Abstract
Intranuclear inclusions typical of cytomegalovirus infections were first noticed in 1881 by German scientists who thought they represented protozoa. After viruses were grown in cell cultures, Weller, Smith and Rowe independently isolated and grew CMV from man and mice in 1956–1957. Antibodies in 30–100% of normal adults indicate not only a past infection, but the presence of a present latent infection. The presence of CMV DNA in tissues and most organs surveyed indicates the ubiquity of latent infection. CMV disease requires the virus and some deficiency of immunity such as occurs in the immature fetus, in AIDS, and in transplant patients on immunosuppressive drugs. Antiviral agents can inhibit CMV replication but they cannot prevent or cure latent infections. A pharmacological approach using the many leads in understanding latency is needed.
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Ribbert H (1904) Ueber protozoenartige Zellen in der Niere eines syphilitischen Neugeborenen und in der Parotis von Kindern. Zbl All Pathol 15:945–948
Jesionek A, Kiolemenoglou B (1904) Ueber einen Befund von protozoenartigen Gebilden in den Organen eines hereditar-luetischen Foetus. Muenchner Med Wochenschr 51:1905–1907
Lòwenstein C (1907) Ueber protozoenartige Gebilde in den Organen von Kindern. Zbl Allg Pathol 18:513–718
Von Glahn WC, Pappenheimer AM (1925) Intranuclear inclusions in visceral disease. Am J Pathol 1:445–465
Lipschuetz B (1921) Untersuchungen ueber die Aetiologie der Krankheiten der Herpes genitalis. Arch Dermatol Syph 136:428–482
Farber S, Wolbach S (1932) Intranuclear and cytoplasmic inclusions (protozoan-like bodies) in the salivary glands and other organs of children. Am J Pathol 8:123–135
Wyatt JP, Saxton J, Lee RS, Pinkerton H (1950) Generalized cytomegalic inclusion disease. J Pediatr 36:271–294
Fetterman GH (1952) A new laboratory aid in the diagnosis of inclusion disease of infancy. Clin Pathol 22:424–425
Minder WH (1953) Die Aetiologie der Cytomegalia infantum. Schweiz Med Wochenschr 83:1180–1182
Enders JF, Weller TH, Robbins FC (1949) Cultivation of the lansing strain of poliomyelitis virus in cultures of various human embryonic tissues. Science 109:85–87
Weller TH, Macauley JC, Craig JM, Wirth P (1957) Isolation of intranuclear inclusion producing agents from infants with illnesses resembling cytomegalic inclusion disease. Proc Soc Exp Biol Med 94:4–12
Smith MG (1956) Propagation in tissue cultures of a cytopathogenic virus from human salivary gland virus (SVG) disease. Proc Soc Exp Biol Med 92:424–430
Rowe WP, Hartley JW, Waterman S et al (1956) Cytopathogenic agent resembling human salivary gland virus recovered from tissue cultures of human adenoids. Pro Soc Exp Biol Med 92:418–424
Weller TH (1953) Serial propagation in vitro of agents producing inclusion bodies derived from varicella and herpes zoster. Proc Soc Exp Biol Med 83:340–346
Weller TH (1970) Cytomegalovirus: the difficult years. J Infect Dis 122:532–539
Weller TH, Hanshaw JB, Scott DE (1960) Serologic differentiation of viruses responsible for cytomegalic inclusion disease. Virology 108:843–868
Boppana SB, Rivera LB, Fowler KB et al (2001) Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med 344:1366–1371
Arvin AM, Fast P, Myers M, Plotkin S, Rabinovich R (2004) Vaccine development to prevent cytomegalovirus disease: report from the National Vaccine Advisory Committee. Clin Infect Dis 39:233–239
Cha TA, Tom E, Kemble GW et al (1996) Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. J Virol 70:78–83
Krech U, Jung M, Jung F (1971) CMV infections in man. S. Karger, Basel, 124 pp
Reynolds DW, Stagno S, Hosty TS et al (1973) Maternal cytomegalovirus excretion and perinatal infection. N Engl J Med 289:1–5
Stagno S, Reynolds DW, Pass RF, Alford CA Jr (1980) Breast milk and the risk of cytomegalovirus infection. N Engl J Med 302:1073–1074
