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Effect of metronidazole analogues on Giardia lamblia cultures

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Abstract

We comparatively evaluate the effect of metronidazole (MTZ) and its five analogues on trophozoites of Giardia lamblia axenically growing. The compounds MTZ-Ms, MTZ-I, MTZ-Br, MTZ-N3, and MTZ-NH3Cl were obtained by molecular modification of the side chain of MTZ. Four of them presented higher giardicidal activity when compared with MTZ. Among them, MTZ-Br and MTZ-I were the most active, without cytotoxic effects against mitogen-activated human peripheral blood mononuclear cells (PBMC). The alteration of MTZ side chain constitutes a fruitful field to develop new drugs for the treatment not only of giardiasis but also of other diseases and signalize that metronidazole analogues are promising candidates as giardicidal and should be further evaluated.

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Authors and Affiliations

  1. Departamento de Parasitologia, ICB-UFMG, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil

    Haendel G. N. O. Busatti, Andrea E. D. Vieira, João C. Viana & Maria A. Gomes

  2. Dept. Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte, MG, Brazil

    Hugo E. Silva & Ricardo J. Alves

  3. Fisiologia e Biofísica, Instituto de Ciências Biológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte, MG, Brazil

    Elaine M. Souza-Fagundes

  4. Laboratório de Doença de Chagas, Instituto René Rachou, Fiocruz. Av. Augusto de Lima, 1715, Belo Horizonte, MG, Brazil

    Olindo A. Martins-Filho

Authors
  1. Haendel G. N. O. Busatti
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  2. Andrea E. D. Vieira
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  3. João C. Viana
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  4. Hugo E. Silva
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  5. Elaine M. Souza-Fagundes
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  6. Olindo A. Martins-Filho
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  7. Ricardo J. Alves
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  8. Maria A. Gomes
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Corresponding author

Correspondence to Maria A. Gomes.

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Busatti, H.G.N.O., Vieira, A.E.D., Viana, J.C. et al. Effect of metronidazole analogues on Giardia lamblia cultures. Parasitol Res 102, 145–149 (2007). https://doi.org/10.1007/s00436-007-0723-4

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  • DOI: https://doi.org/10.1007/s00436-007-0723-4

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