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Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin

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Research in Experimental Medicine

Abstract

A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hes-peridin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.

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Abbreviations

DMBA:

7,12-dimethylbenz[a]anthracene

TPA:

12-O-tetra-decanoyl-13-phorbol acetate

FOR:

free oxygen radicals

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Authors and Affiliations

  1. Department of Haematology, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey

    Bülent Berkarda

  2. Oncology Institute, Istanbul University, Istanbul, Turkey

    Hülya Koyuncu

  3. Department of Surgery, Taksim State Hospital, Istanbul, Turkey

    Gürsel Soybir

  4. Department of Biomedical Engineering, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey

    Fikret Baykut

Authors
  1. Bülent Berkarda
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  2. Hülya Koyuncu
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  3. Gürsel Soybir
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  4. Fikret Baykut
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Corresponding author

Correspondence to Gürsel Soybir.

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Berkarda, B., Koyuncu, H., Soybir, G. et al. Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin. Res. Exp. Med. 198, 93–99 (1998). https://doi.org/10.1007/s004330050093

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  • DOI: https://doi.org/10.1007/s004330050093

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