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Cardiovascular impairment in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM)

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Abstract

Left ventricular (LV) function was assessed in 42 patients (mean age ± SD, 18.45 ± 3.76 years; 17 males) with type I diabetes mellitus (T1DM; mean duration 9.89 years) and in 43 healthy controls (mean age ± SD, 18.27 ± 3.36 years; 18 males). Systolic, diastolic cardiac function and LV dimensions were assessed using M-mode and Doppler echocardiography. Neural autonomic function was assessed by measuring RR variation during deep breathing, Valsava maneuver, 30/15 ratio, and blood pressure response to standing. Fractional shortening, peak velocity of early ventricular filling (E wave), peak velocity of LV filling (A wave), E/A ratio, deceleration time, isovolumic relaxation time, LV dimensions (interventricular septum, posterior wall thickness, end diastolic diameter [EDD] and systolic diameter [ESD]) were all comparable between patients with T1DM and controls. However, in 11 T1DM patients with microalbuminuria and/or retinopathy, EDD, ESD, E/A ratio, and E wave were all lower (p = 0.0011, p = 0.019, p = 0.0011, and p = 0.030, respectively) while, A wave, heart rate, and diastolic blood pressure were all higher (p = 0.008, p = 0.0024 and p = 0.004, respectively) compared to matched for age and sex controls. Furthermore, in six of the 11 T1DM patients with microangiopathy who had E/A <1.12 (<2 SD of the control mean), significant and marginally significant correlations were found between E/A ratio and the duration of the disease as well as the mean HbA1c of the last year (r = –0.38, p = 0.011 and r =  –0.287, p = 0.064, respectively). In conclusion, it has been found that impairment of diastolic, but not systolic, LV function can be detected early in young patients with T1DM and microangiopathy.

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Authors and Affiliations

  1. First Department of Pediatrics, “P & A Kyriakou” Children’s Hospital, Thivon & Levadias, 115 27, Athens, Greece

    A. Vazeou & A. Papadopoulou

  2. Cardiology Department, “P & A Kyriakou” Children’s Hospital, Athens, Greece

    D. Georgacopoulos

  3. Department of Biochemistry, “P & A Kyriakou” Children’s Hospital, Athens, Greece

    A. Drakatos

  4. Laiko Hospital, Athens, Greece

    M. Miha

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  1. A. Vazeou
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  2. A. Papadopoulou
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Correspondence to A. Vazeou.

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Vazeou, A., Papadopoulou, A., Miha, M. et al. Cardiovascular impairment in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM). Eur J Pediatr 167, 877–884 (2008). https://doi.org/10.1007/s00431-007-0603-z

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  • DOI: https://doi.org/10.1007/s00431-007-0603-z

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