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Subsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor—a case report and review of literature

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Abstract

Histiocytic sarcoma (HS) is a rare aggressive hematologic neoplasm that can be associated with low-grade B cell lymphoma. The development of both neoplasms is currently being considered a transdifferentiation mechanism but remains elusive. We report the case of a 65-year-old patient with synchronous development of peritoneal/abdominal HS and grade 1–2 follicular lymphoma (FL). Cytogenetic analysis and targeted next-generation sequencing of both FL and HS tumors identified common genomic alterations such as IGH-BCL2 rearrangement, CREBBP and KMT2D, and aberrations of chromosomes 9q and 19q. However, only the HS tumor had a KRAS mutation while the lymph node involved by FL harbored a TNFAIP3 mutation and both tumors also showed distinct chromosomal alterations. This report strengthens the hypothesis of a common lymphoid progenitor which accumulates genetic alterations leading to two different hematologic malignant diseases with significantly distinct prognoses.

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Fig. 1

Abbreviations

CLL:

Chronic lymphocytic leukemia

CNV:

Copy number variation

FL:

Follicular lymphoma

HS:

Histiocytic sarcoma

LCN:

Langerhans cell neoplasm

LDH:

Lactate dehydrogenase

MCL:

Mantle cell lymphoma;

NMZL:

Nodal marginal zone lymphoma

SMZL:

Splenic marginal zone lymphoma

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Acknowledgments

We thank Pr Pierre Brousset, Dr. Nathalie Van Acker, and Dr. Juliet Raine for reviewing the report, Dr. Marine Borel for contributing to collect sample, Frederic Escudié and David Grand for contributing to the targeted next-generation DNA sequencing, and the Institut Universitaire de France who supported this study.

Funding

This study was funded by the Institut Universitaire du Cancer de Toulouse, the Labex TOUCAN.

Author information

Authors and Affiliations

  1. Departement de Pathologie, Institut Universitaire du Cancer Oncopole, CHU Toulouse, 1 avenue Irène Joliot-Curie, 31059, Toulouse cedex 09, France

    Sarah Péricart, Aurore Siegfried, Camille Laurent & Solène Evrard

  2. Université Paul Sabatier, 118 route de Narbonne 31062, Toulouse cedex 09, France

    Sarah Péricart, Aurore Siegfried, Camille Laurent & Solène Evrard

  3. Département de Chirurgie oncologique, Centre Hospitalier Universitaire - Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France

    Charlotte Waysse

  4. Institut National de la Sante et de la Recherche Médicale, U1037, Centre de Recherches en Cancérologie de Toulouse U1037 and Laboratoire d’Excellence (Labex Toucan), 2 avenue Hubert Curien, 31037, Toulouse cedex 01, France

    Camille Laurent & Solène Evrard

  5. Laboratoire de Cytogénétique, Institut Universitaire du Cancer Oncopole de Toulouse, 1 avenue Irène Joliot-Curie, 31059, Toulouse cedex 09, France

    Stephanie Struski

  6. Laboratoire Hematologie, Institut Universitaire du Cancer Oncopole de Toulouse, 1 avenue Irène Joliot-Curie, 31059, Toulouse cedex 09, France

    Eric Delabesse

Authors
  1. Sarah Péricart
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  2. Charlotte Waysse
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  3. Aurore Siegfried
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  6. Camille Laurent
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  7. Solène Evrard
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Contributions

S Péricart, C Vaysse, C Laurent, and S Evrard collected samples and data. S Péricart, A Siegfried, S Evrard, and C Laurent analyzed the data and wrote the paper. E Delabesse and S Evrard performed and analyzed targeted next-generation DNA sequencing. S Struski performed and analyzed cytogenetic analysis. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sarah Péricart.

Ethics declarations

Ethics approval and consent to participate Tissue samples were collected at the CRB biobank (DC-2008-463 and transfer agreement AC-2008-820) and processed following standard ethical procedures (Helsinki Declaration of 1975) after obtaining written informed consent from the patient. The study was approved by the local ethical committee (Comité de Protection des Personnes Sud-Ouest et Outremer II). For cytogenetics analysis, fresh and thawed samples from the patient were obtained after informed consent and stored at the HIMIP (INSERM-Midi Pyrénées Malignant Blood Diseases collection). According to the French law, the HIMIP collection was declared to the Ministry of Higher Education and Research (DC 2008-307 collection 1) for which a transfer agreement (AC 2008-129) was obtained after approbation by the ethical committee (CPP). Clinical and biological annotations of the samples were declared to the CNIL (Comité National Informatique et Libertés ie Data processing and Liberties National Committee).

Conflict of interest

The authors declare that they have no conflict of interest.

Disclaimer

The opinions, results, and conclusions reported in this paper are those of the authors and are independent of the funding sources. No endorsement by Institute Universitaire de Cancer de Toulouse is intended or should be inferred. Parts of this material are based on data and/or information compiled and provided by the Institute Universitaire de Cancer de Toulouse. However, the analyses, conclusions, opinions, and statements expressed in the material are those of the author(s), and not necessarily those of Institute Universitaire de Cancer de Toulouse.

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Péricart, S., Waysse, C., Siegfried, A. et al. Subsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor—a case report and review of literature. Virchows Arch 476, 609–614 (2020). https://doi.org/10.1007/s00428-019-02691-w

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  • DOI: https://doi.org/10.1007/s00428-019-02691-w

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