References
Pels A, Derks J, Elvan-Taspinar A, van Drongelen J, de Boer M, Duvekot H, van Laar J, van Eyck J, Al-Nasiry S, Sueters M et al (2020) Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial. JAMA Netw Open 3:e205323
Russo FM, Hooper S, Tibboel D, DeKoninck P, Benachi A, Tréluyer JM, Allegaert K, Kumar S, Deprest J (2019) Antenatal therapy with sildenafil: don’t throw the baby out with the bathwater. Ultrasound Obstet Gynecol 53:274–275
Pels A, Onland W, Berger RMF, van Heijst AFJ, Lopriore E, Reiss IKM, Limpens J, Gordijn SJ, Ganzevoort W (2022) Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study. Eur J Pediatr 181:1709–1718
Sharp A, Cornforth C, Jackson R, Harrold J, Turner MA, Kenny LC, Baker PN, Johnstone ED, Khalil A, von Dadelszen P et al (2018) Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial. Lancet Child Adolesc Health 2:93–102
Groom KM, McCowan LM, Mackay LK, Lee AC, Gardener G, Unterscheider J, Sekar R, Dickinson JE, Muller P, Reid RA et al (2019) STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction. BJOG 126:997–1006
Nakanishi H, Suenaga H, Uchiyama A, Kusuda S (2018) Persistent pulmonary hypertension of the newborn in extremely preterm infants: a Japanese cohort study. Arch Dis Child Fetal Neonatal Ed 103:F554-f561
Russo FM, Toelen J, Eastwood MP, Jimenez J, Miyague AH, Vande Velde G, DeKoninck P, Himmelreich U, Vergani P, Allegaert K, Deprest J (2016) Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia. Thorax 71:517–525
Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z et al (2011) Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 123:2120–2131
Mous DS, Kool HM, Buscop-van Kempen MJ, Koning AH, Dzyubachyk O, Wijnen RMH, Tibboel D, Rottier RJ (2016) Clinically relevant timing of antenatal sildenafil treatment reduces pulmonary vascular remodeling in congenital diaphragmatic hernia. Am J Physiol-Lung Cell Mole Physiol 311:L734–L742
Author information
Authors and Affiliations
Contributions
FMR and FDB wrote the main manuscript text. EAP, KA, and JDP reviewed and critically contributed to the manuscript.
Corresponding author
Ethics declarations
Ethics approval
Not applicable.
Consent to participate
Not applicable.
Consent for publication
Not applicable.
Conflict of interest
The authors declare no competing interests.
Additional information
Communicated by Daniele De Luca
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Russo, F.M., De Bie, F.R., Partridge, E.A. et al. The antenatal sildenafil STRIDER trial for severe fetal growth restriction, are post hoc reflections ad rem?. Eur J Pediatr 181, 3775–3776 (2022). https://doi.org/10.1007/s00431-022-04569-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00431-022-04569-7