Abstract
The aim of this study was to assess demographic data, clinical presentation, metabolic features, and treatment in 76 children with urolithiasis presented from 2002 to 2011. Urolithiasis is responsible for 2.5/1,000 pediatric hospitalizations, with new cases diagnosed in 1.1/1,000 admissions. From the observed period, two-fold rise of incidence rate was observed. Compiling the data from other pediatric institutions in our country, we estimated present overall incidence rate in Croatia as 6.5/100,000 children under 18 years. There were 41 boys and 35 girls (ratio 1.17:1). The mean age at diagnosis was 9.7 (range 0.8–16) years and follow-up duration was 5.3 (range 1.8–10) years. Renal colic (75.0 %) and hematuria (57.89 %) were the main symptoms. In 65.78 % of children, stones were unilateral. Stones were located in kidney in 52.63 %, in the ureter in 26.32 %, and in bladder in 6.58 % cases. Stone analysis showed calcium oxalate in 75.0 % of the cases. Associated urinary tract abnormalities were found in 19.73 % children. Most common metabolic disturbances were hypercalciuria (47.37 %) and idiopathic or mild hyperoxaluria (18.42 %). Urine saturation (EQUIL2) was elevated in 61.84 % cases. Spontaneous stone evacuation occurred in 51.21 % children. Extracorporeal shock wave lithotripsy, surgical evacuation, and endoscopic removal of calculi were performed in 21.0, 6.58, and 5.26 % of cases, respectively. Follow-up conservative therapy, consisting of fluid/diet recommendations and additional potassium citrate and/or chlorothiazide in children with increased risk, was sufficient for stone recurrence prevention in 92.1 % of children. In conclusion, the study gave insight in epidemiology and metabolic disturbances of urinary stone disease in Croatian children.
Similar content being viewed by others
References
Alon US (2009) Medical treatment of pediatric urolithiasis. Pediatr Nephrol 24(11):2129–2135
Alpay H, Ozen A, Gokce I, Biyikli N (2009) Clinical and metabolic features of urolithiasis and microlithiasis in children. Pediatr Nephrol 24:2203–2209
Assimos DG, Holmes RP (2000) Role of diet in the therapy of urolythiasis. Urol Clin North Am 27(2):255–268
Bak M, Ural R, Agin H, Serdaroglu E, Calkavur S (2009) The metabolic etiology of urolithisis in Turkish children. Int Urol Nephrol 41:453–460
Bastuğ F, Gündüz Z, Tülipar S, Poyrazoglu H, Düsünsel R (2012) Urolithiasis in infants: evaluation of risk factors. World J Urol. doi:10.1007/s00345-012-0828-y
Batinić D, Milošević D, Blau N, Konjevoda P, Štambuk N, Barbarić V et al (2000) Value of the stone promoters/inhibitors ratios in the estimation of the risk of urolithiasis. J Chem Comput Sci 40(3):607–610
Biocić M, Saraga M, Kuzmić AC, Bahtijarević Z, Budimir D, Todorić J et al (2003) Pediatric urolythiasis in Croatia. Coll Antropol 27(2):745–752
Borghi L, Meschi T, Amato F, Briganti A, Navarini A, Giannini A (1996) Urine volume, water and recurrences in idiopathic calcium nephrolithiasis. A 5-year randomized prospective study. J Urol 155:839–843
Bush NC, Xu L, Brown BJ, Holzer MS, Gingrich A, Schuler B, Long L et al (2010) Hospitalizations for pediatric stone disease in United States, 2002–2007. J Urol 183:1151–1156
Clayton DB, Pope JC (2011) The increasing pediatric stone disease problem. Ther Adv Urol 3(1):3–12
Copelovitch L (2012) Urolithiasis in children. Pediatr Clin North Am 59(4):881–896
Defoor W, Asplin J, Jackson E, Jackson C, Reddy P, Sheldon C, Erhard M, Minevich E (2006) Urinary metabolic evaluations in normal and stone forming children. J Urol 176:1793–1796
DeFoor WR, Jackson E, Minevich E, Caillat A, Reddy P, Sheldon C, Asplin J (2010) The risk of recurrent urolithiasis in children is dependent on urinary calcium and citrate. Urology 76:242–245
Domrongkitchaiporn S, Stitchantracul W, Kochakarn W (2006) Causes of hypocitraturia in recurrent calcium stone formers: focusing on urinary potassium excretion. Am J Kidney Dis 48(4):546–554
Dursun I, Poyrazoglu HM, Dusunsel R, Gunduz Z, Gurgoze MK, Demirci D et al (2008) Pediatric urolithiasis: an 8-year experience of single centre. Int Urol Nephrol 40(1):3–9
Erbagci A, Erbagci AB, Yilmaz M, Yagci F, Trakcioglu M, Yurtseven C et al (2003) Pediatric urolithiasis—evaluation of risk factors in 95 children. Scand J Urol Nephrol 37:129–133
Faerber GJ (2001) Pediatric urolithiasis. Urology 11:385–389
Granberg CF, Baker LA (2012) Urolithiasis in children: surgical approach. Pediatr Clin North Am 59(4):897–908
Gürgöze MK, Sari MY (2011) Results of medical treatiment and metabolic risk factors in children with urolithiasis. Pediatr Nephrol 26:933–937
Gür-Güven A, Koyun M, Baysal YE, Akman S, Alimoglu E, Akbas H et al (2010) Urolithiasis in the first year of life. Pediatr Nephrol 25:129–134
