Abstract
This paper aims to improve the diagnosis of syncope and transient loss of consciousness (TLOC) in children. Diagnostic problems stem, first, from some causes spanning various disciplines, e.g. cardiology, neurology and psychiatry, while the most common cause, vasovagal syncope, is not embraced by any specialty. Second, clinical variability is huge with overlapping signs and symptoms. Third, the approach to TLOC/syncope of the European Society of Cardiology (ESC) is underused in childcare. We explain the ESC guidelines using an additional paediatric literature review. Classification of TLOC and syncope is hierarchic and based on history taking. Loss of consciousness (LOC) is defined using three features: abnormal motor control including falling, reduced responsiveness and amnesia. Adding a < 5 min duration and spontaneous recovery defines TLOC. TLOC simplifies diagnosis by excluding long LOC (e.g. some trauma, intoxications and hypoglycaemia) and focussing on syncope, tonic–clonic seizures and functional TLOC. Syncope, i.e. TLOC due to cerebral hypoperfusion, is divided into reflex syncope (mostly vasovagal), orthostatic hypotension (mostly initial orthostatic hypotension in adolescents) and cardiac syncope (arrhythmias and structural cardiac disorders). The initial investigation comprises history taking, physical examination and ECG; the value of orthostatic blood pressure measurement is unproven in children but probably low. When this fails to yield a diagnosis, cardiac risk factors are assessed; important clues are supine syncope, syncope during exercise, early death in relatives and ECG abnormalities.
Conclusions: In adults, the application of the ESC guidelines reduced the number of absent diagnoses and costs; we hope this also holds for children.
What is Known: • Syncope and its mimics are very common in childhood, as they are at other ages. • Syncope and its mimics provide considerable diagnostic challenges. | |
What is New: • Application of the hierarchic framework of transient loss of consciousness (TLOC) simplifies diagnosis. • The framework stresses history-taking to diagnose common conditions while keeping an eye on cardiac danger signs. |
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Introduction
Syncope is common at all ages. Approximately 40% of all people experience at least one syncope in their life [1]. Syncope constitutes up to 3% of emergency department visits [1]. Syncope care is inefficient with inappropriate costly tests and admissions [1, 2]. A diagnosis is often not made, due to a limited overview of possible causes and inappropriate evaluation. Diagnostic failure is explicable since syncope and its mimics may be due to cardiological, neurological, medical or psychiatric disorders. Diagnosis is made even more difficult, firstly by inconsistent definitions that incorrectly include concussion, epilepsy, metabolic disorders, stroke, transient ischaemic attacks and other conditions such as syncope in adults and children [3,4,5]. Secondly, some classifications ignore helpful features such as the duration of unconsciousness [6].
Realization of such problems led the European Society of Cardiology (ESC) to produce multidisciplinary syncope guidelines [1] comparable to North American ones [7]. The resulting diagnostic strategy reduced the proportion of undiagnosed cases, increased the number of diagnoses of vasovagal syncope (VVS) and decreased inappropriate tests and costs [1].
Unfortunately, these guidelines appear to have had a limited impact on paediatric syncope care [1, 6]. A recent systematic review revealed so many definitions and classification problems that the authors called for more diagnostic consistency [4].
This paper aims to facilitate paediatric syncope diagnosis by focussing on the ESC hierarchical approach to childcare [1, 8]. As therapy follows diagnosis, it is not discussed, except for a brief mention of nonpharmacological measures.
Definitions
ESC definitions were formulated for pragmatic diagnostic utility (Table 1) [1], starting with clues to recognize the apparent loss of consciousness (LOC) through history-taking (Table 2), requiring three obligatory features:
-
1.
Loss of motor control: this always comprises a tendency to fall but also has variable features: tone is flaccid or stiff, eyes are open or closed, limbs and neck may be flexed or extended, myoclonic jerks are present or absent
-
2.
Loss of response to touch/speech
-
3.
Amnesia for the period of LOC
The presence of all three features guarantees that patients appear unconscious but do not prove gross cortical dysfunction as in syncope or generalized seizure, thus retaining functional causes.
