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Prognostic role of systemic inflammatory response in renal cell carcinoma: a systematic review and meta-analysis

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Abstract

Purpose

To summarize the global predicting role of systemic inflammatory response for survival in renal cell carcinoma.

Methods

Eligible studies were identified and assessed for quality through multiple search strategies. Data were collected from studies comparing overall, cancer-specific or relapse-free survival in patients with elevated C-reactive protein (CRP), platelet count (PC) and erythrocyte sedimentation rate (ESR) levels with those with lower levels. Studies were pooled, and combined hazard ratios (HRs) of CRP, PC and ESR for survival were calculated, respectively.

Results

A total of 47 studies were included for meta-analysis (18 for CRP, 15 for PC and 14 for ESR). For overall survival, the pooled HR of CRP (3.23, 95% CI: 1.77, 5.89) was higher than that of PC (1.96, 95% CI: 1.40, 2.75) and that of ESR (1.86, 95% CI: 1.34, 2.59). These indicators were strong predictors for cancer-specific survival with individual HRs being 3.46 (95% CI, 2.80, 4.27) of CRP, 3.22 (95% CI, 2.25, 4.62) of PC, and 3.85 (95% CI, 3.31, 4.48) of ESR, respectively. All three inflammatory indictors also predicted relapse-free survival (HRs > 2.0).

Conclusion

The systemic inflammatory response predicted poor survival in patients with renal cell carcinoma.

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Acknowledgments

The analysis was supported by National Natural Science Foundation of China (NSFC 30800401) and Shanghai university scientific selection and cultivation for outstanding young teachers in special fund (79301636). We thank the following persons for their help in the preparation of manuscript: Prof. Lihui Lai, Prof. Jiaying Liu, Miss Xiaorong Zhu and Dr. Zhongshi Liang from East China Normal University, Dr. Yuhang Zhao from Shanghai Integrated Circuit Research & Development Center, Prof. Chew-Kiat Heng from National University of Singapore, and Dr. Ying Xu from University of Pennsylvania.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Advanced Institute of NBIC Integrated Drug Discovery and Development, East China Normal University, North Zhongshan Road #3663, Shanghai, 200062, People’s Republic of China

    Ying Wu, Xiaonan Fu, Chao Zou, Yijie Han, Mingchu Xu & Yulan Zhao

  2. Central Laboratory, Wuhan Children’s Hospital, Wuhan, People’s Republic of China

    Xuelian He

  3. Department of Otorhinolaryngology, Peking Union Medical College Hospital, Beijing, People’s Republic of China

    Xiaoli Zhu

  4. Department of General Internal Medicine, Peking Union Medical College Hospital, Beijing, People’s Republic of China

    Chengjin Huang

  5. Department of Liver Surgery, Peking Union Medical College Hospital, Beijing, People’s Republic of China

    Xin Lu

  6. School of Life Science, East China Normal University, Shanghai, People’s Republic of China

    Mingchu Xu

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  1. Ying Wu
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  2. Xiaonan Fu
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  3. Xiaoli Zhu
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  4. Xuelian He
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  10. Yulan Zhao
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Corresponding author

Correspondence to Yulan Zhao.

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The authors Y. Wu and X. Fu contributed equally to this work.

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Wu, Y., Fu, X., Zhu, X. et al. Prognostic role of systemic inflammatory response in renal cell carcinoma: a systematic review and meta-analysis. J Cancer Res Clin Oncol 137, 887–896 (2011). https://doi.org/10.1007/s00432-010-0951-3

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  • DOI: https://doi.org/10.1007/s00432-010-0951-3

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