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Pseudo-Bartter syndrome in a neonate on prostaglandin infusion

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Abstract

We describe a case of iatrogenic pseudo-Bartter syndrome caused by administration of prostaglandin E1 (PGE1 alprostadil). Although the use of i.v. PGE1 is a well-established pharmacological therapy in neonates with a ductus-dependent congenital cardiopathy to ensure ductus-dependent flow, we could only find one other report on pseudo-Bartter syndrome related to PGE1 infusion. Conclusion: primary Bartter syndrome is associated with endogenous increased levels of prostaglandins. Therefore, we postulate that the dose of prostaglandin E1 administered, immaturity and the genetic background are all relevant factors involved in the phenotypic presentation of iatrogenic pseudo-Bartter syndrome in this preterm infant.

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Fig. 1.

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Abbreviations

PDA:

patent ductus arteriosus

PG:

prostaglandin

PGE1:

prostaglandin E1

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Authors and Affiliations

  1. Neonatal Intensive Care Unit, Department of Paediatrics, University Hospitals Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium

    Sofie Vanhaesebrouck, Karel Allegaert, Christine Vanhole & Hugo Devlieger

  2. Paediatric Cardiology Unit, Department of Paediatrics, University Hospitals Gasthuisberg, Leuven, Belgium

    Marc Gewillig

  3. Paediatric Nephrology Unit, Department of Paediatrics, University Hospitals Gasthuisberg, Leuven, Belgium

    Willem Proesmans

Authors
  1. Sofie Vanhaesebrouck
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  2. Karel Allegaert
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  3. Christine Vanhole
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  4. Hugo Devlieger
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  5. Marc Gewillig
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  6. Willem Proesmans
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Corresponding author

Correspondence to Karel Allegaert.

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Vanhaesebrouck, S., Allegaert, K., Vanhole, C. et al. Pseudo-Bartter syndrome in a neonate on prostaglandin infusion. Eur J Pediatr 162, 569–571 (2003). https://doi.org/10.1007/s00431-003-1201-3

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  • DOI: https://doi.org/10.1007/s00431-003-1201-3

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