The next step defines the major category ‘Transient Loss of Consciousness’ (TLOC) as LOC of brief duration with spontaneous recovery [1, 8]. Including eyewitness overestimation, a pragmatic maximum duration for TLOC is 5 min. Separating TLOC from other causes of LOC dramatically reduces the number of causes, mainly by excluding long-lasting LOC (Table 3, Fig. 1). To stress that the TLOC classification applies to all ages, all forms of TLOC are shown, but forms of little relevance to childcare are shown in grey and are not discussed in detail.
Syncope is defined pathophysiologically as TLOC due to global cerebral hypoperfusion [1] and not as a set of signs and symptoms, simply because no such set includes all syncope while excluding all epilepsy and psychogenic TLOC [9]. For instance, with syncope, facial colour may be pale, red, blue or normal; tone may be stiff or flaccid; movements may be present or absent. The resulting overlap of clues explains why syncope, epileptic seizures and functional TLOC are often mistaken for one another. Distinguishing them hardly ever rests on one clue, but instead on patterns of triggers, signs and symptoms [1, 8].
Diagnosing syncope requires a hierarchical procedure assessing the sequence of LOC, TLOC, syncope and type of syncope (Table 1) to achieve the most specific diagnosis the data permit.
Syncope partially overlaps with ‘orthostatic intolerance’, i.e. complaints while standing due to circulatory problems, as standing plays a role in vasovagal syncope and orthostatic hypotension. In postural orthostatic tachycardia syndrome (POTS), syncope appears no more common than in the general population and is commonly VVS [10].
Diagnosis
The diagnosis of TLOC and syncope consists of the initial evaluation, risk assessment and specific investigations, if needed [1].
Initial evaluation
History taking, physical examination, orthostatic blood pressure (BP) measurement, and ECG comprise the initial evaluation. History taking is crucial, first because circumstances, signs and symptoms provide crucial clues [1, 8], and second because tests performed in between spells are often normal. The most relevant clues are presented below; more are presented in the ESC practical guidelines [8]. ECG is rarely abnormal but warranted because of the rare chance of finding high-risk cardiac disease. The utility of conventional BP measurements before and after standing up in paediatric syncope is unknown but probably low. If no probable diagnosis can be made, risk assessment is required.
Risk assessment
Risk assessment (Table 4) aims at detecting cardiac disease [1]. Questions assessing risks can easily be combined with the initial evaluation (see below) [11]. High-risk cases should be admitted to the hospital, although in some cases, patients may be discharged with close follow-up, provided the patient and relatives understand the need to avoid triggering syncope, for instance by avoiding competitive sports. Low-risk cases do not need immediate admission or testing. Cases with intermediate risk can be admitted for observation or referred to a syncope unit [1, 12].
Forms of TLOC
Concussion
Head trauma-causing TLOC must be distinguished from TLOC-causing trauma by asking which came first. TLOC-causing concussion may complicate diagnosis if traumatic amnesia obscures memories of the event.
Syncope
The three major syncope groups are reflex, orthostatic hypotension and cardiac (Fig. 1). Triggers, posture and circumstances always play major roles, so a good first question is ‘what were you doing at the time?’. This should ascertain body position (lying, sitting, standing), the time spent in that position and the presence of any triggers.
There are two types of symptoms of impending syncope. The first is related to cerebral hypoperfusion, with visual changes (darkening, spots, loss of colour), hearing changes (distant sounds, tinnitus), light-headedness and LOC. These help establish syncope but not its cause. The second group suggests a cause, e.g. autonomic activation suggests reflex syncope (see below) and palpitations or chest pain suggest cardiac syncope.
As said, the tone may be stiff or flaccid, limbs may be flexed or extended and facial colour may be blue or pale, but the eyes are nearly always wide open during LOC [1, 8]. While the absence of jerking movements excludes tonic–clonic seizure, their mere presence does not differentiate syncope from seizure. Instead, their nature and number are useful: there are typically < 10 arrhythmic jerks in syncope and > 20 rhythmic jerks in tonic–clonic seizures [13].
