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Acute exacerbation of hepatitis in a boy with chronic HCV genotype-2 infection after a 9-year period of normal transaminases levels

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Abstract

We report on a boy with HCV genotype-2a infection who presented with a severe degree of ALTflare after 9 years of asymptomatic period and was treated with pegylated interferon and ribavirin. We suggest that children with HCV genotype-2 infection who show a significant ALT flare should be treated with anti-viral therapies in order to avoid progression of hepatic fibrosis.

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References

  1. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL, Häussinger D, Diago M, Carosi G, Dhumeaux D, Craxi A, Lin A, Hoffman J, Yu J (2002) Pegylated interferon alpha-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347:975–982

    Article  PubMed  CAS  Google Scholar 

  2. Hiraga N, Suzuki F, Akuta N, Suzuki Y, Sezaki H, Hosaka T, Someya T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Kobayashi M, Matsuda M, Watabiki S, Satoh J, Kumada H (2005) Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up. J Med Virol 75:240–248

    Article  PubMed  CAS  Google Scholar 

  3. Jonas MM (2002) Children with hepatitis C. Hepatology 36 (5 Suppl 1):S173–S178

    Article  PubMed  Google Scholar 

  4. Rumi MG, De Filippi F, Donato MF, Del Ninno E, Colombo M (2002) Progressive hepatic fibrosis in healthy carriers of hepatitis C virus with a transaminase breakthrough. J Viral Hepat 9:71–74

    Article  PubMed  CAS  Google Scholar 

  5. Tsuji K, Yamasaki K, Yamanishi M, Kawakami M, Shirahama S (2001) Risk of alanine aminotransferase flare-up among asymptomatic hepatitis C virus RNA carriers. A 10-year follow-up study. J Gastroenterol Hepatol 16:536–540

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Osaka General Medical Center, 3-1-56 Bandaihigashi, Sumiyoshi-ku, Osaka, 558-8558, Japan

    Hitoshi Tajiri & Yasuhiro Hasegawa

  2. Department of Pediatrics, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565–0871, Japan

    Yuri Etani, Sotaro Mushiake & Keiichi Ozono

Authors
  1. Hitoshi Tajiri
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  2. Yuri Etani
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  3. Sotaro Mushiake
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  4. Yasuhiro Hasegawa
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  5. Keiichi Ozono
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Corresponding author

Correspondence to Hitoshi Tajiri.

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Tajiri, H., Etani, Y., Mushiake, S. et al. Acute exacerbation of hepatitis in a boy with chronic HCV genotype-2 infection after a 9-year period of normal transaminases levels. Eur J Pediatr 166, 501–502 (2007). https://doi.org/10.1007/s00431-006-0267-0

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  • DOI: https://doi.org/10.1007/s00431-006-0267-0

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