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Activity of 8.O.4′-neolignans against Trypanosoma cruzi

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Abstract

The in vitro evaluation of a series of 8.O.4′-neolignans (in their ketone, alcohol, and acetylated forms) on the proliferation of Trypanosoma cruzi led to the detection of three compounds with interesting activities against T. cruzi epimastigotes. These compounds also inhibited the in vitro differentiation of epimastigotes to trypomastigotes. When tested against HeLa cells, the same compounds did not affect the cell vitality and showed a low influence on cell viability as measured by dimethylthiazol diphenyltetrazolium bromide reduction. The three phenylpropanoid moieties tested did not show any activity against T. cruzi. One of the tested compounds, compound 4 (3,4-methylenedioxi7-oxo-1′-allyl-3′,5′-dimethoxy-8.O.4′-neolignan) showed the best performance in both trypanocide and cytotoxic assays, suggesting that it should be considered as a leading structure for further research.

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Aknowledgments

E.S. is a carrier member of the National Research Council (CONICET), Argentina. This work was founded by ANPCyT (PICT R 260 and PICT R 300). E.S. and S.A.Z acknowledge UNR and RIBIOFAR (CYTED).

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Authors and Affiliations

  1. Area Parasitología,Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina

    Isabel Nocito & Esteban Serra

  2. Area Farmacognosia,Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina

    María Victoria Castelli & Susana A. Zacchino

  3. Instituto de Biología Molecular y Celular de Rosario,Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina

    Esteban Serra

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  1. Isabel Nocito
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  2. María Victoria Castelli
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  3. Susana A. Zacchino
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  4. Esteban Serra
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Correspondence to Esteban Serra.

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Nocito, I., Castelli, M.V., Zacchino, S.A. et al. Activity of 8.O.4′-neolignans against Trypanosoma cruzi . Parasitol Res 101, 1453–1457 (2007). https://doi.org/10.1007/s00436-007-0657-x

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  • DOI: https://doi.org/10.1007/s00436-007-0657-x

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