Recovery from LOC in syncope typically only takes ~ 10 s. However, patients may feel fatigued/sleepy for hours afterward. Children may enter a deep sleep after syncope, usually after first regaining consciousness, unlike sleep in epilepsy which is often a continuation of LOC.
Reflex syncope
In reflex syncope, a trigger evokes ‘autonomic activation’ before LOC, comprising sweating, pallor, nausea, and rarely vomiting or diarrhoea. The circulatory response consists of two parts, both reducing blood pressure (Fig. 2):
-
1.
Vasodepression, i.e. vasodilation in muscle and splanchnic vascular beds causing venous pooling.
-
2.
Cardioinhibition, i.e. a vagal heart rate fall due to sinus slowing that may include asystole of usually < 20 s. Cardioinhibition decreases with age [14] but is very common in childhood. Asystole is probably ubiquitous in VVS in toddlers. Asystole during reflex syncope is not a cardiac emergency, and there is no evidence of a poor prognosis [15].
Reflex syncope comprises three subgroups: vasovagal syncope, carotid sinus syncope and situational syncope (Fig. 1).
Vasovagal syncope (VVS)
Triggers are prolonged standing (usually > 5 min) or emotional through pain or fear; syncope is aided by crowded environments, changes in temperature, heat (external or internal, i.e. fever), dehydration due to excessive loss or decreased intake (sweating, vomiting/diarrhoea, fluid avoidance) and stress [1]. Hyperventilation facilitates VVS but does not alone cause VVS. The combination of typical VVS triggers plus autonomic activation without high-risk signs makes VVS so likely that no tests are needed beyond an ECG as a safety measure [1]. Chest discomfort and palpitations are common in adolescents, possibly related to hyperventilation, and are unreliable discriminators for cardiogenic syncope. Postsyncopal fatigue/sleep and headache are common [16].
VVS is by far the most common form of paediatric syncope with a peak age of onset of ~ 15 years [17]. The chances of VVS decrease thereafter but increase over the age of 60. VVS occurs twice as often in female than male adolescents [17]. Syncope recurs in at least 1/3 of VVS patients. Attacks vary widely in presentation and frequency.
Carotid sinus syncope
Carotid sinus syncope is so rare in the young that it need not be considered in paediatrics.
Situational syncope
‘Situational syncope’ refers to reflex syncope with a specific trigger such as swallowing, defaecation, micturition and coughing. There is no fundamental pathophysiological difference from VVS. Two forms preferentially occur in adolescence: hair grooming syncope [18] and stretch syncope, induced by stretching arms and neck upwards and backwards [19].
Syncope due to orthostatic hypotension (OH)
In all three OH forms discussed below, the circulation fails to maintain BP while standing. VVS is also often triggered by standing, but autonomic activation is present in VVS and absent in OH [20]. There are almost always multiple triggers in a patient with VVS, including pain, whereas only standing evokes syncope in OH. BP is low in OH and VVS, but heart rate is low in reflex syncope and high or normal in OH [20].
Initial orthostatic hypotension (iOH)
iOH is very common in adolescents. In iOH, BP decreases immediately after standing and spontaneously recovers while patients remain standing (Fig. 2). Symptoms range from mild light-headedness to syncope with falls. The typical history is standing up from a chair, walking three or four steps and falling. Syncope develops so quickly that the last memory may be standing up and the next lying on the floor. Conventional BP devices are too slow to capture the rapid changes of iOH, requiring specific ‘beat-to-beat’ monitors. Abnormality thresholds [1, 7, 20] include a decrease of systolic BP > 40 mmHg and/or diastolic BP > 20 mmHg within 15 s of standing. iOH occurs in its fully developed form in 15–20% of cases and in attenuated form in ~ 50% of all children [21]. Symptoms can be prevented by ‘counter-manoeuvres’ [21, 22].
