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Population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space

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Abstract

Animal models of the rhesus macaque (Macaca mulatta), the most widely used nonhuman primate, have been irreplaceable in neurobiological studies. However, a population-averaged macaque brain diffusion tensor imaging (DTI) atlas, including comprehensive gray and white matter labeling as well as bony and facial landmarks guiding invasive experimental procedures, is not available. The macaque white matter tract pathways and microstructures have been rarely recorded. Here, we established a population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space incorporating bony and facial landmarks, and delineated microstructures and three-dimensional pathways of major white matter tracts in vivo MRI/DTI and ex vivo (postmortem) DTI of ten rhesus macaque brains were acquired. Single-subject macaque brain DTI template was obtained by transforming the postmortem high-resolution DTI data into in vivo space. Ex vivo DTI of ten macaque brains was then averaged in the in vivo single-subject template space to generate population-averaged macaque brain DTI atlas. The white matter tracts were traced with DTI-based tractography. One hundred and eighteen neural structures including all cortical gyri, white matter tracts and subcortical nuclei, were labeled manually on population-averaged DTI-derived maps. The in vivo microstructural metrics of fractional anisotropy, axial, radial and mean diffusivity of the traced white matter tracts were measured. Population-averaged digital atlas integrated into in vivo space can be used to label the experimental macaque brain automatically. Bony and facial landmarks will be available for guiding invasive procedures. The DTI metric measurements offer unique insights into heterogeneous microstructural profiles of different white matter tracts.

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Acknowledgements

This study was supported by NIH Grants R21 EB009545(HH), R01MH092535(HH), U01MH105972(NS) and U54 HD086984(HH).

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Authors and Affiliations

  1. Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, China

    Lei Feng, Qiaowen Yu & Shuwei Liu

  2. Radiology Research, Children’s Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

    Lei Feng, Tina Jeon, Minhui Ouyang, Qinmu Peng & Hao Huang

  3. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Tina Jeon, Qiaowen Yu, Minhui Ouyang, Virendra Mishra & Hao Huang

  4. Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA

    Mihovil Pletikos & Nenad Sestan

  5. Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA

    Michael I. Miller

  6. Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA

    Susumu Mori

  7. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA

    Susumu Mori

  8. Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA

    Steven Hsiao

  9. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

    Hao Huang

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  1. Lei Feng
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  2. Tina Jeon
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  3. Qiaowen Yu
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  4. Minhui Ouyang
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  6. Virendra Mishra
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  7. Mihovil Pletikos
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  8. Nenad Sestan
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  9. Michael I. Miller
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  10. Susumu Mori
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  11. Steven Hsiao
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  12. Shuwei Liu
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  13. Hao Huang
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Correspondence to Hao Huang.

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Feng, L., Jeon, T., Yu, Q. et al. Population-averaged macaque brain atlas with high-resolution ex vivo DTI integrated into in vivo space. Brain Struct Funct 222, 4131–4147 (2017). https://doi.org/10.1007/s00429-017-1463-6

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  • DOI: https://doi.org/10.1007/s00429-017-1463-6

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