We read with great interest the article by Simental-Mendía et al. [1] that authors had shown triglyceride-glucose (TyG) index has a high sensitivity and specificity to detect impaired fasting glucose, impaired glucose tolerance, and also type 2 diabetes. However, in their article, certain points should have been considered and some possible errors should be rectified.

Simental-Mendía et al. [1] mentioned an article in 2008 [2] as the reference they used to calculate the TyG index. This reference used this following formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Apparently, Simental-Mendía et al. [1] used this following slightly different formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL])/2, unlike their reference, possibly by mistake. So new calculations and new results might be expected by using the correct formula. Or if they just wrote a wrong formula in subheading “measurements” of their article or there is any reason to use a different formula, they should clarify.

Another key factor in using the TyG index is the real practical value of this index in the clinical practice. As the authors had previously stated [3], use of TyG index can be considered valuable, only if it adds to the current prognostic values of fasting glucose and triglyceride values. If Simental-Mendía et al. [1] could provide different sets of statistical analysis in which they only use fasting glucose or triglyceride\ levels with the same statistical settings they used in their article, and compare them with each other, readers and future investigators could see whether the use of TyG index is justifiable or not.