Abstract
Objective
To describe epidemiology and prognosis of head and neck cancer in Germany.
Methods
We analyzed the Thuringian cancer registry database from 1996 to 2005. 3,821 cases with primary head and neck cancer were evaluated for patient’s characteristics, tumor stage, incidence, treatment, and trends in overall survival.
Results
During the period 1996–2005, the incidence of oropharynx, hypopharynx, larynx, and salivary gland cancer increased significantly for males, and of oral cavity and hypopharynx cancer for females. There was a significant trend using more multimodal therapy combining surgery, radiotherapy, and chemotherapy, and to use less radiotherapy as a single modality. The median follow-up time of patients alive was 42 months. The 5-year overall survival rate (OS) for all patients was 47.8%. The site-specific 5-year OS for lip, oral cavity, nasopharynx, oropharynx, hypopharynx, larynx, salivary gland, and nose/paranasal sinus cancer was 75.7, 42.6, 43.5, 45.9, 27.2, 57.3, 61.0, and 34.9%, respectively. The multivariate analysis showed that male gender, age ≥60 years, therapy without surgery, higher T classification, N classification, and M classification were independent significant negative risk factors for OS (p < 0.0001). Cancer of the oral cavity and of the hypopharynx had a significant lower OS than lip cancer (p = 0.012 and p = 0.044, respectively). Comparing the periods 1996–2000 with the period 2001–2005, there was no significant improvement of OS for any subsite.
Conclusions
Many subsites of head and neck cancer have changing incidence. Although treatment strategies have changed, outcome has not improved significantly from 1995 to 2006.
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Acknowledgments
We like to thank all departments and outpatient clinics that were involved in the treatment and data collection of the patients. All departments are in Germany: Altenburg: Kreiskrankenhaus Altenburg gGmbH. Apolda: Robert-Koch-Krankenhaus Apolda. Arnstadt: Ilm-Kreis-Kliniken Arnstadt-Ilmenau; E. Remp, private practice. Aue: Helios Klinikum Aue. Bad Langensalza: Hufeland-Krankenhaus Bad Langensalza. Bad Hersfeld: Kreiskrankenhaus Bad Hersfeld. Bad Liebenstein: Kreiskrankenhaus Bad Liebenstein. Bad Salzungen: Klinikum Bad Salzungen. Bitterfeld: Kreiskrankenhaus Bitterfeld. Chemnitz: Klinikum Chemnitz gGmbH. Dessau: Staedtisches Klinikum. Dresden: University Hospital Dresden. Eisenach: St. Georg Klinikum Eisenach. Erfurt: H. Goebel, Tumor registry Erfurt; Helios Klinikum; H. Böttcher, private practice; Katholisches Krankenhaus St. Johann Nepomuk. Gera: R. Götze, tumor registry Gera; SRH Wald-Klinikum. Halberstadt: St.-Salvator-Krankenhaus. Goettingen: University Hospital Goettingen. Greiz: Kreiskrankenhaus Greiz. Halle: University Hospital Halle. Jena: A. Altendorf-Hofmann, tumor registry Jena; University Hospital Jena. Leipzig: Staedtisches Klinikum St. Georg; University Hospital Leipzig. Meiningen: R. Metzner, private practice, Nordhausen: K. Fernschild, tumor registry Suedharz; Südharz-Krankenhaus Nordhausen; H. Brandt, private practice. Oelsnitz: B. Zimmer, private practice. Plauen: Humaine Vogtland-Klinikum Plauen. Sondershausen: Kyffhäuser Krankenhaus Sondershausen; P. Surup, private practice. Suhl: M. Wackes, Tumor registry Suhl; SRH Klinikum Suhl. Weimar: Sophien- und Hufelandkliniken Weimar. Wuerzburg: University Hospital Wuerzburg. Zeitz: H Aleyt, private practice; Georg-Agricola-Klinikum Zeitz.
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Guntinas-Lichius, O., Wendt, T., Buentzel, J. et al. Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration database. J Cancer Res Clin Oncol 136, 55–63 (2010). https://doi.org/10.1007/s00432-009-0636-y
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DOI: https://doi.org/10.1007/s00432-009-0636-y