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Clinical outcomes of advanced non-small cell lung cancer patients screened for epidermal growth factor receptor gene mutations

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Abstract

Purpose

To evaluate the relationship between the epidermal growth factor receptor (EGFR) mutation status and the effectiveness of gefitinib monotherapy or chemotherapy in patients with advanced non-small cell lung cancer (NSCLC).

Methods

We retrospectively analyzed a cohort of 100 patients with stage IIIB/IV NSCLC screened for two major EGFR mutations (exon 19 deletions and L858R mutation).

Results

Forty-six out of 48 EGFR mutation-positive patients (96%) received gefitinib, whereas only 3 out of 52 EGFR mutation-negative patients (6%) received gefitinib. Favorable objective response rates to gefitinib as first- and second-line treatment (87 and 80%, respectively) were observed in EGFR mutation-positive patients. Overall response rate to chemotherapy as first-line treatment did not differ significantly between patients with EGFR mutations and those without mutation (32 vs. 28%, respectively; P = 0.7198). As to first-line treatment, EGFR mutation-positive patients treated with gefitinib experienced significantly longer progression-free survival (PFS) than did patients who received chemotherapy (median survival, 7.8 months vs. 5.1 months, respectively; P = 0.0323). Similarly, as to second-line treatment, EGFR mutation-positive patients treated with gefitinib had significantly longer PFS than did patients who received chemotherapy (median survival, 6.5 months vs. 4.0 months, respectively; P = 0.0048). Patients with EGFR mutations survived longer than those without EGFR mutations after first-line treatment (median, 24.3 vs. 12.6 months, respectively; P = 0.0029).

Conclusion

EGFR mutation-positive patients benefit from either first- or second-line gefitinib monotherapy. Further large-scale prospective studies to confirm this finding are needed.

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Acknowledgment

We thank Noriko Shibata for her excellent technical assistance with the molecular genetic analysis of the EGFR mutations.

Conflict of interest statement

All authors have no financial or personal relationships with other people or organizations that could inappropriately influence our work.

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Authors and Affiliations

  1. Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Kimihide Yoshida, Jangchul Park, Shizu Ogawa, Ji Young Park, Junichi Shimizu, Yoshitsugu Horio & Toyoaki Hida

  2. Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Yasushi Yatabe

  3. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Keitaro Matsuo

  4. Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Tetsuya Mitsudomi

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  1. Kimihide Yoshida
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  2. Yasushi Yatabe
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  3. Jangchul Park
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  4. Shizu Ogawa
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  10. Toyoaki Hida
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Correspondence to Kimihide Yoshida.

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Yoshida, K., Yatabe, Y., Park, J. et al. Clinical outcomes of advanced non-small cell lung cancer patients screened for epidermal growth factor receptor gene mutations. J Cancer Res Clin Oncol 136, 527–535 (2010). https://doi.org/10.1007/s00432-009-0685-2

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  • DOI: https://doi.org/10.1007/s00432-009-0685-2

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