Abstract
Background
Previous researches have indicated physical activity (PA) may be associated with lower risk of lung cancer. However, causal relationship between PA and risk of lung cancer is not clear. We aimed to inspect the causal effect of PA on lung cancer.
Methods
We analyzed summary data of accelerator-measured PA and lung cancer from the genome-wide association study (GWAS) using two‐sample Mendelian randomization (MR) method. We obtained summary data of accelerator-measured PA from UK Biobank, data of lung cancer patients from Consortium and International Lung Cancer Consortium (ILCCO) to investigate possible causal effect of PA on lung cancer.
Results
According to result of MR using inverse variance weighted method (IVW), we found that genetically predicted higher PA level did not causally decrease risk of lung cancer (OR 0.95, 95% CI 0.88–1.03, p = 0.238). Results of MR-Egger and weighted median method were consistent with IVW method.
Conclusion
Our mendelian randomization study showed that genetically higher PA is not causally associated with risk of lung cancer. More researches are needed to investigate relationship between PA and lung cancer.
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Data availability statement
The data that support the findings of this study are openly available in [UK Biobank] at https://doi.org/10.1038/s41366-018-0120-3, [ILCCO] at https://doi.org/10.1038/ng.3002, reference number [9,10].
Abbreviations
- PA:
-
Physical activity
- MR:
-
Mendelian randomization
- SNP:
-
Single-nucleotide polymorphisms
- CI:
-
Confidence interval
- GWAS:
-
Genome-wide association study
- IVW:
-
Inverse variance weighted
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Funding
This work was supported by the National Key R&D Program of China (2016YFC0905500, 2016YFC0905503), the Science and Technology Program of Guangdong (2017B020227001) and the Science and Technology Program of Guangzhou (201704020072). The funders had no role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication.
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WX, JYS, HQZ and LZ designed the study. WX, JYS analysed the data and interpreted the results with the help of JQL, YXZ and ZHZ. WX and JYS drafted the paper. TZ, SDH, YPY, WFF, HYZ and YH critically revised the paper. All authors read and approved the final manuscript.
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Patient consent and ethical approval were waived in our research because they were obtained from the previous original studies.
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The R code for analysis is not publicly available, but is available from corresponding author if required.
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Xian, W., Shen, J., Zhou, H. et al. Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer. J Cancer Res Clin Oncol 147, 177–181 (2021). https://doi.org/10.1007/s00432-020-03409-1
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DOI: https://doi.org/10.1007/s00432-020-03409-1