Numazaki Y, Yano N, Morizuka T et al (1970) Primary infection with human cytomegalovirus: virus isolation from healthy infants and pregnant women. Am J Epidemiol 91:410–417
Lamb SB, Stern H (1966) Cytomegalovirus mononucleosis with jaundice as presenting sign. Lancet 2:1003–1007
Chretien JH, McGinnis CG, Muller A (1977) Venereal causes of cytomegalovirus mononucleosis. JAMA 238:1644–1645
Handsfield HH, Chandler SH, Caine VA et al (1985) Cytomegalovirus infection in sex partners: evidence of transmission. J Infect Dis 151:344–348
Drew WL, Sweet ES, Miner RC et al (1984) Multiple infections by cytomegalovirus in patients with acquired immune deficiency syndrome: documentation by southern blot hybridization. J infect Dis 155:891–896
Coutinho RA, Van Dillen PW, Van Lent PA et al (1984) Infection with cytomegalovirus in homosexual men. Br J Vener Dis 60:249–252
Collier AC, Meyers JD, Corey L et al (1987) Cytomegalovirus infection in homosexual men. Am J Med 82:593–600
Mintz L, Drew WL, Miner RC, Braff EH et al (1983) Cytomegalovirus infections in homosexual men. Ann Intern Med 99:326–329
Reddehase MJ (2006) Cytomegaloviruses: molecular biology and immunology, Caister Academic Press, Norfolk, 619 pp
Ho M, Suwansirikul S, Dowling JN et al (1975) The transplanted kidney as a source of cytomegalovirus infection. New Engl J Med 293:1109–1112
Ho M (1991) Cytomegalovirus: biology and infection, 2nd edn, Chap 13. Plenum, New York, pp 249–300
Hendrix RM, Wagenaar M, Slobbe RL, Bruggeman CA (1997) Widespread presence of cytomegalovirus DNA in tissues of healthy trauma victims. J Clin Pathol 50:59–63
Sinclair J, Sissons P (1996) Latent and persistent infections of monocytes and macrophages. Intervirology 39:293–301
Pereira L, Maidji E, McDonagh S, Tabata T (2006) Routes of human CMV transmission and infection at the uterine-placental interface. In: Reddehase MJ (ed) Cytomegaloviruses: molecular biology and immunology, Chap 3. Caister Academic Press, Norfolk, pp 29–48
Klemola E, Kaariainen L (1965) Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis. Br Med J 2:1099–1102
Rinaldo CR, Levin MJ, Carney WP et al (1979) Interaction of lymphocytes with cytomegalovirus. In: Proffit MR (ed) Virus-lymphocyte interactions: implications for disease. Elsevier-North Holland, Amsterdam, pp 267–282
Saltzman RL, Quirk MR, Jordan MC (1988) Disseminated cytomegalovirus infecton. Molecular ananlysis of virus and leukocyte interactions in viremia. J Clin Invest 81:75–81
Diosi P, Moldovan E, Tomescu N (1969) Latent cytomegalovirus infection in blood donors. Br Med J 4:660–662
Armstrong JA, Tarr GC, Ho M et al (1976) Cytomegalovirus infection with in children undergoing open-heart surgery. Yale J Biol Med 49:83–91
Ho M (1991) Cytomegalovirus: biology and infection, 2nd edn. Plenum, New York, p 177, 440 pp
Yeager AS, Grumet FC, Hafleigh EB et al (1981) Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr 98:281–287
Bowden RA, Sayers M, Flournoy N et al (1986) Cytomegalovirus immune globulin and seronegative blood products to prevent primary cytomegalovirus infection after marrow transplantation. N Engl J Med 314:1006–1010
Demmler GJ (1991) Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis 13:315–329
Gallant JE, Moore RD, Richman DD et al (1992) Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. J Infect Dis 166:1223–1227
Verbraak FD, Boom R, Wertheim-van Dillen PM et al (1999) Influence of highly active antiretroviral therapy (HAART) on the development of CMV disease in HIV positive patients at high risk for CMV disease. Br J Ophthalmol 83:1186–1189
Cohen BA, McArthur JC, Grohman S et al (1993) Neurologic prognosis of cytomegalovirus polyradiculomyelopathy in AIDS. Neurology 43:493–499
Holland NR, Power C, Mathews VP et al (1994) Cytomegalovirus encephalitis in acquired immunodeficiency syndrome (AIDS). Neurology 44:507–514
Haymaker W, Girdany BR, Stephens J et al (1954) Cerebral involvement with advanced periventricular calcification in generalized cytomegalic inclusion disease in the newborn. J Neuropathol Exp Neurol 13:562–586
