Abstract
We studied the thalamic afferents to cortical areas in the precuneus using injections of retrograde fluorescent neuronal tracers in four male macaques (Macaca fascicularis). Six injections were within the limits of cytoarchitectural area PGm, one in area 31 and one in area PEci. Precuneate areas shared strong input from the posterior thalamus (lateral posterior nucleus and pulvinar complex) and moderate input from the medial, lateral, and intralaminar thalamic regions. Area PGm received strong connections from the subdivisions of the pulvinar linked to association and visual function (the medial and lateral nuclei), whereas areas 31 and PEci received afferents from the oral division of the pulvinar. All three cytoarchitectural areas also received input from subdivisions of the lateral thalamus linked to motor function (ventral lateral and ventral anterior nuclei), with area PEci receiving additional input from a subdivision linked to somatosensory function (ventral posterior lateral nucleus). Finally, only PGm received substantial limbic association afferents, mainly via the lateral dorsal nucleus. These results indicate that area PGm integrates information from visual association, motor and limbic regions of the thalamus, in line with a hypothesized role in spatial cognition, including navigation. By comparison, dorsal precuneate areas (31 and PEci) are more involved in sensorimotor functions, being akin to adjacent areas of the dorsal parietal cortex.
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Abbreviations
- AD:
-
Anterior Dorsal
- AM:
-
Anterior Medial
- AV:
-
Anterior Ventral
- LD:
-
Lateral Dorsal
- MD:
-
Medial Dorsal
- MDdc:
-
Medial Dorsal, densocellular part
- MDmc:
-
Medial Dorsal, magnocellular part
- MDmc/pc:
-
Medial Dorsal, magnocellular/parvocellular part
- MDmf:
-
Medial Dorsal, multiform part
- MDpc:
-
Medial Dorsal, parvocellular part
- VA:
-
Ventral Anterior
- VAdc:
-
Ventral Anterior, densocellular part
- VAmc:
-
Ventral Anterior, magnocellular part
- VApc/dc:
-
Ventral Anterior, parvocellular/densocellular part
- VL:
-
Ventral Lateral
- VLc:
-
Ventral Lateral, caudal
- VLm:
-
Ventral Lateral, medial
- VLo:
-
Ventral Lateral, oral
- VLps:
-
Ventral Lateral, postrema
- VPI:
-
Ventral Posterior Inferior
- VPL:
-
Ventral Posterior Lateral
- VPLc:
-
Ventral Posterior Lateral, caudal
- VPLo:
-
Ventral Posterior Lateral, oral
- VPM:
-
Ventral Posterior Medial
- VPMpc:
-
Ventral Posterior Medial, parvocellular
- X:
-
Area X
- CL:
-
Central Lateral
- CM:
-
Centromedian
- Csl:
-
Central superior lateral
- Li:
-
Limitans
- Pcn:
-
Paracentral
- PF:
-
Parafascicular
- SG:
-
Suprageniculate
- Cdc:
-
Central densocellular
- Cif:
-
Central inferior
- Cim:
-
Central intermediate
- Clc:
-
Central latocellular
- Cs:
-
Central superior
- Pa:
-
Paraventricular
- Pt:
-
Paratenial
- Re:
-
Reuniens
- LP:
-
Lateral Posterior
- Pul:
-
Pulvinar
- Pul.i:
-
Pulvinar, inferior subdivision
- Pul.l:
-
Pulvinar, lateral subdivision
- Pul.m:
-
Pulvinar, medial subdivision
- Pul.o:
-
Pulvinar, oral (anterior) subdivision
- GLd:
-
Lateral geniculate body, dorsal division
- GMmc:
-
Medial geniculate body, magnocellular division
- GMpc:
-
Medial geniculate body, parvocellular division
- Hlpc:
-
Lateral habenula, parvocellular division
- Hm:
-
Medial habenula
- R:
-
Reticular
- Sm:
-
Stria medullaris
- STN:
-
Subthalamic nucleus
- THI:
-
Habenulo-interpendicular tract
- SPL:
-
Superior parietal lobule
- dr PGm:
-
Area PGm, dorsorostral sector
- vc PGm:
-
Area PGm, ventrocaudal sector
- V6:
-
Area V6
- V6Ad:
-
Area V6A, dorsal portion
- V6Av:
-
Area V6A, ventral portion
- PEc:
-
Area PEc
- PE:
-
Area PE
- PEci:
-
Area PE, cingulate portion
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Acknowledgements
We thank K. E. Richardson, M. Verdosci, and F. Campisi for expert technical assistance and C. Cranfield for proofreading the manuscript.
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Australian Research Council (CE140100007, DE120102883, DP140101968), National Health and Medical Research Council (1020839, 1082144), European Union Grant FP7-ICT 217077-EYESHOTS, FP7-PEOPLE-2011-IOF 300452 (S.B.), H2020-MSCA-734227-PLATYPUS and Ministero dell’Università e della Ricerca (2015AWSW2Y_001, 2017KZNZLN), and Fondazione del Monte di Bologna e Ravenna, Italy.
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Gamberini, M., Passarelli, L., Impieri, D. et al. Thalamic afferents emphasize the different functions of macaque precuneate areas. Brain Struct Funct 225, 853–870 (2020). https://doi.org/10.1007/s00429-020-02045-2
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DOI: https://doi.org/10.1007/s00429-020-02045-2