Abstract
In a retrospective analysis of 142 medullary thyroid carcinomas, four sporadic cases with an unusual histological and immunohistochemical appearance were found. Three cases (two males, one female) had very few calcitonin-positive tumour cells, while the fourth case (male) completely lacked calcitonin immunoreactivity at both mRNA and protein levels, whereas a variety of neuroendocrine markers were positive in at least 50% of tumour cells. The four tumours were completely devoid of carcinoembryonic antigen expression and of amyloid. Differential diagnosis and histogenetic considerations are discussed.
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Received: 20 February 1998 / Accepted: 23 May 1998
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Schmid, K., Ensinger, C. ”Atypical” medullary thyroid carcinoma with little or no calcitonin expression. Virchows Archiv 433, 209–215 (1998). https://doi.org/10.1007/s004280050238
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DOI: https://doi.org/10.1007/s004280050238