Abstract
The maturation of cortical inhibition provided by parvalbumin-containing basket cells derived from the medial ganglionic eminence (MGE) is a key event in starting the enhanced visual cortical plasticity during the critical period. Although it is generally assumed that a further increase in inhibition closes the critical period again, it was recently shown that embryonic interneurons derived from the MGE can induce an additional, artificial critical period when injected into the visual cortex of young mice. It has, however, remained open whether this effect was indeed specific for MGE-derived cells, and whether critical period-like plasticity could also be induced in fully adult animals. To clarify these issues, we injected explants from either the MGE or the caudal ganglionic eminence (CGE) into the visual cortices of fully adult mice, and performed monocular deprivation 33 days later for 4 days. Animals implanted with MGE cells, but not with CGE cells, showed marked ocular dominance plasticity. Immunohistochemistry confirmed that the injected cells from both sources migrated far in the host cortex, that most developed into neurons producing GABA, and that only cells from the MGE expressed parvalbumin. Thus, our results confirm that the plasticity-inducing effect of embryonic interneurons is specific for cells from the MGE, and is independent of the host animal’s age.
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Acknowledgments
We are grateful to Vanessa Knölker for help with data analysis, Elisabeth Meier for excellent technical assistance, and to Sandra Clemens for animal care. We further wish to thank Prof. Christian Hübner and Dr. Lutz Liebmann (Institute for Human Genetics, Jena) for their willingness to cooperate, and Dr. Annika Döding for proof-reading the manuscript.
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J. Bolz and K. Lehmann contributed equally.
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Isstas, M., Teichert, M., Bolz, J. et al. Embryonic interneurons from the medial, but not the caudal ganglionic eminence trigger ocular dominance plasticity in adult mice. Brain Struct Funct 222, 539–547 (2017). https://doi.org/10.1007/s00429-016-1232-y
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DOI: https://doi.org/10.1007/s00429-016-1232-y