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Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma

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Abstract

Purpose

The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC.

Methods

We examined the significance of the CD147 and MMP-9 expression in SDC (n = 35), non-cancerous salivary tissue (n = 20) in previously untreated patients using immunohistochemical staining. Furthermore, we analyzed the correlation between the expression of these two genes and various clinicopathologic factors including survival status of patients with SDC.

Results

Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues. The incidences of high expression were 45.71% for CD147 and 51.43% for MMP-9 in 35 SDC tissues, respectively. High expression of CD147 and MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (P CD147 = 0.031; P MMP-9 = 0.020) and overall survival (OS) (P CD147 = 0.044; P MMP-9 = 0.013).

Conclusion

CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China [Grant Number 81170960] and the Ministry of Education College Doctoral Degree Special Fund [Grant Number 20102307110006].

Conflict of interest

All authors declared that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, People’s Republic of China

    Songlin Piao, Fulin Guo & Jie Xue

  2. Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081, Heilongjiang, People’s Republic of China

    Shu Zhao

  3. Department of Medical Pathology, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081, Heilongjiang, People’s Republic of China

    Guodong Yao

  4. Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, People’s Republic of China

    Zhili Wei & Bin Zhang

  5. Center of Morphology, Harbin Medical University, Harbin, 150086, Heilongjiang, People’s Republic of China

    Qi Huang

  6. Hard Tissue Lab, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, People’s Republic of China

    Yao Sun & Bin Zhang

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  1. Songlin Piao
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  2. Shu Zhao
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  3. Fulin Guo
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  7. Qi Huang
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  8. Yao Sun
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  9. Bin Zhang
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Corresponding author

Correspondence to Bin Zhang.

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Songlin Piao and Shu Zhao contributed equally to the work and should be considered co-first authors.

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Piao, S., Zhao, S., Guo, F. et al. Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma. J Cancer Res Clin Oncol 138, 627–635 (2012). https://doi.org/10.1007/s00432-011-1142-6

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  • DOI: https://doi.org/10.1007/s00432-011-1142-6

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