Abstract
Neonatal porcine isosporosis is known to cause serious economic losses in piglet farms by causing severe enteritis with dehydration, weight loss and reduced development in the affected animals, predominantly during the first weeks of life. In the present study, piglets experimentally infected with Isospora suis were treated with Bay Vi 9143, a symmetrical triazintrione, at different days post-infection. As shown by clinical and pathological examinations, Bay Vi 9143 is effective against the asexual and sexual stages of I. suis at all selected treatment times. However, the therapeutic use at an early stage of asexual multiplication is most effective before the onset of clinical symptoms.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Biester HE, Murray C (1934) Studies in infectious enteritis of swine. VIII. Isospora suis n. sp. in swine. J Am Vet Med Assoc 85:207–219
Chae C, Kwon D, Kim O, Min K, Cheon DS, Choi C, Kim B, Suh J (1998) Diarrhoea in nursing piglets associated with coccidiosis: prevalence, microscopic lesions and coexisting microorganisms.Vet Rec 143:417–420
Driesen SJ, Fahy VA, Carland PG (1995) The use of toltrazuril for the prevention of coccidiosis in piglets before weaning. Aust Vet J 72:139–141
Hackstein JHP, Mackenstedt U, Mehlhorn H, Meijerink H, Schubert H, Leunissen JAM (1995) Parasitic apicomplexans harbour a chlorophyll a-D1 complex, the potential target for therapeutic triazines. Parasitol Res 81:207–216
Harder A, Haberkorn A (1989) Possible mode of action of toltrazuril: studies on two Emeria species and mammalian Ascaris suum enzymes. Parasitol Res 76:8–12
Henriksen SA, Christensen JPB (1992) Demonstration of Isospora suis oocysts in faecal samples. Vet Rec 131:443–444
Madsen P, Henriksen SVAA, Larsen K (1994) Prophylactic treatment of Isospora suis coccidiosis in piglets with toltrazuril in a special oral suspension. Proceedings of the International Pig Veterinary Society, 26–30 June, Bangkok, Thailand, p 256
Martineau GP, Menard J, Carabin H, Villeneuve A, Dumas G (1994) Strategic control of porcine coccidiosis with Toltrazuril. Proceedings of the International Pig Veterinary Society, 26–30 June, Bangkok, Thailand, p 243
Matuschka FR (1982) Ultrastructural evidence of endodyogeny by Isospora suis in pigs. Z Parasitenkd 67:27–30
Matuschka FR, Heydorn AO (1980) Die Entwicklung von Isospora suis Biester und Murray 1934 (Sporozoa: Coccidia: Eimeriidae) im Schwein. Zool Beitr NF 26:405–476
Mehlhorn H, Ortmann-Falkenstein G, Haberkorn A (1984) The effects of sym. Triazinones on developmental stages of Eimeria tenella, E. maxima and E. acervulina: a light and electron microscopical study. Z Parasitenkd 70:173–182
Mundt HC (2000) Baycox 5% an anticoccidial for the treatment of Isospora suis coccidiosis in piglets.Proceedings of the 16th International Pig Veterinary Society Congress, Melbourne, Australia, p 80
Mundt HC, Koudela B (2001) Don't forget coccidiosis. Pig Prog 17:2–4
Stuart BP, Lindsay DS, Ernst JV, Gosser HS (1980) Isospora suis enteritis in piglets. Vet Pathol 17:84–93
Varga I (1989) The timing of the treatment of chickens with toltrazuril against coccidiosis. Proceedings of the 13th World Association for the Advancement of Veterinary Parasitology Conference, 7–11 August, Berlin, Germany, S6-5
Acknowledgements
The authors wish to thank Petra Hartmann, Alfred Leufgen and Meike Petersen for excellent technical assistance.The animal experiments mentioned in this paper comply with current German laws.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bach, U., Kalthoff, V., Mundt, HC. et al. Parasitological and morphological findings in porcine isosporosis after treatment with symmetrical triazintriones. Parasitol Res 91, 27–33 (2003). https://doi.org/10.1007/s00436-003-0828-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00436-003-0828-3