Price TA, Digioia RA, Simon GL (1992) Ganciclovir treatment of cytomegalovirus ventriculitis in a patient infected with human immunodeficiency virus. Clin Infect Dis 15:606–608
Bartlett JG, Laughon B, Quinn TC (1988) Gastrointestinal complications of AIDS. In: DeVita VT, Hellman S, Rosenberg SA (eds) AIDS, etiology, diagnosis, treatment and prevention, 2nd edn. Lippincott, Philadelphia, pp 227–244
Pereyra F, Rubin RH (2004) Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients. Curr Opin Infect Dis 17:357–361
Ho M (1991) Cytomegalovirus: biology and infection, 2nd edn. Plenum, New York, p 250, 440 pp
Ho M (1991) Cytomegalovirus: biology and infection, 2nd edn. Plenum, New York, p 251, 440 pp
Ho M (1991) Cytomegalovirus: biology and infection, 2nd edn. Plenum, New York, p 257, 440 pp
Meyers JD, Flournoy N, Thomas ED (1986) Risk factors for cytomegalovirus infection after human marrow transplant. J Infect Dis 153:478–488
Peterson PK, Balfour HH, Marker SC et al (1980) Cytomegalovirus disease in renal allograft recipients: a prospective study of the clinical features, risk factors and impact on renal transplantation. Medicine 59:283–300
Ho M (1987) Infection and organ transplantation. In: Gelman S (ed) Anesthesia and organ transplantation. WB Saunders, Philadelphia, pp 49–60
Dummer JS, Montero CG, Griffith BP et al (1986) Infection in heart-lung transplant recipients. Transplantation 41:725–729
Rubin RH, Tolkoff-Rubin NE, Oliver D et al (1985) Multicenter seroepidemiologic study of the impact of cytomegalovirus infection on renal transplantation. Transplantation 40:243–249
Chou S, Norman DJ (1985) Effect of OKT3 antibody therapy on cytomegalovirus reactivation in renal transplant recipients. Transplantation Proc 17:2755–2756
Starzl TE, Fung J, Venkataramman R et al (1989) FK 506 for liver, kidney, and pancreas transplantation. Lancet 2:1000–1004
Thomason AW (1990) FK-506-how much potential? Immunol Today 11:6–9
Spector SA, Davis JL, Singh N (2006) Cytomegalovirus. http://www.antimicrobe.org/12rev.asp
Cheng YC, Huang ES, Lin JC et al (1983) Unique spectrum of activity of 9-[(1,3-dihydro-2-propoxy)methyl]guanine against herpes simplex type 1. Proc Natl Acad USA 80:2767–2770
Felsenstein D, D’Amico DJ, Hirsch MS et al (1985) Treatment of cytomegalovirus retinitis with 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine. Ann Intern Med 103:377–380
Felsenstein D, D’Amico DJ, Hirsch MS et al (1985) Treastment of cytomegalovirus retinitis with 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine and high-dose corticosteroids. Ann Intern Med 105:214–215
Bach MC, Bagwell SP, Knapp NP et al (1985) 9-(1,3dihydroxy-2-propoxymethyl)guanine for cytomegalovirus infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med 103:381–384
Reed EC, Bowden RA, Dandliker PS et al (1988) Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants. Ann Intern Med 109:783–78
Lazzarotto T, Dal Monte P, Landini MP (1996) Recent advances in the diagnosis of cytomegalovirus infection. Ann Biol Clin 54:259–265
Spector SA, Merrill R, Wolf D et al (1992) Detection of human cytomegalovirus in plasma of AIDS patients during acute visceral disease by DNA amplification. J Clin Microbiol 30:2359–2365
Paya CV (2001) Prevention of cytomegalovirus disease in recipients of solid organ transplants. Clin Infect Dis 32:596–603
Singh N (2005) Late-onset cytomegalovirus disease as a significant complication in organ transplant recipients receiving antiviral prophylaxis: a call to heed mounting evidence. Clin Infect Dis 40:704–708
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Ho, M. The history of cytomegalovirus and its diseases. Med Microbiol Immunol 197, 65–73 (2008). https://doi.org/10.1007/s00430-007-0066-x
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DOI: https://doi.org/10.1007/s00430-007-0066-x