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Development of head and neck pathology in Europe

  • Review and Perspectives
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Abstract

This review gives a brief history of the development of head and neck pathology in Europe from a humble beginning in the 1930s to the explosive activities the last 15 years. During the decades before the introduction of immunohistochemistry in the 1980s, head and neck pathology grew as a subspeciality in many European countries. In the late 1940s, the Institute of Laryngology and Otology with its own pathology laboratory was founded in London, and in 1964 the World Health Organization (WHO) International Reference Centre for the Histological Classification of Salivary Tumours was established at the Bland-Sutton Institute of Pathology, also in London. International collaboration, and very much so in Europe, led to the publication of the first WHO Classification of Salivary Gland Tumours in 1972. In the 1960s, a salivary gland register was organised in Hamburg and in Cologne the microlaryngoscopy was invented enabling microscopic endoscopic examination and rather shortly afterwards a carbon dioxide laser attached to the microscope became established and laryngeal lesions could be treated by laser vaporisation. During the last three decades, the use of immunohistochemistry supplemented with cytogenetic and refined molecular techniques has greatly facilitated the pathological diagnostics of head and neck lesions and has had a huge impact on research. Collaboration between different European centres has drastically increased partly due to establishment of scientific societies such as the Head and Neck Working Group (HNWG) within the European Society of Pathology and the International Head and Neck Scientific Group (IHNSG). A very large number of European pathologists have contributed to the 2nd, 3rd and 4th WHO books, and are involved in the upcoming 5th edition. Accredited educational meetings and courses are nowadays regularly arranged in Europe. Numerous textbooks on head and neck pathology have been written and edited by European pathologists. The increased collaboration has created larger series of tumours for research and new entities, mainly defined by their genetic abnormalities, are continuously emerging from Europe, particularly regarding salivary gland neoplasms and “undifferentiated” sinonasal tumours. These findings have led to a better and more precise classification and open the possibilities for new treatment strategies.

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References

  1. Batsakis JG (1974) Tumors of the head and neck. Clinical and pathological considerations. Williams & Wilkins, Baltimore.

  2. Batsakis JG (1979) Tumors of the head and neck. Clinical and pathological considerations. 2nd edn., Williams & Wilkins, Baltimore.

  3. Rosai J (2011) Rosai and Ackerman’s surgical pathology, 10th edn. Elsevier Inc., Edinburgh

    Google Scholar 

  4. Eggston A, Wolff D (1947) Histopathology of the ear, nose and throat. Williams & Wilkins, Baltimore

    Google Scholar 

  5. Foote FW Jr, Frazell EL (1954) Tumors of the major salivary glands. Atlas of tumor pathology, 1st series, Section IV, Fascicle II. Armed Forces Institute of Pathology, Washington, DC.

  6. Ash JE, Raum M (1956) An atlas of otolaryngologic pathology. American Academy of Ophthalmology and Otolaryngology. The American Registry of Pathology. Armed Forces Institute of Pathology, Washington, DC.

  7. Ahlbom HE (1935) Mucous- and salivary-gland tumours. A clinical study with special reference to radiotherapy, based on 254 cases treated at Radiumhemmet, Stockholm. Acta Radiol 16(Suppl 23)

  8. Ringertz N (1938) Pathology of malignant tumors arising in the nasal and paranasal cavities and maxilla. Medical Dissertation. Stockholm University, Sweden, p 450

  9. Škorpil F (1937) K patholigické anatomii a histologii epithelových nádorú slinných źlaz. Prometheus, Praha. [Czech]

  10. Lucas RB (1964) Pathology of tumours of the oral tissues. Churchill Livingstone, Edinburgh

    Google Scholar 

  11. Lucas RB, Eveson JW (1985) Atlas of oral pathology. Springer, Dordrecht

    Google Scholar 

  12. Thackray AC, Sobin LH, Eneroth C-M, Mathews WH, Pindborg JJ, Seifert G, Templeton AC, Teoh TB (1972) Histological typing of salivary gland tumours. WHO, Geneva

    Google Scholar 

  13. Thackray AC, Lucas RB (1974) Tumors of the major salivary glands. Atlas of tumor pathology. 2nd series. Fascicle 10. Armed Forces Institute of Pathology, Washington, DC.

  14. Friedmann I (1974) Pathology of the ear. Blackwell Scientific, Oxford

    Google Scholar 

  15. Friedmann I, Osborn DA (1982) Pathology of granulomas and neoplasms of the nose and paranasal sinuses. Churchill Livingstone, Edinburgh

    Google Scholar 

  16. Friedmann I, Ferlito A (1988) Granulomas and neoplasms of the larynx. Churchill Livingstone, Edinburgh

    Google Scholar 

  17. Seifert G, Sobin LH, Batsakis JG, Brocheriou C, Cardesa A, Dardick I, Ellis GL, Eveson JW, Gusterson BA, Shanmugaratnam K (1991) WHO histological typing of salivary gland tumours, 2nd edn. Springer-Verlag, Berlin

    Book  Google Scholar 

  18. Seifert G, Miehlke A, Haubrich J, Chilla R (1986) Diseases of the salivary glands. Georg Thieme Verlag, Stuttgart, Pathology-diagnosis-treatment-facial Nerve surgery

    Google Scholar 

  19. Donath K, Seifert G, Schmitz R (1972) Zur Diagnose und Ultrastruktur des tubulären Speichelgangcarcinoms. Epithelial-myoepitheliales Schaltstückcarcinom [Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts]. Virchows Arch A Pathol Pathol Anat 356:16–31 ([German])

    Article  CAS  PubMed  Google Scholar 

  20. Alberti PW, Bryce DP (1976) Workshops from the centennial conference on laryngeal cancer. Appleton-Century Crofts, New York.

  21. Shanmugaratnam K, Sobin L, Barnes L, Cardesa A, Ferlito A, Friedmann I, Heffner DK, Hellquist HB, Hyams VJ, Krueger GRF, Micheau C, Nascimento A (1991) WHO histological typing of tumours of the upper respiratory tract and ear, 2nd edn. Springer-Verlag, Berlin

    Book  Google Scholar 

  22. Michaels L, Wells M, Frohlich A (1983) A new technique for the study of temporal bone pathology. Clin Otolaryngol Allied Sci 8:77–85

    Article  CAS  PubMed  Google Scholar 

  23. Michaels L (1988) Origin of congenital cholesteatoma from a normally occurring epidermoid rest in the developing middle ear. Int J Pediatr Otorhinolaryngol 15:51–65

    Article  CAS  PubMed  Google Scholar 

  24. Michaels L (1996) Benign mucosal tumors of the nose and paranasal sinuses. Semin Diagn Pathol 13:113–117

    CAS  PubMed  Google Scholar 

  25. Michaels L (2007) Origin of endolymphatic sac tumor. Head Neck Pathol 1:104–111

    Article  PubMed  PubMed Central  Google Scholar 

  26. Michaels L, Soucek S (2011) Origin and growth of otosclerosis. Acta Otolaryngol 131:460–468

    Article  PubMed  Google Scholar 

  27. Michaels L (1984) Pathology of the larynx. Springer-Verlag, London

    Book  Google Scholar 

  28. Michaels L (1987) Ear, nose, and throat histopathology. Springer-Verlag, London

    Book  Google Scholar 

  29. Michaels L, Hellquist HB (2001) Ear, nose, and throat histopathology, 2nd edn. Springer, London

    Book  Google Scholar 

  30. Speight PM, Jordan R, Colloby P, Nandha H, Pringle JH (1994) Early detection of lymphomas in Sjögren’s syndrome by in situ hybridisation for kappa and lambda light chain mRNA in labial salivary glands. Eur J Cancer B Oral Oncol 30B:244–247

