Skip to main content
Log in

The antenatal sildenafil STRIDER trial for severe fetal growth restriction, are post hoc reflections ad rem?

  • Correspondence
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Pels A, Derks J, Elvan-Taspinar A, van Drongelen J, de Boer M, Duvekot H, van Laar J, van Eyck J, Al-Nasiry S, Sueters M et al (2020) Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial. JAMA Netw Open 3:e205323

    Article  Google Scholar 

  2. Russo FM, Hooper S, Tibboel D, DeKoninck P, Benachi A, Tréluyer JM, Allegaert K, Kumar S, Deprest J (2019) Antenatal therapy with sildenafil: don’t throw the baby out with the bathwater. Ultrasound Obstet Gynecol 53:274–275

    Article  CAS  Google Scholar 

  3. Pels A, Onland W, Berger RMF, van Heijst AFJ, Lopriore E, Reiss IKM, Limpens J, Gordijn SJ, Ganzevoort W (2022) Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study. Eur J Pediatr 181:1709–1718

    Article  CAS  Google Scholar 

  4. Sharp A, Cornforth C, Jackson R, Harrold J, Turner MA, Kenny LC, Baker PN, Johnstone ED, Khalil A, von Dadelszen P et al (2018) Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial. Lancet Child Adolesc Health 2:93–102

    Article  Google Scholar 

  5. Groom KM, McCowan LM, Mackay LK, Lee AC, Gardener G, Unterscheider J, Sekar R, Dickinson JE, Muller P, Reid RA et al (2019) STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction. BJOG 126:997–1006

    CAS  PubMed  Google Scholar 

  6. Nakanishi H, Suenaga H, Uchiyama A, Kusuda S (2018) Persistent pulmonary hypertension of the newborn in extremely preterm infants: a Japanese cohort study. Arch Dis Child Fetal Neonatal Ed 103:F554-f561

    Article  Google Scholar 

  7. Russo FM, Toelen J, Eastwood MP, Jimenez J, Miyague AH, Vande Velde G, DeKoninck P, Himmelreich U, Vergani P, Allegaert K, Deprest J (2016) Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia. Thorax 71:517–525

    Article  Google Scholar 

  8. Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z et al (2011) Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 123:2120–2131

    Article  CAS  Google Scholar 

  9. Mous DS, Kool HM, Buscop-van Kempen MJ, Koning AH, Dzyubachyk O, Wijnen RMH, Tibboel D, Rottier RJ (2016) Clinically relevant timing of antenatal sildenafil treatment reduces pulmonary vascular remodeling in congenital diaphragmatic hernia. Am J Physiol-Lung Cell Mole Physiol 311:L734–L742

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

FMR and FDB wrote the main manuscript text. EAP, KA, and JDP reviewed and critically contributed to the manuscript.

Corresponding author

Correspondence to Francesca M. Russo.

Ethics declarations

Ethics approval

Not applicable.

Consent to participate

Not applicable.

Consent for publication

Not applicable.

Conflict of interest

The authors declare no competing interests.

Additional information

Communicated by Daniele De Luca

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Russo, F.M., De Bie, F.R., Partridge, E.A. et al. The antenatal sildenafil STRIDER trial for severe fetal growth restriction, are post hoc reflections ad rem?. Eur J Pediatr 181, 3775–3776 (2022). https://doi.org/10.1007/s00431-022-04569-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00431-022-04569-7

Navigation