Abstract
Backgrounds
microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics.
Methods
The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software.
Results
In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.
Conclusions
microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.
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Acknowledgments
Our project was supported by grants to Qiu Haifeng from Wuxi medical management center (No. YGM1016). We thank Xia Suhua for the histological assessment and He Jie for revising the manuscript.
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Yu, J., Wang, Y., Dong, R. et al. Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion. J Cancer Res Clin Oncol 138, 671–674 (2012). https://doi.org/10.1007/s00432-012-1147-9
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DOI: https://doi.org/10.1007/s00432-012-1147-9