    Article  CAS  PubMed  Google Scholar 

  31. Speight PM (1995) Giant cell lesions of the jaws. Oral Dis 1:6–7

    Article  CAS  PubMed  Google Scholar 

  32. Speight PM, Abram TJ, Floriano PN, James R, Vick J, Thornhill MH et al (2015) Interobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trials. Oral Surg Oral Med Oral Pathol Oral Radiol 120:474-482.e2

    Article  PubMed  PubMed Central  Google Scholar 

  33. Speight PM, Khurram SA, Kujan O (2018) Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol 125:612–627

    Article  PubMed  Google Scholar 

  34. Speight PM, Farthing PM (2018) The pathology of oral cancer. Br Dent J 225:841–847

    Article  CAS  PubMed  Google Scholar 

  35. Eveson JW, Cawson RA (1985) Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. J Oral Pathol 14:500–509

    Article  CAS  PubMed  Google Scholar 

  36. Eveson JW, Cawson RA (1986) Warthin’s tumor (cystadenolymphoma) of salivary glands. A clinicopathologic investigation of 278 cases. Oral Surg Oral Med Oral Pathol 61:256–262

    Article  CAS  PubMed  Google Scholar 

  37. Eveson JW (1996) Granulomatous disorders of the oral mucosa. Semin Diagn Pathol 13:118–127

    CAS  PubMed  Google Scholar 

  38. Hague A, Eveson JW, MacFarlane M, Huntley S, Janghra N, Thavaraj S (2004) Caspase-3 expression is reduced, in the absence of cleavage, in terminally differentiated normal oral epithelium but is increased in oral squamous cell carcinomas and correlates with tumour stage. J Pathol 204:175–182

    Article  CAS  PubMed  Google Scholar 

  39. Scully C, Bagán JV, Eveson JW, Barnard N, Turner FM (2008) Sialosis: 35 cases of persistent parotid swelling from two countries. Br J Oral Maxillofac Surg 46:468–472

    Article  PubMed  Google Scholar 

  40. Klanrit P, Taebunpakul P, Flinterman MB, Odell EW, Riaz MA, Melino G et al (2009) PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers. Oncogene 28:3499–3512

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Bradley G, Odell EW, Raphael S, Ho J, Le LW, Benchimol S, Kaemel-Reid S (2010) Abnormal DNA content in oral epithelial dysplasia is associated with increased risk of progression to carcinoma. Br J Cancer 103:1432–1442

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Jee KJ, Persson M, Heikinheimo K, Passador-Santos F, Aro K, Knuutila S, Odell EW, Mäkitie A, Sundelin K, Stenman G, Leivo I (2013) Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma. Mod Pathol 26:213–222

    Article  CAS  PubMed  Google Scholar 

  43. Slootweg PJ, Odell EW, Baumhoer D, Carlos R, Hunter KD, Taylor AM, Richardson MS, Slater L, Speight PM, Wright J, Thompson LDR (2019) Data set for the reporting of malignant odontogenic tumors: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. Arch Pathol Lab Med 143:587–592

    Article  PubMed  Google Scholar 

  44. Coura BP, Bernardes VF, de Sousa SF, Diniz MG, Moreira RG, de Andrade BAB, Romañach MJ, Pontes HAR, Gomez RS, Odell EW, Gomes CC (2020) Targeted next-generation sequencing and allele-specific quantitative PCR of laser capture microdissected samples uncover molecular differences in mixed odontogenic tumors. J Mol Diagn 22:1393–1399

    Article  CAS  PubMed  Google Scholar 

  45. Di Palma S, Corletto V, Lavarino C, Birindelli S, Pilotti S (2000) Dedifferentiation in salivary gland carcinomas. Am J Surg Pathol 24:1439–1440

    Article  PubMed  Google Scholar 

  46. Di Palma S, Simpson RH, Marchiò C, Skálová A, Ungari M, Sandison A, Whitaker S, Parry S, Reis-Filho JS (2012) Salivary duct carcinomas can be classified into luminal androgen receptor-positive, HER2 and basal-like phenotypes. Histopathology 61:629–643

    Article  PubMed  Google Scholar 

  47. Di Palma S (2013) Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. Head Neck Pathol 7(Suppl 1):S68-76

    Article  PubMed  Google Scholar 

  48. Dalgleish AG, Di Palma S, Nathan K, Powell B, Patel N, Fusi A (2019) The successful treatment of metastatic androgen receptor-positive tumours of parotid origin with androgen receptor blockade and immunotherapy. Eur J Cancer 113:14–18

    Article  PubMed  Google Scholar 

  49. Xu B, Barbieri AL, Bishop JA, Chiosea SI, Dogan S, Di Palma S et al (2020) Histologic classification and molecular signature of polymorphous adenocarcinoma (PAC) and cribriform adenocarcinoma of salivary gland (CASG): an international interobserver study. Am J Surg Pathol 44:545–552

    Article  PubMed  PubMed Central  Google Scholar 

  50. Helliwell TR (2001) Molecular markers of metastasis in squamous carcinomas. J Pathol 194:289–293

    Article  CAS  PubMed  Google Scholar 

  51. Gomaa W, Ke Y, Fujii H, Helliwell T (2005) Tissue microarray of head and neck squamous carcinoma: validation of the methodology for the study of cutaneous fatty acid-binding protein, vascular endothelial growth factor, involucrin and Ki-67. Virchows Arch 447:701–709

    Article  CAS  PubMed  Google Scholar 

  52. Helliwell TR (2016) Non-infectious inflammatory lesions of the sinonasal tract. Head Neck Pathol 10:32–39

    Article  PubMed  PubMed Central  Google Scholar 

  53. Helliwell T, Chernock R, Dahlstrom JE, Gale N, McHugh J, Perez-Ordoñez B, Roland N, Zidar N, Thompson LDR (2019) Data set for the reporting of carcinomas of the hypopharynx, larynx, and trachea: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. Arch Pathol Lab Med 143:432–438

    Article  PubMed  Google Scholar 

  54. Gabusi A, Gissi DB, Montebugnoli L, Asioli S, Tarsitano A, Marchetti C, Balbi T, Helliwell TR, Foschini MP, Morandi L (2020) Prognostic impact of intra-field heterogeneity in oral squamous cell carcinoma. Virchows Arch 476:585–595

    Article  CAS  PubMed  Google Scholar 

  55. Tysome JR, Harcourt J, Patel MC, Sandison A, Michaels L (2008) Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm? Ear Nose Throat J 87:378–393

