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The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan

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Abstract

In this study, antibodies (Ab) directed against three MSP antigens; MSP119, MSP2A, and MSP2B were analyzed in blood samples obtained from 223 Sudanese patients who presented with either severe malaria (SM) or uncomplicated malaria (UM) and from 117 malaria-free donors (MF). The results showed that the prevalence of MSP Abs was associated with the clinical outcome of malaria infection, and the Ab prevalence was age-dependent (P < 0.0005). More importantly, the prevalence of MSP Abs against the test antigens was lower in SM compared to UM (P = 0.001 to 0.020), suggesting a protective role for these Abs against SM. Furthermore, the Ab responses between individual complications of SM were significantly different.

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Acknowledgement

We are thankful to the patients and their guardians and to the volunteers for the cooperation and willingness to participate in this study. Jana McBride, David Cavanagh, and Gamila Ibrahim are thanked for provision of the MSP antigens. Our sincere gratitude is extended to Dr. John Horton, for his big effort in editing and correcting this manuscript. This investigation received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) and the Multilateral Initiative on Malaria in Africa (MIM), project ID A00003.

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Authors and Affiliations

  1. Malaria Research Centre (MalRC), Department of Biochemistry and Department of Microbiology and Immunology, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan

    Thoraya M E A-Elgadir, Mustafa I. Elbashir, Ishraga E A-Elbasit, Gehad ElGhazali & Hayder A. Giha

  2. Department of Immunology, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

    Klavs Berzins

  3. Department of Biochemistry and Department of Family and Community Medicine, Faculty of Medicine and Medical Sciences, Arabian Gulf University (AGU), Manama, Kingdom of Bahrain

    Emad M. Masuadi & Hayder A. Giha

  4. Faculty of Medicine, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia

    Gehad ElGhazali

  5. Department of Biochemistry, Faculty of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 26671, Manama, Kingdom of Bahrain

    Hayder A. Giha

Authors
  1. Thoraya M E A-Elgadir
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  2. Mustafa I. Elbashir
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  3. Klavs Berzins
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  4. Emad M. Masuadi
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  5. Ishraga E A-Elbasit
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  6. Gehad ElGhazali
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  7. Hayder A. Giha
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Corresponding author

Correspondence to Hayder A. Giha.

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A-Elgadir, T.M.E., Elbashir, M.I., Berzins, K. et al. The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan. Parasitol Res 102, 401–409 (2008). https://doi.org/10.1007/s00436-007-0777-3

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  • DOI: https://doi.org/10.1007/s00436-007-0777-3

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