Hoppe B, Kemper MJ (2010) Diagnostic examination of the child with urolithiasis or nephrocalcinosis. Pediatr Nephrol 25:403–413
Kalorin CM, Zabinski A, Okpareke I, White M, Kogan BA (2009) Pediatric urinary stone disease. Does age matter? J Urol 181:2267–2271
Kant AK, Graubard BI (2010) Contributors of water intake in US children and adolescents: associations with dietary and and meal characteristics—National Health and Nutrition Examination Survey 2005–2006. Am J Clin Nutr 92:887–896
Kovacevic L, Wolfe-Christiansen C, Edwards L, Sadraps M, Lakshmanan Y (2012) From hypercalciuria to hypocitraturia—a shifting trend in pediatric urolithiasis? J Urol 188(4 suppl):1623–1627
Lande MB, Varade W, Erkan E, Niederbracht Y, Schwartz GJ (2005) Role of urinary supersaturation in the evaluationof children with urolithiasis. Pediatr Nephrol 20:491–494
Lopez M, Hoppe B (2010) History, epidemiology and regional diversities of urolithiasis. Pediatr Nephrol 25(1):49–59
Lotan Y (2009) Economics and cost of care of stone disease. Adv Chronic Kidney Dis 16:5–10
Matlaga BR, Schaeffer AJ, Novak TE, Trock BJ (2010) Epidemiologic insights into pediatric kidney stone disease. Urol Res 38(6):453–457
Milošević D, Batinić D, Blau N, Konjevoda P, Štambuk N, Votava-Raić A et al (1998) Determination of urine saturation with computer program Equil 2 as a method for estimation of the risk of urolithiasis. J Chem Inf Comput Sci 38(4):646–650
Milošević D, Batinić D, Konjevoda P, Blau N, Štambuk N, Lj N et al (2003) Analysis of calcium, oxalate, and citrate interaction in idiopathic calcium urolithiasis in children. J Chem Inf Comput Sci 43(6):1844–1847
Neuhaus TJ, Belzer T, Blqau N, Hoppe B, Sidhu H, Leumann E (2000) Urinary oxalate excretion in urolithiasis and nephrocalcinosis. Arch Dis Child 82:322–326
Novak TE, Lakshmanan Y, Trock BJ, Gearhart JP, Matlaga BR (2009) Sex prevalence of pediatric stone disease in the United States: an epidemiologic investigation. Urology 74(1):104–107
Passerotti C, Chow JS, Silva A, Schoettler CL, Rosoklija I, Perez-Rosello J et al (2009) Ultrasound versus computerized tomography for evaluating urolithiasis. J Urol 182(4 Suppl):1829–1834
Pietrow PK, Pope JC 4th, Adams MC, Shyr Y, Brock JW 3rd (2002) Clinical outcome of pediatric stone disease. J Urol 167:670–673
Sas DJ (2011) An update on the changing epidemiology and metabolic risk factors in pediatric kidney stone disease. Clin J Am Soc Nephrol 6(8):2062–2068
Scales CD Jr, Curtis LH, Norris RD, Springhart WP, Sur RL, Schulman KA et al (2007) Changing gender prevalence of stone disease. J Urol 177(3):979–982
Schissel BL, Johnson BK (2011) Renal stones: evolving epidemiology and management. Pediatr Emerg Care 27(7):676–681
Sharma AP, Filler G (2010) Epidemiology of pediatric urolithiasis. Indian J Urol 26(4):516–522
Siener R, Hesse A (1993) Einfluβ verschiedener kostformen auf die harnzusammen-setzung und das kalziumoxalat-steinbildungsrisiko. Z Ermährungswiss 32:46–65
Spivacow FR, Negri AL, del Valle EE, Calvino I, Fradinger E, Zanchetta JR (2008) Metabolic risk factors in children with kidney stone disease. Pediatr Nephrol 23:1129–1133
Sternberg K, Greenfield SP, Williot P, Wan J (2005) Pediatric stone disease: an evolving experience. J Urol 174:1711–1714
Strohmaier WL, Seilnacht J, Schubert G (2012) Urinary stone formers with hypocitraturia and “normal” urinary pH are at high risk for recurrence. Urol Int 88(3):294–297
Taylor EN, Stampfer MJ, Curhan CC (2004) Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J AM Soc Nephrol 15:3225–3232
Tefekli A, Esen T, Ziylan O, Erol B, Armagan A, Ander H, Akinet N (2000) Metabolic risk factors in pediatric and adult calcium oxalate urinary stone formers: is there any difference. Urol Int 459:1–10
Trinchieri A (2008) Epidemiology of urolythiasis: an update. Clin Cases Miner Bone Metab 5(2):101–106
VanDervoort K, Wiesen J, Frank R, Vento S, Crosby V, Chandra M, Trachtman H (2007) Urolithiasis in pediatric patients: a single center study of incidence, clinical presentation and outcome. J Urol 177:2300–2305
Werness P, Brown CM, Smith LH, Finlayson B (1985) EQUIL II: a BASIC computer program for the calculation of urinary saturation. J Urol 134:1242–124
Conflict of interest
We, the authors, declare that we do not received financial support from any organization for this article.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Milošević, D., Batinić, D., Turudić, D. et al. Demographic characteristics and metabolic risk factors in Croatian children with urolithiasis. Eur J Pediatr 173, 353–359 (2014). https://doi.org/10.1007/s00431-013-2165-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00431-013-2165-6