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Serum lecithin:cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns

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Abstract

The aim of this study was to determine serum lecithin:cholesterol acyltransferase (LCAT) activity in parallel with HDL2 and HDL3 amounts and composition in pregnancy induced hypertension (PIH) and chronic hypertensive (CH) mothers and in their small for gestational age (SGA) newborns. LCAT activity was assayed by conversion of [3H] cholesterol to labelled cholesteryl ester. HDL2 and HDL3 were separated by ultracentrifugation. At term, cholesterol values were similar in PIH, CH and controls. However, higher levels of triglycerides were observed in PIH and CH (+20% and +21%, respectively) as compared with normotensive control mothers (NC). HDL2 and HDL3-phospholipids, HDL2-cholesterol concentrations and LCAT activity were lower in PIH and CH mothers than in NC mothers. Similar changes were also observed in SGA newborns of PHI mothers and in SGA newborns of CH mothers when compared to appropriate for gestational age newborns of control mothers (AGA-NC). In addition, SGA newborns showed low HDL2 and HDL3 apoA-I contents. Maternal hypertension and foetal intrauterine growth retardation are associated with profound abnormalities in HDL metabolism, consistent with an atherogenic risk. SGA lipoprotein profiles appear to implicate later metabolic diseases.

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Abbreviations

AGA:

appropriate for gestational age

Apo:

apolipoprotein

CH:

chronic hypertension

C/PL:

cholesterol to phospholipids ratio

HDL:

high density lipoproteins

HTA:

hypertension

LDL:

low density lipoproteins

LCAT:

lecithin:cholesterol acyltransferase

NC:

normotensive control

PIH:

pregnancy induced hypertension

PL:

phospholipids

SGA:

small for gestational age

SR-BI:

class B scavenger receptors type I

TC:

total cholesterol

TG:

triglycerides

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Acknowledgements

The authors are indebted to Anne Magnet, an English for specific purposes linguist at the University of Burgundy (France) for editing the manuscript. This work was supported by the International Research Extension grant 00 MDU 474 and a national organization of health research (ANDRS).

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Authors and Affiliations

  1. Laboratoire de Physiologie Animale et Biochimie,Faculté des Sciences, Université de Tlemcen, Tlemcen, Algeria

    B. Loukidi-Bouchenak & H. Merzouk

  2. Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d’Oran-Es-Sénia, Oran, Algeria

    M.Y. Lamri-Senhadji & M. Bouchenak

  3. Département de Physique, Faculté des Sciences, Université de Tlemcen, Tlemcen, Algeria

    S. Merzouk

  4. Service de Gynécologie Obstétrique, Centre Hospitalo-Universitaire, Tlemcen, Algeria

    B. Belarbi

  5. UPRES Lipides Nutrition EA 2422, Université de Bourgogne, 21000, Dijon, France

    J. Prost & J. Belleville

Authors
  1. B. Loukidi-Bouchenak
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  2. M.Y. Lamri-Senhadji
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  3. S. Merzouk
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  4. H. Merzouk
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  5. B. Belarbi
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  6. J. Prost
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  7. J. Belleville
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  8. M. Bouchenak
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Correspondence to H. Merzouk.

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Loukidi-Bouchenak, B., Lamri-Senhadji, M., Merzouk, S. et al. Serum lecithin:cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns. Eur J Pediatr 167, 525–532 (2008). https://doi.org/10.1007/s00431-007-0545-5

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  • DOI: https://doi.org/10.1007/s00431-007-0545-5

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