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Malaria and human red blood cells

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Abstract

Invasion by the malaria parasite, Plasmodium falciparum, brings about extensive changes in the host red cells. These include loss of the normal discoid shape, increased rigidity of the membrane, elevated permeability to a wide variety of ionic and other species and increased adhesiveness, most notably to endothelial surfaces. These effects facilitate survival of the parasite within the host cell and tend to increase the virulence of disease that includes cerebral malaria and anemia. Numerous proteins secreted by the internalized parasite and interacting with red cell membrane proteins are responsible for the changes occurring to the host cell. Anemia, a serious clinical manifestation of malaria, is due to increased destruction of both infected and uninfected red cells due to membrane alterations, as well as ineffective erythropoiesis. There is very good evidence that various red cell disorders including hemoglobinopathies and hereditary ovalocytosis decrease the virulence of disease following parasite infection. A number of mechanism(s) are likely responsible for the protective effect of various red cell abnormalities including decreased invasion, impaired intraerythrocytic development of the parasites and altered interaction between exported parasite proteins and the red cell membrane skeleton.

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Acknowledgments

We would like to thank our colleagues and long-time collaborators, Ross Coppel and Kasturi Haldar, for teaching us about malaria and for their sustained and productive collaborative efforts with us over many years.

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Authors and Affiliations

  1. Red Cell Physiology Laboratory, New York Blood Center, 310 East 67th Street, New York, NY, 10065, USA

    Narla Mohandas

  2. Membrane Biology Laboratory, New York Blood Center, New York, NY, 10065, USA

    Xiuli An

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  1. Narla Mohandas
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  2. Xiuli An
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Correspondence to Narla Mohandas.

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Mohandas, N., An, X. Malaria and human red blood cells. Med Microbiol Immunol 201, 593–598 (2012). https://doi.org/10.1007/s00430-012-0272-z

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  • DOI: https://doi.org/10.1007/s00430-012-0272-z

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