    Article  PubMed  Google Scholar 

  56. Bishop JA, Andreasen S, Hang JF, Bullock MJ, Chen TY, Franchi A, Garcia JJ, Gnepp DR, Gomez-Fernandez CR, Ihrler S, Kuo YJ, Lewis JS Jr, Magliocca KR, Pambuccian S, Sandison A, Uro-Coste E, Stelow E, Kiss K, Westra WH (2017) HPV-related multiphenotypic sinonasal carcinoma: an expanded series of 49 cases of the tumor formerly known as HPV-related carcinoma with adenoid cystic carcinoma-like features. Am J Surg Pathol 41:1690–1701

    Article  PubMed  PubMed Central  Google Scholar 

  57. Gupta R, Sandison A, Wenig BM, Thompson LDR (2019) Data set for the reporting of ear and temporal bone tumors: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. Arch Pathol Lab Med 143:593–602

    Article  PubMed  Google Scholar 

  58. Ruangritchankul K, Sandison A, Warburton F, Guerrero-Urbano T, Reis Ferreira M, Lei M, Thavaraj S (2019) Clinical evaluation of tumour-infiltrating lymphocytes as a prognostic factor in patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma. Histopathology 75:146–150

    Article  PubMed  Google Scholar 

  59. Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA (2021) DEK-AFF2 carcinoma of the sinonasal region and skull base: detailed clinicopathologic characterization of a distinctive entity. Am J Surg Pathol 45:1682–1693

    Article  PubMed  Google Scholar 

  60. Simpson RHW, Sarsfield PTL, Clarke T, Babajews AV (1990) Clear cell carcinoma of minor salivary glands. Histopathology 17:433–438

    Article  CAS  PubMed  Google Scholar 

  61. Simpson RHW, Prasad AR, Lewis JE, Skálová A, David L (2003) Mucin-rich variant of salivary duct carcinoma: a clinicopathological and immunohistochemical study of four cases. Am J Surg Pathol 27:1070–1079

    Article  PubMed  Google Scholar 

  62. Simpson RHW, Desai S, Di Palma S (2008) Salivary duct carcinoma in situ of the parotid gland. Histopathology 53:416–425

    Article  CAS  PubMed  Google Scholar 

  63. Simpson RHW (2013) Salivary duct carcinoma: new developments – morphological variants including pure in situ high grade lesions; proposed molecular classification. Head Neck Pathol 7(Suppl 1):S48-58

    Article  PubMed  Google Scholar 

  64. Simpson RHW, Skálová A, Di Palma S, Leivo I (2014) Recent advances in the diagnostic pathology of salivary carcinomas. Virchows Arch 465:371–384

    Article  CAS  PubMed  Google Scholar 

  65. Jares P, Fernández PL, Campo E, Nadal A, Bosch F, Aiza G, Nayash I, Traserra J, Cardesa A (1994) PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res 54:4813–4817

    CAS  PubMed  Google Scholar 

  66. Jares P, Fernández PL, Nadal A, Cazorla M, Hernández L, Pinyol M, Hernández S, Traserra J, Cardesa A (1997) p16MTS1/CDK4I mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx. Oncogene 15:1445–1453

    Article  CAS  PubMed  Google Scholar 

  67. Skalova A, Cardesa A, Leivo I, Pfaltz M, Ryska A, Simpson R, Michal M (2003) Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entity. Virchows Arch 443:152–158

    Article  CAS  PubMed  Google Scholar 

  68. Romeu C, Farré X, Cardesa A, Nadal A (2013) Expression of Ep-CAM, but not of E48, associates with nodal involvement in advanced squamous cell carcinomas of the larynx. Histopathology 62:954–961

    Article  PubMed  Google Scholar 

  69. Gale N, Cardesa A, Hernandez-Prera JC, Slootweg PJ, Wenig BM, Zidar N (2020) Laryngeal dysplasia: persisting dilemmas, disagreements and unsolved problems-a short review. Head Neck Pathol 14:1046–1051

    Article  PubMed  PubMed Central  Google Scholar 

  70. Barnes L, Eveson JW, Reichert P, Sidranski D (2005) (eds). Pathology and genetics of head and neck tumours. World Health Organization classification of tumours. IARC Press, Lyon.

  71. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (2017) (eds). WHO classification of head and neck tumours. IARC, Lyon

  72. Cardesa A, Slootweg PJ (2006) (eds). Pathology of the head and neck. Springer, Berlin

  73. Cardesa A, Slootweg PJ, Gale N, Franchi A (2016) (eds). Pathology of the head and neck. 2nd edn, Springer, Berlin

  74. Nadal A, Campo E, Pinto J, Mallofré C, Palacín A, Arias C, Traserra J, Cardesa A (1995) p53 expression in normal, dysplastic, and neoplastic laryngeal epithelium. Absence of a correlation with prognostic factors. J Pathol 175:181–188

    Article  CAS  PubMed  Google Scholar 

  75. Nadal A, Jares P, Cazorla M, Fernández PL, Sanjuan X, Hernández L, Pinyol M, Aldea M, Mallofré C, Muntané J, Traserra J, Campo E, Cardesa A (1997) p21WAF1/CIP1 expression is associated with cell differentiation but not p53 mutations in squamous cell carcinomas of the larynx. J Pathol 183:156–163

    Article  CAS  PubMed  Google Scholar 

  76. Conde L, Vilaseca I, Alós L, Bernal-Sprekelsen M, Cardesa A, Nadal A (2012) Methyilthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma. Histopathology 61:1082–1088

    Article  PubMed  Google Scholar 

  77. Larque AB, Conde L, Hakim S, Alós L, Jares P, Vilaseca I, Cardesa A, Nadal A (2015) p16(INK4a) overexpression is associated with CDKN2A mutation and worse prognosis in HPV-negative laryngeal squamous cell carcinomas. Virchows Arch 466:375–382

    Article  CAS  PubMed  Google Scholar 

  78. Acuña G, Gomà M, Temprana-Salvador J, Garcia-Bragado F, Alós L, Ordi J, Cardesa A, Nadal A (2019) Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma. Mod Pathol 32:621–626

    Article  PubMed  Google Scholar 

  79. Alós L, Castillo M, Nadal A, Caballero M, Mallofré C, Palacín A, Cardesa A (2004) Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases. Histopathology 44:570–579

    Article  PubMed  Google Scholar 

  80. Alós L, Luján B, Castillo M, Nadal A, Carrera M, Caballero M, De Bolós C, Cardesa A (2005) Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands. Am J Surg Pathol 29:806–813

    Article  PubMed  Google Scholar 

  81. Larque AB, Hakim S, Ordi J, Nadal A, Diaz A, del Pino M, Marimon L, Alobid I, Cardesa A, Alós L (2014) High-risk human papillomavirus is transcriptionally active in a subset of sinonasal squamous cell carcinomas. Mod Pathol 27:343–351

    Article  CAS  PubMed  Google Scholar 

  82. Alós L, Hakim S, Larque AB, de la Oliva J, Rodriguez-Carunchio L, Caballero M, Nadal A, Marti C, Guimera N, Fernandez-Figueras MT, Quint W, Ordi J (2016) p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas. Virchows Arch 469:277–284

