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Microbiota in cancer development and treatment

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Human microbiota comprises of a variety of organisms ranging from bacterial species to viruses, fungi, and protozoa which are present on the epidermal and mucosal barriers of the body. It plays a key role in health and survival of the host by regulation of the systemic functions. Its apparent functions in modulation of the host immune system, inducing carcinogenesis and regulation of the response to the cancer therapy through a variety of mechanisms such as bacterial dysbiosis, production of genotoxins, pathobionts, and disruption of the host metabolism are increasingly becoming evident.

Methods

Different electronic databases such as PubMed, Google Scholar, and Web of Science were searched for relevant literature which has been reviewed in this article.

Results

Characterization of the microbiome particularly gut microbiota, understanding of the host–microbiota interactions, and its potential for therapeutic exploitation are necessary for the development of novel anticancer therapeutic strategies with better efficacy and lowered off-target side effects.

Conclusion

In this review, the role of microbiota is explained in carcinogenesis, mechanisms of microbiota-mediated carcinogenesis, and role of gut microbiota in modulation of cancer therapy.

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Authors and Affiliations

  1. Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan

    Muhammad Hassan Raza, Kamni Gul, Naveeda Riaz, Maqbool Ur Rehman, Muhammad Abdullah & Muhammad Arshad

  2. Department of Biology, PMAS-Arid Agriculture University, Rawalpindi, Pakistan

    Abida Arshad

  3. Department of Pathology and Blood Bank, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan

    Usman Waheed

  4. Department of Zoology, Azad Jammu and Kashmir University, Muzaffarabad, Pakistan

    Abdul Rauf

  5. Department of Clinical Laboratory Medicine, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia

    Fahad Aldakheel

  6. Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Shatha Alduraywish

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  1. Muhammad Hassan Raza
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  2. Kamni Gul
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  3. Abida Arshad
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  4. Naveeda Riaz
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  6. Abdul Rauf
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  9. Maqbool Ur Rehman
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  10. Muhammad Abdullah
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  11. Muhammad Arshad
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Correspondence to Muhammad Arshad.

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Raza, M.H., Gul, K., Arshad, A. et al. Microbiota in cancer development and treatment. J Cancer Res Clin Oncol 145, 49–63 (2019). https://doi.org/10.1007/s00432-018-2816-0

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