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Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives

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Abstract

Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. Many angiogenic factors have been studied in HCC, and several anti-angiogenic therapies have been tested in animal models and patients. This paper summarizes the latest findings, especially regarding the clinical significance of endothelial cell markers and angiogenic factors in HCC, and experimental and clinical anti-angiogenesis therapies. Further developments in this area, such as endothelial cell-oriented research and better experimental and clinical designs in the evaluation of anti-angiogenic therapies are discussed.

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  1. Liver Cancer Institute and Zhong Shan Hospital, Fudan University, #136 Yi Xue Yuan Road, 200032, Shanghai, P.R. China

    Hui-Chuan Sun & Zhao-You Tang

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  1. Hui-Chuan Sun
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Correspondence to Hui-Chuan Sun.

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This work was jointly supported by a grant from the Shanghai Clinical Center Project, the Promising Young Doctor of Shanghai grant, and the “Project 211” grant from the Ministry of Education of China

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Sun, HC., Tang, ZY. Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives. J Cancer Res Clin Oncol 130, 307–319 (2004). https://doi.org/10.1007/s00432-003-0530-y

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