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Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

The objective of this study was to examine patterns of care and survival in a population-based sample of patients with parotid cancer who were treated in Thuringia, a federal state in Germany, between 1996 and 2011.

Methods

Data of 295 patients with primary parotid cancer from the Thuringian cancer registry were evaluated for patient’s characteristics, tumor stage, incidence, and trends in treatment, cancer-specific survival (CSS), and overall survival (OS).

Results

Stages IV tumors and the amount of tumors in all age cohorts ≥45 years of age increased significantly during the observation period (p = 0.002; age all p < 0.05, respectively). The highest increase in crude incidence was observed for salivary duct carcinomas [relative risk per decade (RR) 5.46; 95 % confidence interval (CI) 1.14–26.14] and rare carcinoma subtypes (RR 9.99; 95 % CI 1.85–53.94). CSS at 5 years and at 10 years for all patients was 82.4 and 82.4 %, respectively. OS at 5 years and at 10 years for all patients was 60.1 and 48.2 %, respectively. CSS and OS did not improve over the time. Salivary duct carcinoma showed the lowest 5-year OS (35.6 %). Acinic cell carcinoma had the highest OS rate (85.3 %). Multivariate Cox models revealed that higher grading (G3/G4) was a more powerful independent predictor of decreased OS than TNM stage.

Conclusions

CSS and OS did not improve during the study period. Incidence of parotid cancer increased significantly in elderly patients. It seems that grading is next to patient’s age the better predictor of OS than TNM stage.

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Acknowledgments

We thank all departments and outpatient clinics that were involved in the treatment and data collection of the patients. Particularly, we thank the coordinators of the five Thuringian cancer registries for the collaboration: Hubert Göbel (Erfurt), Karin Fernschild (Gera), Matthias Wackes (Suhl), Uwe Funke (Gera), and Ulrike Burger (Jena).

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Jena University Hospital, Lessingstrasse 2, 07740, Jena, Germany

    Orlando Guntinas-Lichius

  2. Department of Radiooncology, Jena University Hospital, Jena, Germany

    Thomas G. Wendt

  3. Department of Otorhinolaryngology, Suedharzkrankenhaus Nordhausen, Nordhausen, Germany

    Jens Buentzel

  4. Department of Otorhinolaryngology, Helios-Klinikum Erfurt, Erfurt, Germany

    Dirk Esser

  5. Department of Otorhinolaryngology, SRH Zentralklinikum Suhl, Suhl, Germany

    Daniel Böger

  6. Department of Otorhinolaryngology, SRH Wald-Klinikum Gera, Gera, Germany

    Andreas H. Mueller

  7. Department of Oromaxillofacial Surgery, Helios-Klinikum Erfurt, Erfurt, Germany

    Jörn-Uwe Piesold

  8. Department of Oromaxillofacial Surgery and Plastic Surgery, Jena University Hospital, Jena, Germany

    Stefan Schultze-Mosgau

  9. Department of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, Jena, Germany

    Peter Schlattmann

  10. University Tumor Center, Jena University Hospital, Jena, Germany

    Harald Schmalenberg

Authors
  1. Orlando Guntinas-Lichius
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  2. Thomas G. Wendt
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  3. Jens Buentzel
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  7. Jörn-Uwe Piesold
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  8. Stefan Schultze-Mosgau
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  9. Peter Schlattmann
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  10. Harald Schmalenberg
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Corresponding author

Correspondence to Orlando Guntinas-Lichius.

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Guntinas-Lichius, O., Wendt, T.G., Buentzel, J. et al. Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany. J Cancer Res Clin Oncol 141, 1679–1688 (2015). https://doi.org/10.1007/s00432-015-1961-y

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  • DOI: https://doi.org/10.1007/s00432-015-1961-y

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