Abstract
We report on a 9-year-old boy with the hyper-IgM syndrome who presented with rapid impairment of consciousness. The brain CT scan showed multiple round lucencies, and the brain histology revealed necrotizing toxoplasmic encephalitis. This patient, whose CD40/CD40 ligand system was impaired, indicates the importance of this system for defence against toxoplasmic infection.
Conclusion Although disseminated toxoplasmosis is a rare complication of the hyper-IgM syndrome, it must be included in the differential diagnosis of infections.
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Received: 31 July 1997 / Accepted in revised form: 9 February 1998
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Tsuge, I., Matsuoka, H., Nakagawa, A. et al. Necrotizing toxoplasmic encephalitis in a child with the X-linked hyper-IgM syndrome. Eur J Pediatr 157, 735–737 (1998). https://doi.org/10.1007/s004310050925
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DOI: https://doi.org/10.1007/s004310050925