Classical and delayed orthostatic hypotension (cOH and dOH)
cOH and dOH are defined as a sustained fall in blood pressure while standing [1, 8]. The rarity of chronic cOH in children [23] suggests VVS and iOH as more likely causes of syncope during standing. When cOH is present, its causes parallel those in adults, including medication, type I diabetes and hypovolemia [23].
Cardiac syncope
Signs and symptoms
Cardiac syncope carries intermediate to high risk. Supine syncope is a cardiac danger sign because it suggests circulatory standstill: in most reflex syncope and OH, the circulation does not stop altogether, so lying or sitting alleviate complaints. When these do not help, a circulatory standstill implying cardiac syncope is more likely. VVS evoked by needles may well occur in patients already lying down and is then usually due to asystole causing a circulatory standstill, but not a dangerous one. Also note that epileptic seizures and functional TLOC may occur while lying. Syncope during exercise is also a danger sign, although this can also occur in VVS. Syncope just after exercise also carries risks: while occurring often in VVS (and cOH), it also occurs in arhythmic syncope [24]. Exercise stress testing is essential. Always ask for unexpected deaths in family members of < 40 years, as these suggest inherited cardiomyopathy or arrhythmia [1].
An ECG is essential, as many cases of cardiac syncope occur in existing although undetected structural heart disease. Most ECG abnormalities are relevant, although evidence of ischemia is rare in paediatrics (anomalous coronary artery). Echocardiography is necessary if the history suggests cardiac syncope, even with normal ECG.
Arrhythmia
Syncope from primary arrhythmia is typically due to abnormally high heart rate (‘tachyarrhythmia’), rarely due to low HR (‘bradyarrhythmia’). Diagnosis can be made by extended external or internal ECG loop recording (ILR) [25]. When myocardial function is normal, HR must be extremely high for syncope to occur, although standing increases the chance, by decreasing venous return. Most paediatric supraventricular tachycardias (SVT) and many ventricular tachycardias (VT) are tolerated with mild symptoms and palpitations. In contrast, very rapid VT, as seen with many channelopathies, cause syncope if lasting more than 3–5 s. There are typically no prodromes, so LOC occurs without warning. If a tachyarrhythmia with syncope reverts spontaneously to sinus rhythm, consciousness is rapidly regained. When episodes last < 30 s, the patient appears normal immediately and asks, ‘What happened?’ without recall of onset; this suggests an arrhythmic cause. If LOC due to arrhythmia is ended by resuscitation, this should be termed ‘aborted sudden cardiac death’, not syncope, as underlying causes differ.
Arrhythmic syncope in children and adolescents is often due to genetic causes. The resting ECG may contain clues, such as prolonged/abnormal QT interval. Inherited arrhythmic syncope may have specific triggers, e.g. startle such as by loud noise or cold water on the face (long QT syndrome), sudden onset syncope during fever (Brugada syndrome) and syncope during exercise/excitement (catecholaminergic polymorphic VT or arrhythmogenic right ventricular cardiomyopathy) [8].
Structural cardiovascular disease
Structural disease can cause syncope if cardiac output becomes insufficient to meet metabolic demands. Echocardiography is required. In children, causes include aortic stenosis, coarctation of the aorta, anomalous coronary arteries, tetralogy of Fallot and transposition of great arteries. Many congenital heart diseases especially those with a ventricular surgical scar can trigger arrhythmia, and residual heart disease can trigger cardiac syncope. Conditions presenting more commonly in adolescence are primary pulmonary hypertension and hypertrophic or dilated cardiomyopathy.
Epileptic seizures
Syncope is the most common cause of misdiagnosis of epileptic seizures [26], with futile anti-epileptic medication as a serious consequence.
Not all seizures cause TLOC
LOC in syncope and tonic–clonic seizures is due to a global cortical dysfunction [27], while the dysfunction is only partial in other seizure types. A fundamental clue is whether patients remain upright: in the absence of seizures of childhood and some focal seizures, responsiveness and memory are affected, but patients remain upright, which excludes TLOC. Only epilepsy types that cause falls result in TLOC, tonic–clonic seizures being the most common.
