Abstract
Purpose
Adenoid cystic carcinoma of the salivary gland (ACC-SG) is a slow-growing tumor that is refractory to most chemotherapeutic agents. Estrogen receptor (ER) antagonists provide a novel approach for recurrent disease.
Methods
We report two cases of ACC-SC in which Tamoxifen/Toremifene were used.
Results
Both patients obtained long-term stability of disease with no associated toxicity.
Conclusions
Given the relatively unsuccessful treatments for ACC-SC and the low toxicity of ER antagonists, such therapy should be considered in these patients for its potential disease-stabilizing effects.
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Elkin, A.D., Jacobs, C.D. Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases. J Cancer Res Clin Oncol 134, 1151–1153 (2008). https://doi.org/10.1007/s00432-008-0377-3
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DOI: https://doi.org/10.1007/s00432-008-0377-3