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Midkine as a prognostic marker for gastrointestinal stromal tumors

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Abstract

Purpose

Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The outcome of patients with gastrointestinal stromal tumors (GISTs) is correlated with tumor size and mitotic count. The aim of this study was to determine MK expression in GISTs.

Methods

Midkine was detected in 31 (55%) of 57 surgically resected GISTs by immunohistochemistry with a rabbit antibody against MK and peroxidase method.

Results

A significant worse outcome of MK-positive patients was found (P < 0.05; log rank test). Multivariate Cox regression analysis showed an independent prognostic impact (relative risk for overall survival 3.64; P < 0.05). Interestingly, MK expression was significantly associated with mitotic rate (P < 0.05; Chi-squared test), but not with tumor size (P = 0.97).

Conclusions

Taken together, MK is a prognostic marker for GIST patients. MK might also be a useful peripheral tumor marker since it can be detected in peripheral serum. Future studies should involve higher GIST patient numbers including tumor and serum samples for detection of MK.

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Acknowledgments

We thank Beate Roth for excellent technical assistance. Financial support for this study was provided by research grants from the Hamburger Krebsgesellschaft e. V. (J.T.K., E.F.Y., J.R.I.).

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Authors and Affiliations

  1. Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Jussuf T. Kaifi, Svanheidur L. Rafnsdottir, Paulus G. Schurr, Robin Wachowiak, Helge Kleinhans, Emre F. Yekebas, Oliver Mann, Tim Strate & Jakob R. Izbicki

  2. Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Henning C. Fiegel & Dietrich Kluth

  3. Institute for Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Uta Reichelt

  4. Department of Surgery, Kagoshima University, Kagoshima, Japan

    Kuniaki Aridome

  5. Department of Health Science, Faculty of Psychological and Physical Sciences, Aichi Gakuin University, Aichi, Japan

    Keiko Ichihara-Tanaka & Takashi Muramatsu

Authors
  1. Jussuf T. Kaifi
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  2. Henning C. Fiegel
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  3. Svanheidur L. Rafnsdottir
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  4. Kuniaki Aridome
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  5. Paulus G. Schurr
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  6. Uta Reichelt
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  7. Robin Wachowiak
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  8. Helge Kleinhans
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  9. Emre F. Yekebas
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  10. Oliver Mann
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  11. Keiko Ichihara-Tanaka
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  12. Takashi Muramatsu
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  13. Dietrich Kluth
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  14. Tim Strate
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  15. Jakob R. Izbicki
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Correspondence to Jussuf T. Kaifi.

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Kaifi, J.T., Fiegel, H.C., Rafnsdottir, S.L. et al. Midkine as a prognostic marker for gastrointestinal stromal tumors. J Cancer Res Clin Oncol 133, 431–435 (2007). https://doi.org/10.1007/s00432-006-0180-y

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  • DOI: https://doi.org/10.1007/s00432-006-0180-y

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