Clinical features of tonic–clonic seizures
Tonic–clonic seizures are rarely triggered but often have specific prodromes, the aura. Auras differ between patients but are stereotypical within patients: déjà vu and unpleasant smell or taste are common. During the aura, patients may show abnormal responsiveness but are upright, so this phase is not TLOC; TLOC then starts with the seizure becoming generalised, which may start with a cry and a stiff fall. Eyes are wide open as in syncope. There are 20–100 repetitive jerking movements [13]. A lateral tongue bite is specific (in syncope the tongue tip may be bitten) [1, 8]. The face may turn blue as in cardiac syncope. Once jerks are over, patients may enter deep sleep for many minutes. Once awake, patients do not comprehend the situation and may repeat questions, in contrast to syncope. Urinary incontinence, eye-opening, fatigue and sleep afterwards occur in syncope and seizures and thus are of limited diagnostic use [8].
Seizure-causing syncope and vice versa
In ‘ictal asystole’ cortical seizure activity causes asystole. A focal seizure develops as typical for that patient but suddenly ends with a fall with complete unconsciousness, i.e. syncope [28, 30]. Ictal asystole can occur at any age [29] but happens only in a fraction of a patient's seizures [30].
Syncope in infants can rarely trigger a tonic–clonic seizure; these events have been termed ‘anoxic epileptic seizures’ [31].
Psychogenic/functional TLOC
There are two types: in psychogenic pseudosyncope (PPS), patients lie still, superficially resembling syncope, while jerking movements resemble seizures in psychogenic nonepileptic seizures (PNES) [1, 8].
Strong clues are frequent episodes (many/week or daily), long (> 10 min) attacks and consistently closed eyes [32]. Physical injury does not exclude psychogenic TLOC. During spells, blood pressure and heart rate are likely to be high rather than low [32] (Fig. 2), and EEG and cerebral blood flow are normal [1, 32]. Documenting the nature of attacks increases diagnostic accuracy [33]. Video recording of a spell is often successful because of the high frequency and long duration of attacks, allowing scrutiny of muscle tone, movements and eye closure. Provoking a spell in the hospital allows documentation of physiological signals. For PNES, video-EEG is the gold standard, while for PPS, this is tilt testing with video-EEG, heart rate, blood pressure or records of cerebral perfusion [34]. Both types occur in adolescence and young adults and are more frequent in females than males. Attacks are often not triggered and can occur when supine, and there is no autonomic activation. In PPS, body position resembles sleep. Facial colour is normal, and patients lie more still than in VVS [32]. Patients with PPS often also have VVS and patients with PNES frequently also have epileptic seizures.
Other TLOC forms
‘Reflex anoxic seizures’ and ‘breath-holding spells’
Both terms refer to TLOC in infants/toddlers. The word ‘seizure’ in reflex anoxic seizures may suggest epilepsy, but the spells are in fact cardioinhibitory VVS with asystole, evoked by unpleasant or surprising stimuli. To avoid confusion, ESC Guidelines recommend ‘VVS in infants’ [1, 8].
A typical episode comprises a trigger, a fall, no cry, a child lying still, eyes open and upwards, stiffening with rigid extension and a few jerks [35].
Pallid and cyanotic types of breath-holding spells describe facial colour during an attack [36]. Both start at ~ 10 months of age. Pallid breath-holding is synonymous with ‘reflex anoxic seizures’, i.e. VVS in infants [37], so ‘breath-holding’ is a misnomer for these events. In contrast, respiration plays a role in ‘cyanotic breath-holding spells’ [38]. Startle or sudden hurt causes a reflex to stop respiration in expiration involuntarily, with secondary circulatory impairment. Reports of pallid and cyanotic spells occurring in the same child [39] suggest the two types are not mutually exclusive.
Other TLOC forms
True short-lived LOC can occur in subarachnoid haemorrhage and other rare disorders in adults, but these are rare in childcare.