    Article  PubMed  CAS  Google Scholar 

  83. de la Oliva J, Larque AB, Marti C, Bodalo-Torruella M, Nonell L, Nadal A, Castillo P, Sieira R, Ferrer A, Garcia-Diez E, Alós L (2021) Oral premalignant lesions of smokers and non-smokers show similar carcinogenic pathways and outcomes. A clinicopathological and molecular comparative analysis. J Oral Pathol Med 50:280–286

    Article  PubMed  CAS  Google Scholar 

  84. van Es RJ, Keus RB, van der Waal I, Koole R, Vermey A (1997) Osteosarcoma of the jaw bones. Long-term follow up of 48 cases. Int J Oral Maxillofac Surg 26:191–197

    PubMed  Google Scholar 

  85. van der Waal I (2009) Oral lichen planus and oral lichenoid lesions: a critical appraisal with emphasis on the diagnostic aspects. Med Oral Patol Oral Cir Bucal 14:E310-314

    PubMed  Google Scholar 

  86. Hertog D, van der Waal I (2010) Ameloblastoma of the jaws: a critical reappraisal based on a 40-years single institution experience. Oral Oncol 46:61–64

    Article  PubMed  Google Scholar 

  87. Meleti M, van der Waal I (2013) Clinicopathological evaluation of 164 dental follicles and dentigerous cysts with emphasis on the presence of odontogenic epithelium in the connective tissue. The hypothesis of “focal ameloblastoma.” Med Oral Patol Oral Cir Bucal 18:e60-64

    Article  PubMed  Google Scholar 

  88. Bodner L, Manor E, Friger MD, van der Waal I (2014) Oral squamous cell carcinoma in patients twenty years of age or younger—review and analysis of 186 reported cases. Oral Oncol 50:84–89

    Article  PubMed  Google Scholar 

  89. van der Waal I, Sreeby LM (1996) Diseases of the salivary glands including dry mouth and Sjögren’s syndrome. Diagnosis and treatment. Springer, Heidelberg

  90. van der Waal I (2015) Atlas of oral diseases: a guide for daily practice. Springer, Heidelberg

    Google Scholar 

  91. Roepman P, Wessels LF, Kettelarij N, Kemmeren P, Miles AJ, Lijnzaad P, Tilanus MG, Koole R, Hordijk GJ, van der Vliet PC, Reinders MJ, Slootweg PJ, Holstege FC (2005) An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet 37:182–186

    Article  CAS  PubMed  Google Scholar 

  92. Flucke U, Tops BB, van Diest PJ, Slootweg PJ (2014) Desmoid-type fibromatosis of the head and neck region in the paediatric population: a clinicopathological and genetic study of seven cases. Histopathology 64:769–776

    Article  PubMed  Google Scholar 

  93. Hoeben A, van de Winkel L, Hoebers F, Kross K, Driessen C, Slootweg P, Tjan-Heijnen VC, van Herpen C (2016) Intestinal-type sinonasal adenocarcinomas: the road to molecular diagnosis and personalized treatment. Head Neck 38:1564–1570

    Article  PubMed  Google Scholar 

  94. Sturm B, Fleskens SJ, Bot FJ, van Velthuysen ML, Speel EJ, Slootweg PJ, van der Laak JA (2014) Virtual microscopy is a valid alternative for the diagnostic assessment of laryngeal premalignancies. Histopathology 64:602–604

    Article  PubMed  Google Scholar 

  95. Vogels R, Baumhoer D, van Gorp J, Eijkelenboom A, Verdijk M, van Cleef P, Bloemena E, Slootweg PJ, Lohman B, Debiec-Rychter M, Flucke U (2019) Clear cell odontogenic carcinoma: occurrence of EWSR1-CREB1 as alternative fusion gene to EWSR1-ATF1. Head Neck Pathol 13:225–230

    Article  PubMed  Google Scholar 

  96. Slootweg PJ (2006) Dental pathology. A practical introduction, Springer, Heidelberg

    Google Scholar 

  97. Slootweg PJ (2013) Dental pathology. A practical introduction. 2nd ed, Springer, Heidelberg

  98. Slootweg PJ (2015) Pathology of the maxillofacial bones. A diagnostic guide, Springer, Heidelberg

    Book  Google Scholar 

  99. Kambič V, Gale N (1995) Epithelial hyperplastic lesions of the larynx. Elsevier, Amsterdam

    Google Scholar 

  100. Gale N, Kambic V, Michaels L, Cardesa A, Hellquist H, Zidar N, Poljak M (2000) The Ljubljana classification: a practical strategy for the diagnosis of laryngeal precancerous lesions. Adv Anat Pathol 7:240–251

    Article  CAS  PubMed  Google Scholar 

  101. Glavac D, Volavšek M, Potocnik U, Ravnik-Glavac M, Gale N (2003) Low microsatellite instability and high loss of heterozygosity rates indicate dominant role of the suppressor pathway in squamous cell carcinoma of head and neck and loss of heterozygosity of 11q14.3 correlates with tumor grade. Cancer Genet Cytogenet 146:27–32

    Article  CAS  PubMed  Google Scholar 

  102. Gale N, Blagus R, El-Mofty SK, Helliwell T, Prasad ML, Sandison A, Volavšek M, Wenig BM, Zidar N, Cardesa A (2014) Evaluation of a new grading system for laryngeal squamous intraepithelial lesions–a proposed unified classification. Histopathology 65:456–464

    Article  PubMed  Google Scholar 

  103. Gluvajić D, Hošnjak L, Stegel V, Novaković S, Gale N, Poljak M, Boltežar IH (2020) Risk factors for the development of high-grade dysplasia and carcinoma in patients with laryngeal squamous cell papillomas: large retrospective cohort study. Head Neck. https://doi.org/10.1002/hed.26560

    Article  PubMed  Google Scholar 

  104. Gale N, Poljak M, Volavšek M, Hošnjak L, Velkavrh D, Bolha L, Komloš KF, Strojan P, Aničin A, Zidar N (2021) Usefulness of high-risk human papillomavirus mRNA silver in situ hybridization diagnostic assay in oropharyngeal squamous cell carcinomas. Pathol Res Pract 2021 226:153585

  105. Zidar N, Boštjančič E, Gale N, Kojc N, Poljak M, Glavač D, Cardesa A (2011) Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck—hallmark of epithelial-mesenchymal transition. Hum Pathol 42:482–488

    Article  CAS  PubMed  Google Scholar 

  106. Odar K, Kocjan BJ, Hošnjak L, Gale N, Poljak M, Zidar N (2014) Verrucous carcinoma of the head and neck - not a human papillomavirus-related tumour? J Cell Mol Med 18:635–645

    Article  CAS  PubMed  Google Scholar 

  107. Zidar N, Gale N (2015) Carcinosarcoma and spindle cell carcinoma—monoclonal neoplasms undergoing epithelial-mesenchymal transition. Virchows Arch 466:357–358

    Article  PubMed  Google Scholar 

  108. Zidar N, Boštjančič E, Malgaj M, Gale N, Dovšak T, Didanovič V (2018) The role of epithelial-mesenchymal transition in squamous cell carcinoma of the oral cavity. Virchows Arch 472:237–245

