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GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis

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Abstract

Purpose

Accumulating evidences implicate the selenium-containing cytosolic glutathione peroxidase, GPx-1, as a determinant of cancer risk and a mediator of the chemopreventive properties of selenium. Since the identification of a well-characterized functional polymorphism named Pro198Leu (rs1050450 C>T) in GPx-1, abundant studies have evaluated the association between Pro198Leu polymorphism and tumor risk in diverse population. But, the available results are conflicting.

Methods

To derive a more precise estimation, we performed a meta-analysis based on 14,372 cases with different tumor types and 18,081 controls from 31 published case–control studies. Published literature from PubMed was retrieved. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.

Results

Overall, the results indicated that individuals who carried variant Leu allele (Pro/Leu and Leu/Leu) were associated with an increased cancer risk [odds ratio (OR) = 1.12, 95% confidence interval (CI) = 1.02–1.23] in a dominant genetic model. In further subgroup analyses, the increased risk of cancer was observed in subgroup of Asians and sample size more than 500 subjects.

Conclusion

These results suggest that the GPx-1 Pro198Leo polymorphism contributes to cancer susceptibility through a disturbed antioxidant balance.

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Acknowledgments

We thank all the people who helped in this study. The work was supported by the Program for Development of Innovative Research Team in the First Affiliated Hospital of Nanjing Medical University, Provincial Initiative Program for Excellency Disciplines, Jiangsu Province and the Natural Science Foundation of Jiangsu Province [BK2008473].

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China

    Jiawei Chen, Qiang Cao, Chao Qin, Pengfei Shao, Yilong Wu & Changjun Yin

  2. Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China

    Meilin Wang & Zhengdong Zhang

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  1. Jiawei Chen
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  2. Qiang Cao
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  3. Chao Qin
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  4. Pengfei Shao
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  5. Yilong Wu
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  6. Meilin Wang
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  8. Changjun Yin
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Correspondence to Changjun Yin.

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J. Chen, Q. Cao and C. Qin contributed equally to this work.

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Chen, J., Cao, Q., Qin, C. et al. GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis. J Cancer Res Clin Oncol 137, 1553–1561 (2011). https://doi.org/10.1007/s00432-011-1033-x

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