Notes on therapy of iOH and VVS
Nonpharmacological means to prevent syncope are the mainstay of therapy of iOH and VVS and should be taught to all patients; they are explained on page e74 of the ESC Guidelines Practical Instructions [40]. None has been proven in children. For VVS, long-term increased water and salt intake or bolus water ingestion for risk situations (e.g. standing a long time) aims to prevent low blood pressure. When syncope is imminent, lying down is the best option, followed by sitting or manoeuvres to increase blood pressure, such as forceful leg crossing. Specific iOH measures are not to walk away immediately after standing up but to wait and to sit down or perform leg-crossing if symptoms appear [21, 22].
Instructing the correct performance of such measures should be part of teaching physicians about syncope, further helped by the practical instructions [40], free webmaterial along ESC guidelinesFootnote 1 or courses to improve communication about syncope [41].
Conclusions
A hierarchical framework to diagnose syncope is presented, resting on the determination of first LOC, then TLOC, syncope and the type of syncope. This framework, common to all specialties, encourages a broad diagnostic view, comprising all forms of syncope, epileptic seizures and psychogenic TLOC. Vasovagal syncope may be considered as much a part of paediatric medicine as it is part of cardiology, neurology and other specialties. The use of a common framework improves diagnosis and care at all ages.
Abbreviations
- BP:
-
Blood pressure
- cOH:
-
Classical orthostatic hypotension
- dOH:
-
Delayed orthostatic hypotension
- ECG:
-
Electrocardiogram
- EEG:
-
Electroencephalogram
- ESC:
-
European society of cardiology
- ILR:
-
Implantable loop recorder
- iOH:
-
Initial orthostatic hypotension
- LOC:
-
Loss of consciousness
- OH:
-
Classical orthostatic hypotension
- PNES:
-
Psychogenic nonepileptic seizures
- PPS:
-
Psychogenic pseudosyncope
- SVT:
-
Supraventricular tachycardia
- TLOC:
-
Transient loss of consciousness
- VT :
-
Ventricular tachycardia
- VVS:
-
Vasovagal syncope
References
Brignole M, Moya A, de Lange FJ et al (2018) 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J 39:1883–1948
Sun BC (2013) Quality-of-life, health service use, and costs associated with syncope. Prog Cardiovasc Dis 55(4):370–375
Winder MM, Marietta J, Kerr LM et al (2021) Reducing unnecessary diagnostic testing in pediatric syncope: a quality improvement initiative. Pediatr Cardiol 42(4):942–950. https://doi.org/10.1007/s00246-021-02567-4. Epub 2021 Feb 13 PMID: 33582873
Zavala R, Metais B, Tuckfield L, DelVecchio M, Aronoff S (2020) Pediatric syncope: a systematic review. Pediatr Emerg Care 36(9):442–445
Villafane J, Miller JR, Glickstein J et al (2021) Loss of consciousness in the young child. Pediatr Cardiol 42(2):234–254
van Dijk JG, Benditt DG, Fanciulli A et al (2020) Towards a common definition of syncope in children and adults (Letter). Ped Emerg Care. https://doi.org/10.1097/PEC.0000000000002309
Shen W-K, Sheldon RS, Benditt DG et al (2017) 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society. Circulation 136:e60–e122
Brignole M, Moya A, de Lange FJ, ESC scientific document group. Practical instructions for the, et al (2018) ESC guidelines for the diagnosis and management of syncope. Eur Heart J 2018(39):e43–e80
Saal DP, van Dijk JG (2014) Classifying syncope. Auton Neurosci 184:3–9
Olshansky B, Cannom D, Fedorowski A et al (2020) Postural orthostatic tachycardia syndrome (POTS): a critical assessment. Prog Cardiovasc Dis 63(3):263–270
