Abstract
We report on the clinical, laboratory, and molecular genetic findings in a 15-month-old boy who initially presented with disseminated cytomegalovirus and concomitant para-influenza virus infection. Hyper-IgM syndrome, suspected on clinical grounds, was confirmed by immunological investigations. In addition, a previously unreported potentially disease-causing mutation in the CD40 ligand gene was detected in this patient.
Conclusion The present case illustrates that disseminated cytomegalovirus infection with atypical clinical features should be included in the spectrum of the hyper-IgM syndrome.
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Received: 18 August 1999 and in revised form: 26 October 1999 / Accepted: 4 January 2000
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Benesch, M., Pfleger, A., Eber, E. et al. Disseminated cytomegalovirus infection as initial manifestation of hyper-IgM syndrome in a 15-month-old boy. Eur J Pediatr 159, 453–455 (2000). https://doi.org/10.1007/s004310051306
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DOI: https://doi.org/10.1007/s004310051306