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An emerging understanding of long noncoding RNAs in kidney cancer

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

Long noncoding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis.

Methods

An electronic search of all relevant publications in peer-reviewed journals before April 2014 was performed on PubMed, Google scholar databases. The keywords of long-coding RNAs, lncRNAs, kidney tumor, renal cancers were used for searching.

Results

The lncRNA biology was introduced into cancer biology from contemporary research, and the regulatory mechanisms of lncRNAs was highlighted at transcriptional, post-transcriptional and epigenetic levels. The kidney cancer-associated onco-lncRNAs (e.g., KCQN1OT1, MALAT-1 and HOTAIT) and tumor suppressive lncRNAs (e.g., H19, GAS5 and MEG3) were summarized and their possible regulatory network was depicted in a comprehensive diagram.

Conclusion

LncRNAs are deregulated in various cancers including kidney cancer, demonstrating both oncogenic and tumor suppressive roles, thus suggesting their aberrant expression may be a substantial contributor in cancer development. LncRNAs could serve as potential diagnostics biomarkers and/or therapeutic targets.

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Acknowledgments

This work was supported, in part, by the National Natural Science Foundation of China (81371611, 81171391, 81372743) and the National Basic Research Priorities Program 973 Project (2014CB744504) from the Ministry of Science and Technology of China. We apologize to those whose research we could not cite due to the limitations of our topic and space.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Urology, Jinling Hospital, Nanjing University School of Medicine, No. 305, Zhongshandong Road, Nanjing, 210002, Jiangsu, People’s Republic of China

    Shuigen Zhou & Zhengyu Zhang

  2. Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, Jiangsu, People’s Republic of China

    Jiandong Wang

Authors
  1. Shuigen Zhou
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  2. Jiandong Wang
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  3. Zhengyu Zhang
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Corresponding author

Correspondence to Zhengyu Zhang.

Additional information

Shuigen Zhou and Jiandong Wang have contributed equally to this work.

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Zhou, S., Wang, J. & Zhang, Z. An emerging understanding of long noncoding RNAs in kidney cancer. J Cancer Res Clin Oncol 140, 1989–1995 (2014). https://doi.org/10.1007/s00432-014-1699-y

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  • DOI: https://doi.org/10.1007/s00432-014-1699-y

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