee
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  2. Won-Hwan Park
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  3. Hyung-In Moon
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Corresponding author

Correspondence to Hyung-In Moon.

Additional information

Won-Hwan Park and Hyung-In Moon equally contributed to this work.

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Lee, S.J., Park, WH. & Moon, HI. Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl. Parasitol Res 104, 463–466 (2009). https://doi.org/10.1007/s00436-008-1205-z

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  • DOI: https://doi.org/10.1007/s00436-008-1205-z

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