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Intracranial aneurysm associated with chronic mucocutaneous candidiasis

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Abstract

Chronic mucocutaneous candidiasis (CMC) is a syndrome characterised by immune deficiency, often presenting familial dominant inheritance and association with autoimmune endocrinopathies. We report on a patient with CMC who died at 5 years of age of a brain haemorrhage following the rupture of a basilar-artery aneurysm. Candida hyphae in the basilar artery were found at autopsy. A common immunologic abnormality in CMC is the failure of patient’s T-lymphocytes to produce cytokines, which are essential for expression of cell-mediated immunity to Candida. Therefore, long-term treatment is mandatory.

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Authors and Affiliations

  1. Infectious Diseases Department, Giannina Gaslini Institute, University of Genoa, Largo Gerolamo Gaslini, 5-16147, Genoa, Italy

    M. G. Marazzi, E. Bondi & M. Strozzi

  2. Department of Paediatrics, G. Gaslini Institute, University of Genoa, Genoa, Italy

    A. Giannattasio

  3. Department of Pathology, G. Gaslini Institute, University of Genoa, Genoa, Italy

    C. Savioli

Authors
  1. M. G. Marazzi
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  2. E. Bondi
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  3. A. Giannattasio
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  4. M. Strozzi
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  5. C. Savioli
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Corresponding author

Correspondence to M. G. Marazzi.

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Marazzi, M.G., Bondi, E., Giannattasio, A. et al. Intracranial aneurysm associated with chronic mucocutaneous candidiasis. Eur J Pediatr 167, 461–463 (2008). https://doi.org/10.1007/s00431-007-0490-3

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  • DOI: https://doi.org/10.1007/s00431-007-0490-3

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