    Article  CAS  PubMed  Google Scholar 

  109. Grubelnik G, Boštjančič E, Aničin A, Dovšak T (2021) Zidar N (2021) MicroRNAs and long non-coding RNAs as regulators of NANOG expression in the development of oral squamous cell carcinoma. Front Oncol 10:579053. https://doi.org/10.3389/fonc.2020.579053

    Article  PubMed  PubMed Central  Google Scholar 

  110. Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, Starek I, Geierova M, Simpson RH, Passador-Santos F, Ryska A, Leivo I, Kinkor Z, Michal M (2010) Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol 34:599–608

    Article  PubMed  Google Scholar 

  111. Skálová A, Banĕčková M, Laco J, Di Palma S, Agaimy A, Ptáková N et al (2021) Sclerosing polycystic adenoma of salivary glands: a novel neoplasm characterized by PI3K-AKT pathway alterations – new insights into a challenging entity. Am J Surg Pathol. 2021; Sep 13. Online ahead of print

  112. Skálová A, Gnepp DR, Simpson RH, Lewis JE, Janssen D, Sima R, Vanecek T, Di Palma S, Michal M (2006) Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker. Am J Surg Pathol 30:939–944

    Article  PubMed  Google Scholar 

  113. Skalova A, Sima R, Kaspirkova-Nemcova J, Simpson RH, Elmberger G, Leivo I, Di Palma S, Jirasek T, Gnepp DR, Weinreb I, Perez-Ordoñez B, Mukensnabl P, Rychly B, Hrabal P, Michal M (2011) Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol 35:1168–1176

    Article  PubMed  Google Scholar 

  114. Hellquist H, Skalova A (2014) Histopathology of the salivary glands. Springer, Heidelberg

    Book  Google Scholar 

  115. Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A (2018) The role of molecular testing in the differential diagnosis of salivary gland carcinomas. Am J Surg Pathol 42:e11–e27

    Article  PubMed  Google Scholar 

  116. Skálová A, Ptáková N, Santana T, Agaimy A, Ihrler S, Uro-Coste E, Thompson LDR, Bishop JA, Baněčkova M, Rupp NJ, Morbini P, de Sanctis S, Schiavo-Lena M, Vanecek T, Michal M, Leivo I (2019) NCOA4-RET and TRIM27-RET are characteristic gene fusions in salivary intraductal carcinoma, including invasive and metastatic tumors: is “intraductal” correct? Am J Surg Pathol 43:1303–1313

    Article  PubMed  Google Scholar 

  117. Thompson LDR, Lewis JS Jr, Skálová A, Bishop JA (2020) Don’t stop the champions of research now: a brief history of head and neck pathology developments. Hum Pathol 95:1–23

    Article  PubMed  Google Scholar 

  118. Skalova A, Leivo I, Hellquist H, Agaimy A, Simpson RHW, Stenman G, Vander Poorten V, Bishop JA, Franchi A, Hernandez-Prera JC, Slouka D, Willems SM, Olsen KD, Ferlito A (2021) High-grade transformation/dedifferentiation in salivary gland carcinomas: occurrence across subtypes and clinical significance. Adv Anat Pathol 28:107–118

    Article  CAS  PubMed  Google Scholar 

  119. Ferlito A, Strojan P, Lewis JS Jr, Perez-Ordoñez B, Rinaldo A (2014) Large cell neuroendocrine carcinoma of the head and neck: a distinct clinicopathologic entity. Eur Arch Otorhinolaryngol 271:2093–2095

    Article  PubMed  Google Scholar 

  120. Ferlito A, Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Devaney KO, Hunt JL, Perez-Ordoñez B, Slootweg PJ, Bell D, Bishop JA, Rinaldo A (2015) New tumor phenotypes reported in the larynx in the last decades: a critique. Am J Otolaryngol 36:494–497

    Article  PubMed  Google Scholar 

  121. Ferlito A, Rinaldo A, Bishop JA, Hunt JL, Vander Poorten V, Williams MD, Triantafyllou A, Devaney KO, Gnepp DR, Kusafuka K, Halmos GB, Westra WH, Takes RP, Thompson LD (2016) Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance. Eur Arch Otorhinolaryngol 273:533–536

    Article  PubMed  Google Scholar 

  122. Ferlito A, Devaney KO, Hunt JL, Hellquist H (2019) Some considerations on the WHO histological classification of laryngeal neoplasms. Adv Ther 36:1511–1517

    Article  PubMed  PubMed Central  Google Scholar 

  123. Ferlito A, Devaney KO, Mäkitie AA (2019) Differing characteristics of cartilaginous lesions of the larynx. Eur Arch Otorhinolaryngol 276:2635–2647

    Article  PubMed  PubMed Central  Google Scholar 

  124. Ferlito A (1993) Neoplasms of the larynx. Churchill Livingstone, Edinburgh

    Google Scholar 

  125. Ferlito A (1996) Surgical pathology of laryngeal neoplasms. Chapman & Hall, London

    Google Scholar 

  126. Franchi A, Moroni M, Massi D, Paglierani M, Santucci M (2002) Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns. Am J Surg Pathol 26:1597–1604

    Article  PubMed  Google Scholar 

  127. Franchi A, Fondi C, Paglierani M, Pepi M, Gallo O, Santucci M (2009) Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinoma. Oral Oncol 45:835–838

    Article  CAS  PubMed  Google Scholar 

  128. Franchi A, Palomba A, Fondi C, Miligi L, Paglierani M, Pepi M, Santucci M (2011) Immunohistochemical investigation of tumorigenic pathways in sinonasal intestinal-type adenocarcinoma. A tissue microarray analysis of 62 cases. Histopathology 59:98–105

    Article  PubMed  Google Scholar 

  129. Franchi A, Palomba A, Miligi L, Ranucci V, Innocenti DR, Simoni A, Pepi M, Santucci M (2015) Intestinal metaplasia of the sinonasal mucosa adjacent to intestinal-type adenocarcinoma. A morphologic, immunohistochemical, and molecular study. Virchows Arch 466:161–168

    Article  CAS  PubMed  Google Scholar 

  130. Franchi A, Bishop JA, Coleman H, Flucke U, Licitra LF, Pendás JLL, Stelow EB, Toner M, Weinreb I, Wenig BM, Thompson LDR (2019) Data set for the reporting of carcinomas of the nasal cavity and paranasal sinuses: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. Arch Pathol Lab Med 143:603–609

    Article  PubMed  Google Scholar 

  131. Franchi A (2020) Pathology of sinonasal tumors and tumor-like lesions. Springer, Cham

    Book  Google Scholar 

  132. Faquin WC, Rossi ED, Baloch Z, Barkan GA, Foschini MP, Kurtycz DFI et al (2018) The Milan system for reporting salivary gland cytopathology. Springer International Publishing AG

  133. Vékony H, Röser K, Löning T, Ylstra B, Meijer GA, van Wieringen WN et al (2009) Copy number gain at 8q12.1-q22.1 is associated with a malignant tumor phenotype in salivary gland myoepitheliomas. Genes Chromosomes Cancer 48:202–12

