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Safety and efficacy of CT-guided radioactive iodine-125 seed implantation assisted by a 3D printing template for the treatment of thoracic malignancies

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Objective

To ascertain the safety and efficacy of radioactive iodine-125 seed implantation (RISI) for the treatment of thoracic tumors.

Methods

Clinical patients with primary or metastatic tumors in the chest treated with RISI were analyzed. The RISI process included the following stages: preoperative planning, template design and 3D printing, CT-guided RISI assisted by a template, and postoperative dosimetric verification. The prescribed dose was ≥ 80 Gy. The main analytic measures were the local control (LC) rate and toxicity.

Results

From April 2015 to July 2018, a total of 92 patients, including 41 with lung cancer and 51 with lung metastases, were analyzed. The median lesion diameter was 5 cm. The median postoperative D90 was 142.6 Gy. The median follow-up was 10.7 months. The overall survival rates at 1 year and 3 years were 59.7% and 22.2%, respectively. The LC rates at 1 year and 3 years were 64.9% and 32.8%, respectively. The LC rates at 3 years for patients with D90 < 140 Gy and D90 > 140 Gy were 23.1% and 54.3%, respectively (P = 0.014). The LC rate of metastatic lung cancer was more favorable than that of primary lung cancer. The multivariate analyses showed that the dose and lesion type were independent factors for LC (P < 0.05). No factors were related to OS. The incidence of pneumothorax and hemoptysis was 35.8% and 3.2%, respectively. Few cases of radiotherapy-related toxicity effects were observed.

Conclusions

RISI may be safe and efficacious and is associated with few complications during the treatment of thoracic tumors. If patients need local treatment and surgery or radiotherapy is not available, RISI could be considered.

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Authors and Affiliations

  1. Department of Radiation Oncology, Peking University Third Hospital, No. 49 North Garden Road, Beijing, 100191, People’s Republic of China

    Zhe Ji, Yuliang Jiang, Fuxin Guo, Ran Peng, Haitao Sun, Jinghong Fan, Fei Xu & Junjie Wang

Authors
  1. Zhe Ji
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  2. Yuliang Jiang
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  3. Fuxin Guo
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  4. Ran Peng
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  5. Haitao Sun
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  6. Jinghong Fan
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  7. Fei Xu
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  8. Junjie Wang
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Correspondence to Junjie Wang.

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None of the authors have any conflicts of interest.

Ethical approval

All procedures performed in study involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This retrospective study was approved by the Peking University Third Hospital Medical Science Research Ethics Committee and registered in the Chinese Clinical Trial Registry (ChiCTR) (http://www.chictr.org.cn) with the registration number ChiCTR1800019945.

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Informed consent was obtained from all individual participants included in the study.

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Cite this article

Ji, Z., Jiang, Y., Guo, F. et al. Safety and efficacy of CT-guided radioactive iodine-125 seed implantation assisted by a 3D printing template for the treatment of thoracic malignancies. J Cancer Res Clin Oncol 146, 229–236 (2020). https://doi.org/10.1007/s00432-019-03050-7

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  • DOI: https://doi.org/10.1007/s00432-019-03050-7

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