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High polymorphism rates in well-known T cell epitopes restricted by protective HLA alleles during HIV infection are associated with rapid disease progression in early-infected MSM in China

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Abstract

T cell epitopes restricted by several protective HLA alleles, such as B*57, B*5801, B*27, B*51 and B*13, have been very well defined over the past two decades. We investigated 32 well-known T cell epitopes restricted by protective HLA molecules among 54 Chinese men who have sex with men (MSM) at the early stage of HIV-1 infection. Subjects in our cohort carrying protective HLA types did not exhibit slow CD4 T cell count decline (P = 0.489) or low viral load set points (P = 0.500). Variations occurred in 96.88% (31/32) of the known wild-type epitopes (rate 1.85–100%), and the variation rates of the strains of two CRF01_AE lineages were significantly higher than those of non-CRF01_AE strains (76.82% vs. 48.96%, P = 0.004; 71.27% vs. 8.96%, P = 0.025). Subjects infected with CRF01_AE exhibited relatively rapid disease progression (P = 0.035). Therefore, the lack of wild-type protective T cell epitopes restricted by classic protective HLA alleles in CRF01_AE HIV-1 strains may be one of the reasons why rapid disease progression is observed in Chinese MSM with HIV-1 infection.

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Abbreviations

HIV-1:

Human immunodeficiency virus type 1

HLA:

Human leukocyte antigen

MSM:

Men who have sex with men

ELISA:

Enzyme-linked immunosorbent assay

VL:

Viral load

PCR-SSP:

Polymerase chain reaction sequence-specific primer

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Funding

This work was supported by mega projects of national science research for the 13th Five-Year Plan (2017ZX10201101), “Innovation Team Development Program 2016 (IRT_16R70)” of The Ministry of Education, and Natural Science Foundations (81871637,81371787,81701985).

Author information

Author notes

  1. Chuan He and Xiaoxu Han contributed equally to this work.

Authors and Affiliations

  1. NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, No 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China

    Chuan He, Xiaoxu Han, Hui Zhang, Fanming Jiang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang & Hong Shang

  2. Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China

    Chuan He, Xiaoxu Han, Hui Zhang, Fanming Jiang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang & Hong Shang

  3. Key Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, 110001, China

    Chuan He, Xiaoxu Han, Hui Zhang, Fanming Jiang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang & Hong Shang

  4. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Street, Hangzhou, 310003, China

    Chuan He, Xiaoxu Han, Hui Zhang, Fanming Jiang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang & Hong Shang

  5. Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, Oxford University, Oxford, UK

    Tao Dong

  6. Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK

    Tao Dong

Authors
  1. Chuan He
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  2. Xiaoxu Han
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  3. Hui Zhang
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  4. Fanming Jiang
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  5. Minghui An
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  6. Bin Zhao
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  7. Haibo Ding
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  8. Zining Zhang
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  9. Tao Dong
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  10. Hong Shang
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Corresponding author

Correspondence to Hong Shang.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of Medical Research Ethics Committee of the First Affiliated Hospital of China Medical University.

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All subjects provided informed consent for this study.

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He, C., Han, X., Zhang, H. et al. High polymorphism rates in well-known T cell epitopes restricted by protective HLA alleles during HIV infection are associated with rapid disease progression in early-infected MSM in China. Med Microbiol Immunol 208, 239–251 (2019). https://doi.org/10.1007/s00430-019-00585-x

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  • DOI: https://doi.org/10.1007/s00430-019-00585-x

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