Abstract
Subclasses of antibodies to the C-terminal 19 kDa fragment of the Plasmodium vivax merozoite surface protein 1 (PvMSP-119) were assessed among subjects with distinct degrees of malaria exposure in the Brazilian endemic area. The PvMSP-119 specific IgG1and IgG3 levels were low among subjects with long-term exposure (~19 years) when compared to subjects less and sporadically exposed (<1 year). No statistically difference was observed in IgG subclass distribution of antibodies from symptomatic Plasmodium-infected patients, asymptomatic parasite carriers and non-infected subjects living in a same mesoendemic area. Subjects briefly exposed to a P. vivax outbreak living in a rural community outside the endemic area were also evaluated to measure the persistence of specific antibodies. IgG anti-PvMSP-119 antibodies persisted in 40% of the subjects who had had malarial symptoms 8 months before and decreased after 7 years (28%). Specific IgG1 were the predominant isotype. Our study emphasizes the highly immunogenicity of the PvMSP-119 and points toward its possible use as a potential malaria vaccine.
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Acknowledgments
This work was financially supported by Fundação de Amparo à Pesquisa do Estado de Minas Gerais FAPEMIG (grant no. CBB2323/97). Informed consent was obtained from subjects according to the Universidade Federal de Minas Gerais Ethics Committee (15 April 1998) and Fundação Oswaldo Cruz Ethics Committee (26 November 1994).
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Morais, C.G., Soares, I.S., Carvalho, L.H. et al. IgG isotype to C-terminal 19 kDa of Plasmodium vivax merozoite surface protein 1 among subjects with different levels of exposure to malaria in Brazil. Parasitol Res 95, 420–426 (2005). https://doi.org/10.1007/s00436-005-1314-x
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DOI: https://doi.org/10.1007/s00436-005-1314-x