Ki-ras
mutations by denaturing gradient gel electrophoresis (DGGE) and direct sequencing after microdissection. Point mutations at codon 12 were found in 7 of 20 tumours of low malignant potential (LMP) (35%) and in 2 of 6 well-differentiated carcinomas (33%). In contrast, no mutations were detected in the 11 poorly differentiated ovarian carcinoma samples or in the 7 serous cystadenomas. The frequency of Ki-ras mutations in serous ovarian tumours seems to correlate with the malignant potential of the neoplasms. The data favour the hypothesis of a de novo development of poorly differentiated ovarian carcinomas and do not support an evolution from LMP tumours or well-differentiated carcinomas.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 8 June 1998/Accepted: 8 October 1998
Rights and permissions
About this article
Cite this article
Haas, C., Diebold, J., Hirschmann, A. et al. In serous ovarian neoplasms the frequency of Ki-ras mutations correlates with their malignant potential. Virchows Archiv 434, 117–120 (1999). https://doi.org/10.1007/s004280050314
Issue Date:
DOI: https://doi.org/10.1007/s004280050314