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Omalizumab in the treatment of eosinophilic esophagitis and food allergy

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Abstract

Omalizumab is currently used in severe asthma and has been tried in other allergic disorders. The authors report two patients with multiple food allergies and eosinophilic esophagitis on a very restrictive diet who have been treated with omalizumab, in order to improve food intolerance—the major distressing factor in their lives. The patients significantly improved in the reported symptoms. However, no improvement was seen regarding esophageal endoscopy and histology. Given the poor histological and endoscopy response, eosinophilic esophagitis persistence is unlikely to be IgE dependent. Omalizumab may improve the quality of life of patients with severe food allergy by improving symptoms, but it does not appear to change endoscopic and histological features of eosinophilic esophagitis in a short follow-up.

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Authors and Affiliations

  1. Department of Pediatrics, Hospital S. João, EPE, Alameda Prof. Hernâni Monteiro, 4200-319, Oporto, Portugal

    Ruben Rocha, Artur Bonito Vitor, Eunice Trindade, Rosa Lima, Marta Tavares & Jorge Amil Dias

  2. Department of Pathology, Hospital S. João, EPE, Oporto, Portugal

    Joanne Lopes

Authors
  1. Ruben Rocha
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  2. Artur Bonito Vitor
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  3. Eunice Trindade
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  4. Rosa Lima
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  5. Marta Tavares
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  6. Joanne Lopes
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  7. Jorge Amil Dias
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Corresponding author

Correspondence to Ruben Rocha.

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Rocha, R., Vitor, A.B., Trindade, E. et al. Omalizumab in the treatment of eosinophilic esophagitis and food allergy. Eur J Pediatr 170, 1471–1474 (2011). https://doi.org/10.1007/s00431-011-1540-4

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  • DOI: https://doi.org/10.1007/s00431-011-1540-4

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