Skip to main content
Log in

Mixed germ cell sex cord-stromal tumors, collision or inclusion?

  • Commentary
  • Published:
Virchows Archiv Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Michalova KMJ, Kristiansen G, Steiner P, Grossmann P, Putzova M, Martinek P, Chottova-Dvorakova M, Michal M, Hes O, Michal M (2020) Novel insights into the mixed germ cell-sex cord stromal tumor of the testis: detection of chromosomal aneuploidy and further morphological evidence supporting the neoplastic nature of the germ cell component. Virchows Arch

  2. Talerman A (1979) Gonadal tumours composed of germ cells and sex cord stroma derivatives. Patol Pol 30(2):221–228

    CAS  PubMed  Google Scholar 

  3. Michal M, Vanecek T, Sima R, Mukensnabl P, Hes O, Kazakov DV, Matoska J, Zuntova A, Dvorak V, Talerman A (2006) Mixed germ cell sex cord-stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases. Virchows Arch 448(5):612–622

    Article  Google Scholar 

  4. Michal M, Hes O, Mukensnabl P, Kazakov DV (2007) Mixed germ cell sex cord-stromal tumours of the testis. Virchows Arch 451(6):1095–1096

  5. Ulbright TM, Srigley JR, Reuter VE, Wojno K, Roth LM, Young RH (2000) Sex cord-stromal tumors of the testis with entrapped germ cells: a lesion mimicking unclassified mixed germ cell sex cord-stromal tumors. Am J Surg Pathol 24(4):535–542

    Article  CAS  Google Scholar 

  6. Ulbright TM, Young RH (2007) Reply: mixed germ cell sex cord-stromal tumors of the testis and ovary. Virchows Arch 450(1):131–132

    Article  Google Scholar 

  7. Ulbright TM (2016) Germ cell tumours. In: Moch H (ed) WHO Classification of tumours of the urinary system and male genital organs. IARC Press, Lyon, pp 189–226

  8. Looijenga LH et al (2006) Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Cancer Res 66(1):290–302

    Article  CAS  Google Scholar 

  9. Giannoulatou E, Maher GJ, Ding Z, Gillis AJM, Dorssers LCJ, Hoischen A, Rajpert-de Meyts E, WGS500 Consortium, McVean G, Wilkie AOM, Looijenga LHJ, Goriely A (2017) Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline. PLoS One 12(5):e0178169

    Article  Google Scholar 

  10. Goriely A, Hansen RMS, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GAT, Meyts ERD, Wilkie AOM (2009) Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Nat Genet 41(11):1247–1252

    Article  CAS  Google Scholar 

  11. Oosterhuis JW, Looijenga LHJ (2019) Human germ cell tumours from a developmental perspective. Nat Rev Cancer 19(9):522–537

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. Wolter Oosterhuis.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oosterhuis, J.W. Mixed germ cell sex cord-stromal tumors, collision or inclusion?. Virchows Arch 477, 757–758 (2020). https://doi.org/10.1007/s00428-020-02866-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-020-02866-w

Navigation