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Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults

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Abstract

Overweight and obesity are rapidly becoming a central public health challenge around the world. Previous studies have suggested that elevated Body Mass Index (BMI) might be associated with structural changes in both gray and white matter, but this association is still not well understood. The present study aimed to investigate the relationship between BMI and brain structure with a relatively large sample of young adults (N = 336) in a small age range (20 ± 1 years). Voxel-based morphometry results showed significant negative correlations between BMI and gray-matter volumes in the midcingulate cortex (MCC), left orbital frontal cortex, and left ventromedial prefrontal cortex. There was also a significant negative correlation between BMI and white matter integrity as indexed by fractional anisotropy in bilateral cingulum. Further tractography analysis showed a significant negative correlation between BMI and the number of fibers passing the MCC region. Regression analysis showed that gray matter and white matter in these regions both contributed to the variance of BMI. These results remained significant even when analysis was restricted to the subjects with normal weights. Finally, we found that decision-making ability (as assessed by the Iowa Gambling Task) mediated the association between the structure of the MCC (a region responsible for impulse control and decision making) and BMI. These results shed light on the structural neural basis of weight variations.

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Acknowledgments

This research was supported by the 111 Project (B07008) to Qi Dong, the National Science Foundation of China (31130025) to Gui Xue, and by research grants from NIDA R01DA023051 and NCI R01CA152062 to Antoine Bechara. We would also like to thank all lab members who helped with data collection.

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Authors and Affiliations

  1. Faculty of Psychology, Southwest University (SWU), Beibei, Chongqing, 400715, China

    Qinghua He

  2. National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China

    Qinghua He, Qi Dong, Gui Xue & Chunhui Chen

  3. Brain and Creativity Institute, University of Southern California, Los Angeles, CA, 90089, USA

    Qinghua He & Antoine Bechara

  4. Department of Psychology and Social Behavior, University of California, Irvine, Irvine, CA, 92697, USA

    Chuansheng Chen

  5. Center for Cognitive and Behavioral Brain Imaging, The Ohio State University, Columbus, OH, 43210, USA

    Zhong-Lin Lu

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  1. Qinghua He
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He, Q., Chen, C., Dong, Q. et al. Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults. Brain Struct Funct 220, 319–329 (2015). https://doi.org/10.1007/s00429-013-0657-9

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