    Article  PubMed  CAS  Google Scholar 

  134. Dahl A, Teegen J, Altevogt P, Löning T, Schumacher U (2011) Glycoconjugate expression in adenoid cystic carcinoma of the salivary glands: up-regulation of L1 predicts fatal prognosis. Histopathology 59:299–307

    Article  PubMed  Google Scholar 

  135. Fehr A, Kovács A, Löning T, Frierson H Jr, van den Oord J, Stenman G (2011) The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. J Pathol 224:322–327

    Article  CAS  PubMed  Google Scholar 

  136. Friedrich RE, Dilcher J, Jaehne M, Löning T (2012) Chromosomal rearrangements in PLAG1 of myoepithelial salivary gland tumours. Anticancer Res 32:1977–1981

    CAS  PubMed  Google Scholar 

  137. Fehr A, Werenicz S, Trocchi P, Falk M, Friedrich RE, Stammler A, Stang A, Oesterling F, Khil L, Stenman G, Böcker W, Tiemann K, Löning T (2021) Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping. Virchows Arch 479:975–985

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  138. Löning T, Reichart P, Staquet MJ, Becker J, Thivolet J (1984) Occurrence of papillomavirus structural antigens in oral papillomas and leukoplakias. J Oral Pathol 13:155–165

    Article  PubMed  Google Scholar 

  139. Ihrler S, Baretton GB, Menauer F, Blasenbreu-Vogt S, Löhrs U (2000) Sjögren’s syndrome and MALT lymphomas of salivary glands: a DNA-cytometric and interphase-cytogenetic study. Mod Pathol 13:4–12

    Article  CAS  PubMed  Google Scholar 

  140. Weiler C, Reu S, Zengel P, Kirchner T, Ihrler S (2009) Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma. Pathol Res Pract 205:838–842

    Article  CAS  PubMed  Google Scholar 

  141. Ihrler S, Guntinas-Lichius O, Agaimy A, Wolf A, Mollenhauer M (2017) Histological, immunohistological and molecular characteristics of intraductal precursor of carcinoma ex pleomorphic adenoma support a multistep carcinogenic process. Virchows Arch 470:601–609

    Article  CAS  PubMed  Google Scholar 

  142. Agaimy A, Baněčková M, Ihrler S, Mueller SK, Franchi A, Hartmann A, Stoehr R, Skálová A (2021) ALK rearrangements characterize 2 distinct types of salivary gland carcinomas: clinicopathologic and molecular analysis of 4 cases and literature review. Am J Surg Pathol 45:1166–1178

    Article  PubMed  Google Scholar 

  143. Ihrler S, Agaimy A, Guntinas-Lichius O, Haas CJ, Mollenhauer M, Sandison A, Greber L (2021) Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult? Histopathology 79:779–790

    Article  PubMed  Google Scholar 

  144. Agaimy A, Koch M, Lell M, Semrau S, Dudek W, Wachter DL, Knöll A, Iro H, Haller F, Hartmann A (2014) SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms. Am J Surg Pathol 38:1274–1281

    Article  PubMed  PubMed Central  Google Scholar 

  145. Agaimy A, Hartmann A, Antonescu CR, Chiosea SI, El-Mofty SK, Geddert H, Iro H, Lewis JS Jr, Märkl B, Mills SE, Riener MO, Robertson T, Sandison A, Semrau S, Simpson RH, Stelow E, Westra WH, Bishop JA (2017) SMARCB1 (INI-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity. Am J Surg Pathol 41:458–471

    Article  PubMed  PubMed Central  Google Scholar 

  146. Agaimy A, Jain D, Uddin N, Rooper LM, Bishop JA (2020) SMARCA-deficient sinonasal carcinoma: a series of 10 cases expanding the genetic spectrum of SWI/SNF-driven sinonasal malignancies. Am J Surg Pathol 44:703–710

    Article  PubMed  Google Scholar 

  147. Haller F, Bieg M, Will R, Körner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bähr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S, Agaimy A (2019) Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Nat Commun 10(1):368. https://doi.org/10.1038/s41467-018-08069-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  148. Haller F, Skálová A, Ihrler S, Märkl B, Bieg M, Moskalev EA, Erber R, Blank S, Winkelmann C, Hebele S, Baněčková M, Wiemann S, Müller S, Zenk J, Eils R, Iro H, Hartmann A, Agaimy A (2019) Nuclear NR4A3 immunostaining is a specific and sensitive novel marker for acinic cell carcinoma of the salivary glands. Am J Surg Pathol 43:1264–1272

    Article  PubMed  Google Scholar 

  149. Agaimy A, Ihrler S, Baněčková M, Costés Martineau V, Mantsopoulos K, Hartmann A, Iro H, Stoehr R, Skálová A (2021) HMGA2-WIF1 rearrangements characterize a distinctive subset of salivary pleomorphic adenomas with prominent trabecular (canalicular adenoma-like) morphology. A. Am J Surg Pathol. 2021 Jul 29. https://doi.org/10.1097/PAS.0000000000001783. Online ahead of print

  150. Agaimy A, Witkowski L, Stoehr R, Cuenca JCC, González-Muller CA, Brütting A, Bährle M, Mantsopoulos K, Amin RMS, Hartmann A, Metzler M, Amr SS, Foulkes WD, Sobrinho-Simões M, Eloy C (2020) Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term “thyroblastoma” more appropriate? Virchows Arch 477:787–798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  151. Syrjänen K, Syrjänen S, Pyrhönen S (1982) Human papilloma virus (HPV) antigens in lesions of laryngeal squamous cell carcinomas. ORL J Otorhinolaryngol Relat Spec 44:323–334

    Article  PubMed  Google Scholar 

  152. Syrjänen S, Rautava J, Syrjänen K (2017) HPV in head and neck cancer-30 years of history. Recent Results Cancer Res 206:3–25

    Article  PubMed  Google Scholar 

  153. Randén-Brady R, Carpén T, Jouhi L, Syrjänen S, Haglund C, Tarkkanen J, Remes S, Mäkitie A, Mattila PS, Silén S, Hagström J (2019) In situ hybridization for high-risk HPV E6/E7 mRNA is a superior method for detecting transcriptionally active HPV in oropharyngeal cancer. Hum Pathol 90:97–105

    Article  PubMed  CAS  Google Scholar 

  154. Paaso A, Koskimaa HM, Welters MJP, Kero K, Rautava J, Syrjänen K, van der Burg SH, Syrjänen S (2021) Interferon-γ and IL-5 associated cell-mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa. Clin Exp Dent Res 7:903–913

    Article  PubMed  PubMed Central  Google Scholar 

  155. Sjöblom A, Stenman UH, Hagström J, Jouhi L, Haglund C, Syrjänen S, Mattila P, Mäkitie A, Carpén T (2021) Tumor-associated trypsin inhibitor (TATI) as a biomarker of poor prognosis in oropharyngeal squamous cell carcinoma irrespective of HPV status. Cancers (Basel) 13(11):2811. https://doi.org/10.3390/cancers13112811

