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Thoracic neoplasms at the Jena reference center for soft tissue tumors

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Abstract

Introduction

The Jena Soft Tissue Tumor Reference Center is the major German pathology institute for consultation of malignant mesenchymal tumors. Here, we present the clinicopathological data on thoracic soft tissue tumors of a two-year period.

Methods

The tumors were analyzed according to their localization, type (soft tissue tumor, other tumor type, non-neoplastic lesion) and biological behavior. The frequency of the defined soft tissue tumor entities were considered after categorizing the cases according to the WHO Classification of Tumors. Gender and age were also assessed.

Results

In total, 1,071 cases of thoracic tumors were recorded within the 2 years. The majority were non-epithelial lesions (75.3%, n = 806/1,071), of which 68.1% (n = 549/806) were malignant or intermediate malignant. 107 non-epithelial lesions involved the lung and 37 the pleura. By far the most common lung and pleural tumors were undifferentiated sarcomas. In the lung, other frequent entities were solitary fibrous tumors, synovial sarcomas and leiomyosarcomas. We also recorded 13 non-epithelial tumors of the heart and 66 tumors of the breast with angiosarcomas being the most frequent subtype. There was a female predominance for vascular neoplasms, while men prevailed for adipocytic tumors.

Conclusions

Our study provides information about the frequency, distribution, age and gender of patients with thoracic soft tissue tumors including several rare entities. Thus, it may help in the differential diagnosis of these neoplasms. In addition, we present a model highlighting the potential progression of lung carcinoma to undifferentiated sarcoma via the process of epithelial–mesenchymal transition.

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Abbreviations

JSTTR:

Jena Soft Tissue Tumor Reference Center

WHO:

World Health Organization

STS:

Soft tissue sarcomas

STT:

Soft tissue tumors

PCR:

Polymerase chain reaction

FISH:

Fluorescence in situ hybridization

NOS:

Not otherwise specified

MPNST:

Malignant peripheral nerve sheath tumor

MFH:

Malignant fibrous histiocytoma

ALT:

Atypical lipomatous tumor

SFT:

Solitary fibrous tumor

References

  • Awonuga A, Shavell V et al (2010) Pathogenesis of benign metastasizing leiomyoma: a review. Obstet Gynecol Surv 65(3):189–195

    Article  PubMed  Google Scholar 

  • Baliga M, Flowers R et al (2007) Solitary fibrous tumor of the lung: a case report with a study of the aspiration biopsy, histopathology, immunohistochemistry, and autopsy findings. Diagn Cytopathol 35(4):239–244

    Article  PubMed  Google Scholar 

  • Bertz J, Dahm S et al (2010) Verbreitung von Krebserkrankungen in Deutschland—Entwicklung der Prävalenzen zwischen 1990 und 2010. Robert Koch-Institut, Berlin

    Google Scholar 

  • Dainese E, Pozzi B et al (2010) Primary pleural epithelioid angiosarcoma. A case report and review of the literature. Pathol Res Pract 206(6):415–419

    Article  PubMed  Google Scholar 

  • Fletcher CDM (2007) Diagnostic histopathology of tumors. Elsevier, Boston

    Google Scholar 

  • Fletcher CDM, Krishnan Unni K et al (2002) Pathology and genetics of tumours of soft tissue and bone. IARC Press, Lyon

    Google Scholar 

  • Guo J, Chu X et al (2010) Giant solitary fibrous tumor of the pleura: an analysis of five patients. World J Surg

  • Gutierrez J, Perez E et al (2007) Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry. J Surg Res 141(1):105–114

    Article  PubMed  Google Scholar 

  • Hamilton SR, Aaltonen LA (2000) Pathology and genetics of tumours of the digestive system. IARC Press, Lyon

    Google Scholar 

  • Harms D (2004) Soft tissue malignancies in childhood and adolescence. Pathology and clinical relevance based on data from the kiel pediatric tumor registry. Handchir Mikrochir Plast Chir 36(5):268–274

    Article  PubMed  CAS  Google Scholar 

  • Hill T, Khamis H et al (2005) Comparison of male and female breast cancer incidence trends, tumor characteristics, and survival. Ann Epidemiol 15(10):773–780

    Article  PubMed  Google Scholar 

  • Huang J, Mackillop W (2001) Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer 92(1):172–180

