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t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa

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Abstract

Purpose

The t(11;18)(q21;q21) chromosome translocation is frequent in gastric MALT lymphoma, but the t(11;18)(q21;q21) chromosome translocation is very rare in other sites of MALT lymphomas. We investigated the possibility that MALT lymphoma occurred in the right buccal mucosa of a 66-year-old Japanese woman who had the t(11;18)(q21;q21) chromosome translocation.

Methods

Tumor specimens were examined by light microscopy and immunohistochemistry. To investigate where the present case has API-MALT1 fusion, we used the nested PCR and FISH analysis.

Results

Some colonized lymphoid follicles with mantle zone were observed on low-power field, and centrocyte-like cells and monocytoid B cells were observed on high-power field. Immunohistochemical staining of the tumor was positive for bcl-2, CD20, CD79a, CD43, Lambda, Kappa and was negative for CD10, IgG, IgG4, IgM, cyclin D1, bcl-6, CK (AE1/3), Helicobacter pylori. Using the nested PCR and FISH analysis, present case had the t(11;18)(q21;q21) chromosome translocation (A1446-M1150).

Conclusion

We report that MALT lymphoma in buccal mucosa has the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) by using the nested PCR and FISH analysis. This is the first report of the t(11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in the oral cavity.

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Fig. 1
Fig. 2

Abbreviations

MALT:

Mucosa-associated lymphoid tissue

PCR:

Polymerase chain reaction

FISH:

Fluorescence in situ hybridization

IgG:

Immunoglobulin G

IgM:

Immunoglobulin M

API2:

Apoptosis inhibitor 2

MALT1:

MALT lymphoma–associated translocation 1

NF-κB:

Nuclear factor-κB

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Acknowledgments

We thank Mr. Susumu Hashizume for assistance in performing FISH analysis and microscopic study.

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None.

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Authors and Affiliations

  1. Density and Oral Surgery, Shinjyo Tokusyukai Hospital, Shinjyo, Japan

    Toshiaki Tanaka

  2. Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, School of Medicine, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan

    Toshiaki Tanaka & Mituyoshi Iino

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  1. Toshiaki Tanaka
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  2. Mituyoshi Iino
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Correspondence to Toshiaki Tanaka.

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Tanaka, T., Iino, M. t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa. J Cancer Res Clin Oncol 136, 1783–1785 (2010). https://doi.org/10.1007/s00432-010-0939-z

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  • DOI: https://doi.org/10.1007/s00432-010-0939-z

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