    Article  CAS  Google Scholar 

  156. Leivo I, Engvall E (1988) Merosin, a protein specific for basement membranes of Schwann cells, striated muscle, and trophoblast, is expressed late in nerve and muscle development. Proc Natl Acad Sci USA 85:1544–1548

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  157. Almangush A, Pirinen M, Heikkinen I, Mäkitie AA, Salo T, Leivo I (2018) Tumour budding in oral squamous cell carcinoma: a meta-analysis. Br J Cancer 118:577–586

    Article  PubMed  Google Scholar 

  158. Ruuskanen M, Irjala H, Minn H, Vahlberg T, Randen-Brady R, Hagström J, Syrjänen S, Leivo I (2019) Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma: a nationwide study in Finland. Head Neck 41:349–357

    PubMed  Google Scholar 

  159. Leivo I, Holmila R, Luce D, Steiniche T, Dictor M, Heikkilä P, Husgafvel-Pursiainen K, Wolff H (2021) Occurrence of sinonasal intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma in two countries with different patterns of wood dust exposure. Cancers (Basel) 13(20):5245. https://doi.org/10.3390/cancers13205245

    Article  CAS  Google Scholar 

  160. Mark J, Dahlenfors R, Ekedahl C, Stenman G (1980) The mixed salivary gland tumor - a normally benign human neoplasm frequently showing specific chromosome abnormalities. Cancer Genet Cytogenet 2:231–241

    Article  Google Scholar 

  161. Kas K, Voz M, Röijer E, Åström A-K, Meynen E, Stenman G, Van de Ven W (1997) Promoter swapping between the genes for a novel zink finger protein and β-catenin in pleomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet 15:170–174

    Article  CAS  PubMed  Google Scholar 

  162. Persson M, Andrén Y, Mark J, Horlings HM, Persson F, Stenman G (2009) Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci USA 106:18740–18744

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  163. Andersson MK, Stenman G (2016) The landscape of gene fusions and somatic mutations in salivary gland neoplasms – implications for diagnosis and therapy. Oral Oncol 57:63–69

    Article  CAS  PubMed  Google Scholar 

  164. Andersson MK, Afshar MK, Andrén Y, Wick MJ, Stenman G (2017) Targeting the oncogenic transcriptional regulator MYB in adenoid cystic carcinoma by inhibition of IGF1R-AKT signaling. J Natl Cancer Inst 2017 109(9). https://doi.org/10.1093/jnci/djx017

  165. Hellquist HB (1990) Pathology of the nose and paranasal sinuses. Butterworths, London

    Google Scholar 

  166. Hellquist H, Lundgren J, Olofsson J (1982) Hyperplasia, keratosis, dysplasia and carcinoma in situ of the vocal cords—a follow-up study. Clin Otolaryngol Allied Sci 7:11–27

    Article  CAS  PubMed  Google Scholar 

  167. Hellquist HB, Karlsson MG, Nilsson C (1994) Salivary duct carcinoma—a highly aggressive salivary gland tumour with overexpression of c-erbB-2. J Pathol 172:35–44

    Article  CAS  PubMed  Google Scholar 

  168. Hellquist HB, Sundelin K, Di Bacco A, Tytor M, Manzotti M, Viale G (1997) Tumour growth fraction and apoptosis in salivary gland acinic cell carcinomas. Prognostic implications of Ki-67 and bcl-2 expression and of in situ end labelling (TUNEL). J Pathol 181:323–329

    Article  CAS  PubMed  Google Scholar 

  169. Hellquist H, Cardesa A, Gale N, Kambic V, Michaels L (1999) Criteria for grading in the Ljubljana classification of epithelial hyperplastic laryngeal lesions. A study by members of the Working Group on Epithelial Hyperplastic Laryngeal Lesions of the European Society of Pathology. Histopathology 34:226–233

    Article  CAS  PubMed  Google Scholar 

  170. Hellquist H, Skalova A, Azadeh B (2016) Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm? Virchows Arch 469:643–650

    Article  CAS  PubMed  Google Scholar 

  171. Heegaard S, Grossniklaus H (2016) Eye pathology: an illustrated guide. Springer

    Google Scholar 

  172. Klijanienko J, Lagacé R, Servois V, Lussier C, El-Naggar AK, Vielh P (2001) Fine-needle sampling of primary neuroendocrine carcinomas of salivary glands: cytohistological correlations and clinical analysis. Diagn Cytopathol 24:163–166

    Article  CAS  PubMed  Google Scholar 

  173. Theocharis S, Klijanienko J, Giaginis C, Rodriguez J, Jouffroy T, Girod A, Point D, Tsourouflis G, Sastre-Garau X (2011) Metallothionein expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patient survival. Histopathology 59:514–525

    Article  PubMed  Google Scholar 

  174. Dubot C, Bernard V, Sablin MP, Vacher S, Chemlali W, Schnitzler A, Pierron G, Ait Rais K, Bessoltane N, Jeannot E, Klijanienko J, Mariani O, Jouffroy T, Calugaru V, Hoffmann C, Lesnik M, Badois N, Berger F, Le Tourneau C, Kamal M, Bieche I (2018) Comprehensive genomic profiling of head and neck squamous cell carcinoma reveals FGFR1 amplifications and tumour genomic alterations burden as prognostic biomarkers of survival. Eur J Cancer 91:47–55

    Article  CAS  PubMed  Google Scholar 

  175. Maleki Z, Baloch Z, Lu R, Shafique K, Song SJ, Viswanathan K, Rao RA, Lefler H, Fatima A, Wiles A, Jo VY, Wang H, Fadda G, Powers CN, Ali SZ, Pantanowitz L, Siddiqui MT, Nayar R, Klijanienko J et al (2019) Application of the Milan system for reporting submandibular gland cytopathology: an international, multi-institutional study. Cancer Cytopathol 127:306–315

    Article  PubMed  PubMed Central  Google Scholar 

  176. Marginean FE, Lesnik M, Gauthier A, Klijanienko J (2021) The accurate cytological diagnosis of salivary carcinoma ex pleomorphic adenoma may be hampered by myoepithelial differentiation. Cytopathology 32:527–530

    Article  PubMed  Google Scholar 

  177. Baloch Z, Fadda G, First P, Klijanienko J, Krane JF et al (2018) Neoplasm. In: Baloch Z, Barkan GA, Foschini MP, Kurtycz DFI (eds) Faquin WC, Rossi. Milan system for reporting salivary gland cytopathology. Springer International Publishing AG, The, pp 55–83

  178. Lussier C, Klijanienko J, Vielh P (2000) Fine-needle aspiration of metastatic nonlymphomatous tumors to the major salivary glands: a clinicopathologic study of 40 cases cytologically diagnosed and histologically correlated. Cancer 90:350–356

    Article  CAS  PubMed  Google Scholar 

  179. Hasmim M, Badoual C, Vielh P, Drusch F, Marty V, Laplanche A, de Oliveira DM, Roussel H, De Guillebon E, Oudard S, Hans S, Tartour E, Chouaib S (2013) Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells. BMC Cancer 11(13):592. https://doi.org/10.1186/1471-2407-13-592