Numeroso F, Casagranda I (2021) How to simplify the implementation of syncope ESC guidelines in the emergency department and get on the road to achieve “zero inappropriate admissions.” Minerva Med. https://doi.org/10.23736/S0026-4806.21.07580-7
Kenny RA, Brignole M, Dan G-A et al (2015) Syncope Unit: rationale and requirement–the European Heart Rhythm Association position statement endorsed by the Heart Rhythm Society. Europace 17:1325–1340
Shmuely S, Bauer PR, van Zwet EW, van Dijk JG, Thijs RD (2018) Differentiating motor phenomena in tilt-induced syncope and convulsive seizures. Neurology 90:e1339–e1346
van Dijk JG, van Rossum IA, van Houwelingen M, Ghariq M, Saal DP, de Lange FJ, Thijs RD, Sutton R, Benditt DG (2022) Influence of age on magnitude and timing of vasodepression and cardioinhibition in tilt-induced vasovagal syncope. JACC Clin Electrophysiol 8(8):997–1009. https://doi.org/10.1016/j.jacep.2022.05.009. Epub 2022 Jul 27 PMID: 35981805
Sau A, Mereu R, Taraborelli P et al (2015) A long-term follow-up of patients with prolonged asystole of greater than 15s on head-up tilt testing. Int J Cardiol 203:482–485
Ocon AJ, Messer Z, Medow MS, Stewart JM (2011) Increased pulsatile cerebral blood flow, cerebral vasodilation, and postsyncopal headache in adolescents. J Pediatr 159:656-662.e1
Ganzeboom KS, Colman N, Reitsma JB, Shen WK, Wieling W (2003) Prevalence and triggers of syncope in medical students. Am J Cardiol 91:1006–1008
Evans WN, Acherman R, Kip K, Restrepo H (2009) Hair-grooming syncope in children. Clin Pediatr [Phila] 48:834–836
Mazzuca M, Thomas P (2007) Self-induced stretch syncope of adolescence: a video-EEG documentation. Epileptic Disord 9:413–417
Ghariq M, Kerkhof FI, Reijntjes RH, Thijs RD, van Dijk JG (2021) New hemodynamic criteria to separate classical orthostatic hypotension from vasovagal syncope. Ann Clin Transl Neurol (8):1635–1645. https://doi.org/10.1002/acn3.51412. Epub 2021 Jun 24. PMID: 34166574; PMCID: PMC8351382
Tanaka H, Yamaguchi H, Matushima R, Tamai H (1999) Instantaneous orthostatic hypotension in children and adolescents: a new entity of orthostatic intolerance. Pediatr Res 46:691–696
Krediet CT, Go-Schon IK, Kim YS, Linzer M, van Lieshout JJ, Wieling W (2007) Management of initial orthostatic hypotension: lower body muscle tensing attenuates the transient arterial blood pressure decrease upon standing from squatting 1. Clin Sci [Lond] 113:401–407
Sukul D, Chelimsky TC, Chelimsky G (2012) Pediatric autonomic testing: retrospective review of a large series. Clin Pediatr [Phila] 51(1):17–22. https://doi.org/10.1177/0009922811415102. Epub 2011 Aug 25
Zorzi A, Cipriani A, Corrado D (2018) Circumstances of cardiac arrest during sports activity recorded on video. Eur J Prev Cardiol 25(13):1452–1454. https://doi.org/10.1177/2047487318791289
Varma N, Cygankiewicz I, Turakhia M, Heidbuchel H, Hu Y, Chen LY, Couderc JP, Cronin EM, Estep JD, Grieten L, Lane DA (2021) ISHNE/HRS/EHRA/APHRS expert collaborative statement on mHealth in arrhythmia management: digital medical tools for heart rhythm professionals: from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society. Circulation: Arrhythmia and Electrophysiology 14(2):e009204. https://doi.org/10.1161/CIRCEP.120.009204
Xu Y, Nguyen D, Mohamed A, Carcel C, Li Q, Kutlubaev MA, Anderson CS, Hackett ML (2016) Frequency of a false positive diagnosis of epilepsy: a systematic review of observational studies. Seizure 41:167–174. https://doi.org/10.1016/j.seizure.2016.08.005. Epub 2016 Aug 23 PMID: 27592470
van Dijk JG (2020) The meaning of ‘consciousness’ in syncope and related disorders In: Syncope. An evidence-based approach. Brignbole M, Benditt DG [Eds] Springer Nature Switzerland AG 17–32
