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Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience

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Abstract

Purpose

To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer.

Methods

Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2–50 Gy) and 2.5 Gy (range 1.8–3 Gy).

Results

The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy10 or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively.

Conclusion

Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.

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Authors and Affiliations

  1. Gastrointestinal Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Kenji Hashimoto, Atsuo Takashima, Takako Eguchi Nakajima, Ken Kato, Tetsuya Hamaguchi, Yasuhide Yamada & Yasuhiro Shimada

  2. Radiation Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Hiroshi Mayahara, Yoshinori Ito, Yoshikazu Kagami & Jun Itami

Authors
  1. Kenji Hashimoto
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  2. Hiroshi Mayahara
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  3. Atsuo Takashima
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  4. Takako Eguchi Nakajima
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  5. Ken Kato
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  6. Tetsuya Hamaguchi
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  7. Yoshinori Ito
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  8. Yasuhide Yamada
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  9. Yoshikazu Kagami
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  10. Jun Itami
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  11. Yasuhiro Shimada
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Corresponding author

Correspondence to Hiroshi Mayahara.

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Hashimoto, K., Mayahara, H., Takashima, A. et al. Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience. J Cancer Res Clin Oncol 135, 1117–1123 (2009). https://doi.org/10.1007/s00432-009-0553-0

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  • DOI: https://doi.org/10.1007/s00432-009-0553-0

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