Skip to main content
Log in

A case of milk-protein-induced enterocolitis associated with enterotoxigenic E. coli and MRSA infections

  • Short Report
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Food protein-induced enterocolitis (FPIE) is a severe, cell-mediated gastrointestinal food hypersensitivity typically provoked by cow’s milk [Joint Task Force of AAAAI and ACAAI Food allergy: a practice parameter. XVII. Differential diagnosis of adverse reaction to foods. Ann Allergy Asthma Immunol 96(3 Suppl 2):S40–S44 (2006)]. We present an infant who developed FPIE associated with enterotoxigenic E. coli (ETEC) and methicillin-resistant Staphylococcus aureus (MRSA) infections. The case suggests that enteral infection may have a role in the development of sensitization to food protein and the pathogenesis of FPIE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abbreviations

FPIE:

food protein-induced enterocolitis

TNF-α:

tumor necrosis factor-α

ETEC:

enterotoxigenic E. coli

MRSA:

methicillin-resistant Staphylococcus aureus

PBMC:

peripheral blood mononuclear cells

References

  1. Fogg MI, Brown-Whitehorn TA, Pawlowski NA, Spergel JM (2006) Atopy patch test for the diagnosis of food protein-induced enterocolitis syndrome. Pediatr Allergy Immunol 17(5):351–355

    Article  PubMed  Google Scholar 

  2. Heyman M, Darmon N, Dupont C, Dugas B, Hirribaren A, Blaton MA, Desjeux JF (1994) Mononuclear cells from infants allergic to cow's milk secrete tumor necrosis factor alpha, altering intestinal function. Gastroenterology 106(6):1514–1523

    PubMed  CAS  Google Scholar 

  3. Joint Task Force of AAAAI and ACAAI (2006) Food allergy: a practice parameter. XVII. Differential diagnosis of adverse reaction to foods. Ann Allergy Asthma Immunol 96(3 Suppl 2):S40–S44

    Google Scholar 

  4. Madara JL, Stafford J (1989) Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 83(2):724–727

    Article  PubMed  CAS  Google Scholar 

  5. Plant A, Williams NA (2004) Modulation of the immune response by the cholera-like enterotoxins. Curr Top Med Chem 4(5):509–519

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yusei Ohshima.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Omata, N., Ohshima, Y., Yamada, A. et al. A case of milk-protein-induced enterocolitis associated with enterotoxigenic E. coli and MRSA infections. Eur J Pediatr 167, 683–684 (2008). https://doi.org/10.1007/s00431-007-0534-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00431-007-0534-8

Keywords

Navigation