    Article  CAS  Google Scholar 

  180. Lacroix L, Post SF, Valent A, Melkane AE, Vielh P, Egile C, Castell C, Larois C, Micallef S, Saulnier P, Goulaouic H, Lefebvre AM, Temam S (2014) MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinoma. PLoS ONE 9(1):e84319. https://doi.org/10.1371/journal.pone.0084319.eCollection2014

    Article  PubMed  PubMed Central  Google Scholar 

  181. Pusztaszeri M, Baloch Z, Vielh P, Faquin WC (2018) Application of the Milan system for reporting risk stratification in salivary gland cytopathology. Cancer Cytopathol 126:69–70

    Article  PubMed  Google Scholar 

  182. Johnson DN, Onenerk M, Krane JF, Rossi ED, Baloch Z, Barkan G, Bongiovanni M, Callegari F, Canberk S, Dixon G, Field A, Griffith CC, Jhala N, Jiang S, Kurtycz D, Layfield L, Lin O, Maleki Z, Perez-Machado M, Pusztaszeri M, Vielh P, Wang H, Zarka MA, Faquin WC (2020) Cytologic grading of primary malignant salivary gland tumors: a blinded review by an international panel. Cancer Cytopathol 128:392–402

    Article  PubMed  PubMed Central  Google Scholar 

  183. Kocjan G, Gray W, Levine T, Kardum-Skelin I, Viehl P (2013) Diagnostic Cytopathology Essential E-book, 1st edn. Churchill-Livingstone, Kindle edn, p 450

  184. Fonseca I, Clode AL, Soares J (1993) Mucoepidermoid carcinoma of major and minor salivary glands: a survey of 43 cases with study of prognostic indicators. Int J Surg Pathol 1:3–11

    Article  Google Scholar 

  185. Queimado L, Reis A, Fonseca I, Martins C, Lovett M, Soares J, Parreira L (1998) A refined localization of two deleted regions in chromosome 6q associated with salivary gland carcinomas. Oncogene 16:83–88

    Article  CAS  PubMed  Google Scholar 

  186. Félix A, Rosa JC, Fonseca I, Cidadão A, Soares J (1999) Laminin and collagen IV in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: an immunohistochemical study. Hum Pathol 30:964–969

    Article  PubMed  Google Scholar 

  187. Fonseca I, Pereira T, Rosa-Santos J, Soares J (2001) Expression of CD44 isoforms in squamous cell carcinoma of the border of the tongue: a correlation with histological grade, pattern of stromal invasion, and cell differentiation. J Surg Oncol 76:115–120

    Article  CAS  PubMed  Google Scholar 

  188. Martins C, Fonseca I, Roque L, Ribeiro C, Soares J (2001) Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Cancer Genet Cytogenet 128:130–136

    Article  CAS  PubMed  Google Scholar 

  189. Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, Soares J (2005) PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. Mod Pathol 18:1048–1055

    Article  CAS  PubMed  Google Scholar 

  190. Fonseca I, Bell A, Wani K, Bell D (2015) Global transcriptome and sequenome analysis of formalin-fixed salivary epithelial-myoepithelial carcinoma specimens. Genes Chromosomes Cancer 54:249–259

    Article  CAS  PubMed  Google Scholar 

  191. El Hallani S, Udager AM, Bell D, Fonseca I, Thompson LDR, Assaad A, Agaimy A, Luvison AM, Miller C, Seethala RR, Chiosea S (2018) Epithelial-myoepithelial carcinoma: frequent morphologic and molecular evidence of preexisting pleomorphic adenoma, common HRAS mutations in PLAG1-intact and HMGA2-intact cases, and occasional TP53, FBXW7, and SMARCB1 alterations in high-grade cases. Am J Surg Pathol 42:18–27

    Article  PubMed  PubMed Central  Google Scholar 

  192. Rito M, Mitani Y, Bell D, Mariano FV, Almalki ST, Pytynia KB, Fonseca I, El-Naggar AK (2018) Frequent and differential mutations of the CYLD gene in basal cell salivary neoplasms: linkage to tumor development and progression. Mod Pathol 31:1064–1072

    Article  CAS  PubMed  Google Scholar 

  193. Agaimy A, Fonseca I, Martins C, Thway K, Barrette R, Harrington KJ, Hartmann A, French CA, Fisher C (2018) NUT carcinoma of the salivary glands: clinicopathologic and molecular analysis of 3 cases and a survey of NUT expression in salivary gland carcinomas. Am J Surg Pathol 42:877–884

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Biomedical Sciences and Medicine, Epigenetics and Human Disease Group, Algarve Biomedical Centre (ABC), Algarve University, Campus de Gambelas, Ala Norte, 8005-139, Faro, Portugal

    Henrik Hellquist

  2. Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany

    Abbas Agaimy

  3. Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany

    Abbas Agaimy

  4. Department of Pathology, Sahlgrenska Center for Cancer Research, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

    Göran Stenman

  5. Section of Pathology, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Alessandro Franchi

  6. Department of Pathology, Hospital Clínic, Barcelona, Spain

    Alfons Nadal

  7. Department of Basic Clinical Practice, School of Medicine, Universitat de Barcelona, Barcelona, Spain

    Alfons Nadal

  8. August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain

    Alfons Nadal

  9. Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic

    Alena Skalova

  10. Department of Pathology and Molecular Genetics, Bioptical Laboratory Ltd, Plzen, Czech Republic

    Alena Skalova

  11. Institute of Biomedicine, Pathology, University of Turku, Turku, Finland

    Ilmo Leivo

  12. Turku University Central Hospital, 20521, Turku, Finland

    Ilmo Leivo

  13. Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    Nina Zidar

  14. Department of Anatomical Pathology, University of Calgary, Calgary, AB, Canada

    Roderick H. W. Simpson

  15. Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Pieter J. Slootweg

  16. Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA

    Juan C. Hernandez-Prera

  17. Coordinator of the International Head and Neck Scientific Group, Padua, Italy

    Alfio Ferlito

Authors
  1. Henrik Hellquist
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  2. Abbas Agaimy
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  3. Göran Stenman
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  4. Alessandro Franchi
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  5. Alfons Nadal
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  6. Alena Skalova
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  7. Ilmo Leivo
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  8. Nina Zidar
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  9. Roderick H. W. Simpson
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  10. Pieter J. Slootweg
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  11. Juan C. Hernandez-Prera
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  12. Alfio Ferlito
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Contributions

Conceptualization and writing the original draft preparation: Hellquist H. Writing-review and editing: Agaimy A, Stenman G, Franchi A, Nadal A, Skalova A, Leivo I, Zidar N, Simpson RHW, Slootweg PJ, Hernandez-Prera JC. Project the manuscript: Ferlito A. All authors have read and agreed to the submitted version of the manuscript.

Corresponding author

Correspondence to Henrik Hellquist.

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This article was written by members and invitees of the International Head and Neck Scientific Group (www.IHNSG.com).

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Hellquist, H., Agaimy, A., Stenman, G. et al. Development of head and neck pathology in Europe. Virchows Arch 480, 951–965 (2022). https://doi.org/10.1007/s00428-022-03275-x

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  • DOI: https://doi.org/10.1007/s00428-022-03275-x

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