Abstract
Information regarding three of the more common cystic fibrosis mutations is presented (ΔF508, G542X, N13031K) to support the concept of a geography associated with cystic fibrosis mutations. We present the hypothesis that a knowledge of the geography of cystic fibrosis mutations is important for an understanding of genotype-phenotype correlations, gene flow, historical population migration and cystic fibrosis screening.
Conclusion A new method of study of mankind's cultural spread is being revealed and the survival of the various mutations supports the concept that they may provide a selective advantage to the carrier.
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Received: 30 June 1999 / Accepted: 15 December 1999
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Dawson, K., Frossard, P. The geographic distribution of cystic fibrosis mutations gives clues about population origins. Eur J Pediatr 159, 496–499 (2000). https://doi.org/10.1007/s004310051317
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DOI: https://doi.org/10.1007/s004310051317