Schuele SU, Bermeo AC, Alexopoulos AV et al (2007) Video-electrographic and clinical features in patients with ictal asystole. Neurology 69:434–441
Tényi D, Gyimesi C, Kupó P et al (2017) Ictal asystole: a systematic review. Epilepsia 58(3):356–362
van der Lende M, Surges R, Sander JW, Thijs RD (2016) Cardiac arrhythmias during or after epileptic seizures. J Neurol Neurosurg Psychiatry 87:69–74
Horrocks IA, Nechay A, Stephenson JB, Zuberi SM (2005) Anoxic-epileptic seizures: observational study of epileptic seizures induced by syncopes. Arch Dis Child 90:1283–1287
Tannemaat M, van Niekerk J, Reijntjes R, Thijs RD, Sutton R, van Dijk JG (2013) The semiology of tilt-induced psychogenic pseudosyncope. Neurology 15:1070–1118. https://doi.org/10.1212/WNL.0b013e3182a1aa88
LaFrance WC Jr, Baker GA, Duncan R, Goldstein LH, Reuber M (2013) Minimum requirements for the diagnosis of psychogenic nonepileptic seizures: a staged approach: a report from the International League Against Epilepsy Nonepileptic Seizures Task Force. Epilepsia 54(11):2005–2018
Thijs RD, Brignole M, Falup Pecurariu C et al (2021) Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness. Clin Autonom Res. https://doi.org/10.1007/s10286-020-00738-6
Stephenson JB (1978) Reflex anoxic seizures [‘white breath-holding’]: nonepileptic vagal attacks. Arch Dis Child 53(3):193–200
Lombroso CT, Lerman P (1967) Breathholding spells [cyanotic and pallid infantile syncope]. Pediatrics 39:563–581
Stephenson JB (2007) Clinical diagnosis of syncopes [including so-called breath- holding spells] without electroencephalography or ocular compression. J Child Neurol 22(4):502–508
Breningstall GN (1996) Breath-holding spells. Pediatr Neurol 14:91–97
DiMario FJ Jr (2001) Prospective study of children with cyanotic and pallid breath-holding spells. Pediatrics 107(2):265–269
Brignole M, Moya A, de Lange FJ, Deharo JC, Elliott PM, Fanciulli A,Fedorowski A, Furlan R, Kenny RA, Martín A, Probst V, Reed MJ, Rice CP, Sutton R, Ungar A, van Dijk JG (2018) ESC Scientific Document Group. Practical instructions for the 2018 ESC guidelines for the diagnosis and management of syncope. Eur Heart J 39(21):e43-e80. https://doi.org/10.1093/eurheartj/ehy071. PMID: 29562291
Stave EA, Greenberg L, Hamburger E, Ottolini M, Agrawal D, Lewis K, Barber JR, Bost JE, Harahsheh AS (2022) An educational intervention to facilitate appropriate subspecialty referrals: a study assessing resident communication skills. BMC Med Educ 22(1):533. https://doi.org/10.1186/s12909-022-03592-4.PMID:35804336;PMCID:PMC9270829
Funding
Julian M. Stewart received support in part by R56HL162752 and past support R01HL112736 from the NHLBI. Seshadri Balaji received a research grant from Medtronic and is a consultant for Milestone Pharmaceuticals. J. Gert van Dijk and Richard Sutton declare that no funds, grants or other support were received during the preparation of this manuscript.
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All authors contributed to the paper. J. Gert van Dijk and Richard Sutton were members of the ESC guidelines on syncope on which the present paper is based. The first draft of the manuscript was jointly written by all authors, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Stewart, J.M., van Dijk, J.G., Balaji, S. et al. A framework to simplify paediatric syncope diagnosis. Eur J Pediatr 182, 4771–4780 (2023). https://doi.org/10.1007/s00431-023-05114-w
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DOI: https://doi.org/10.1007/s00431-023-05114-w