    Article  PubMed  CAS  Google Scholar 

  • Husmann G, Kaatsch P et al (2010) Krebs in Deutschland 2005/2006, Häufigkeiten und trends. Robert Koch-Institut, Berlin

    Google Scholar 

  • Katenkamp D, Katenkamp K (2009) Modern morphological diagnosis and current classification of soft tissue sarcomas. Chirurg 80(3):186–193

    Article  PubMed  CAS  Google Scholar 

  • Kleihues P, Cavanee WK (2000) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon

    Google Scholar 

  • Knösel T, Heretsch S et al (2010) TLE1 is a robust biomarker for synovial sarcoma and correlates with t(X;18): analysis of 319 cases. Eur J Cancer 46(6):1170–1176

    Google Scholar 

  • Kusakabe T, Watanabe K et al (2010) Primary pulmonary synovial sarcoma—transbronchial needle aspiration is a diagnostic approach: a case report with cytological features. Cytopathology 21(1):52–55

    Article  PubMed  CAS  Google Scholar 

  • LeBoit PE, Harms G et al (2006) Pathology and genetics of skin tumours. IARC Press, Lyon

    Google Scholar 

  • Lehnhardt M, Daigeler A et al (2009) Importance of specialized centers in diagnosis and treatment of extremity-soft tissue sarcomas. Review of 603 cases. Chirurg 80(4):341–347

    Article  PubMed  CAS  Google Scholar 

  • Nair N, Basu S (2005) Unsuspected metastatic male breast nodule from synovial sarcoma detected by FDG PET. Clin Nucl Med 30(4):289–290

    Article  PubMed  Google Scholar 

  • Nishiyama A, Yoshioka H et al (2010) Pleural metastases of malignant melanoma. J Thorac Oncol 5(6):908

    Article  PubMed  Google Scholar 

  • Petersen I, Petersen S (2001) Towards a genetic-based classification of human lung cancer. Anal Cell Pathol 22(3):111–121

    PubMed  CAS  Google Scholar 

  • Petersen I, Günther B et al (2011) Update from the soft tissue tumour registry in Jena. Pathologe 32(1):40–46

    Article  PubMed  CAS  Google Scholar 

  • Pinedo-Onofre J, Robles-Pérez E et al (2010) Giant solitary fibrous tumor of the pleura. Cir Cir 78(1):31–43

    PubMed  Google Scholar 

  • Schulze S, Petersen I (2011) Gender and ploidy in cancer survival. Cell Oncol (Dordr) 34(3):199–208

    Google Scholar 

  • Tavassoli FA, Devilee P (2003) Pathology and genetics of tumours of the breast and female genital organs. IARC Press, Lyon

    Google Scholar 

  • Travis WD, Brambilla E et al (2004) Pathology and genetics of tumours of the lung, pleura, thymus and the heart. IARC Press, Lyon

    Google Scholar 

  • Vautravers C, Dewas S et al (2010) Sarcomas in irradiated fields: recent dats. Cancer Radiother 14(1):74–80

    Article  PubMed  CAS  Google Scholar 

  • Weihkopf T, Blettner M et al (2008) Incidence and time trends of soft tissue sarcomas in German children 1985–2004—a report from the population-based German childhood cancer registry. Eur J Cancer 44(3):432–440

    Article  PubMed  Google Scholar 

  • Wiebe T, Wetzer K (1986) Pulmonary and pleural metastases in malignant melanoma. Z Erkr Atmungsorgane 167(1–2):145–151

    PubMed  CAS  Google Scholar 

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Acknowledgments

We would like to thank all colleagues who submit cases to the Jena Soft Tissue Tumor Reference Center. The study was performed in the context of the BMBF project 0315509.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Institute of Pathology, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07740, Jena, Germany

    Kathrin Nitsche, Bianka Günther, Detlef Katenkamp & Iver Petersen

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  1. Kathrin Nitsche
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  2. Bianka Günther
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  3. Detlef Katenkamp
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  4. Iver Petersen
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Correspondence to Iver Petersen.

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Nitsche, K., Günther, B., Katenkamp, D. et al. Thoracic neoplasms at the Jena reference center for soft tissue tumors. J Cancer Res Clin Oncol 138, 415–424 (2012). https://doi.org/10.1007/s00432-011-1108-8

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  • DOI: https://doi.org/10.1007/s00432-011-1108-8

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